Importance of dissolution process on systemic availability of drugs delivered by colon delivery system

Journal of Controlled Release

Volumn 50, Issue 1-3, 1998, Pages 111-122

  Takaya, Tomohiro ^a   Niwa, Kiyoshi ^a   Muraoka, Motoki ^a   Ogita, Ikuo ^a   Nagai, Noriko ^a   Yano, Ryo Ichi ^a   Kimura, Go ^a   Yoshikawa, Yukako ^a   Yoshikawa, Hiroshi ^b   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Fac Pharmaceutical Sci   (Japan)

Author keywords

Colon delivery; Dissolution test; Eudragit S; Pressure controlled colon delivery capsule; Time controlled colon delivery system

Indexed keywords

CARBAMAZEPINE; EUDRAGIT; MESALAZINE; TEGAFUR;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; TABLET;

ANIMALS; BIOLOGICAL AVAILABILITY; CAPSULES; CARBAMAZEPINE; COLON; DOGS; DRUG DELIVERY SYSTEMS; MALE; MESALAMINE; SOLUBILITY; TEGAFUR;

EID: 0032472303     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00123-5     Document Type: Article

References (26)

1. Saffran M., Kumar G.S., Savariar C., Burnham J.C., Williams F., Neckers D.C. A new approach to the oral administration of insulin and other peptide drugs. Science. 233:1986;1081-1084.
2. Ashford M., Fell J.T., Attwood D., Woodhead P.J. An in vitro investigation into the suitability of pH-dependent polymers for colon targeting. Int. J. Pharm. 91:1993;241-245.
3. Peters R., Kinget R. Film-forming polymers for colonic drug delivery: I. Synthesis and physical and chemical properties of methyl derivatives of Eudragit S. Int. J. Pharm. 94:1993;125-134.
4. Watts P.T., Wilson C.G., Davies M.C., Melia C.D. Radiolabelling of polymer microspheres for scintigraphic investigations by neutron activation. 4. A pharmacoscintigraphic study of colon-targeted Eudragit RS-sulphapyridine microspheres in human volunteers. Int. J. Pharm. 102:1994;101-108.
5. Wilding I.R., Davis S.S., Pozzi F., Furlani P., Gazzaniga A. Enteric coated timed release systems for colonic targeting. Int. J. Pharm. 111:1994;99-102.
6. Kraeling M.E.K., Ritschel W.A. Development of colonic release capsule dosage form and the absorption of insulin. Meth. Find. Clin. Pharmacol. 14:1992;199-209.
7. A. Rashid, Dispensing Device, British Patent Application 2230441 A, 15 Feb. 1990.
8. Brøndsted H., Kopeček J. Hydrogels for site-specific drug delivery to the colon: In vitro and in vivo degradation. Pharm. Res. 9:1992;1540-1545.
9. Leopold C.S., Friend D.R. In vivo pharmacokinetic study for the assessment of poly (L-aspartic acid) as a drug carrier for colon-specific drug delivery. J. Pharmacokin. Biopharm. 23:1995;397-406.
10. Ashford M., Fell J., Attwood D., Sharma H., Woodhead P. Studies on pectin formulations for colonic drug delivery. J. Control. Release. 30:1994;225-232.
11. Hovgaard L., Brøndsted H. Dextran hydrogels for colon-specific drug delivery. J. Control. Release. 36:1995;159-166.
12. Milojevic S., Newton J.M., Cummings J.H., Gibson G.R., Botham R.L., Ring S.G., Stockham M., Allwood M.C. Amylose as a coating for drug delivery to the colon: Preparation and in vitro evaluation using 5-aminosalicylic acid pellets. J. Control. Release. 38:1996;75-84.
13. Takaya T., Ikeda C., Imagawa N., Niwa K., Takada K. Development of a colon delivery capsule and the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in beagle dogs. J. Pharm. Pharmacol. 47:1995;474-478.
14. Niwa K., Takaya T., Morimoto T., Takada K. Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs. J. Drug Targeting. 3:1995;83-89.
15. Takaya T., Sawada K., Suzuki H., Funaoka A., Matsuda K., Takada K. Application of a colon delivery capsule to 5-aminosalicylic acid and evaluation of the pharmacokinetic profile after oral administration to beagle dogs. J. Drug Targeting. 4:1997;271-276.
16. Matsuda K., Takaya T., Shimoji F., Muraoka M., Yoshikawa Y., Takada K. Effect of food intake on the delivery of fluorescein as a model drug in colon delivery capsule after oral administration to beagle dogs. J. Drug Targeting. 4:1996;59-67.
17. Rao S., Ritschel W.A. Colonic drug delivery of small peptides. S.T.P. Pharma Sciences. 5:1995;19-29.
18. Olsson B., Wager Z.G., Mansion P., Ragnarsson G. A gamma scintigraphic study of the absorption of morphine from controlled-release tablets. Int. J. Pharm. 119:1995;223-229.
19. Caprilli R., Andreoli A., Capurso L., Corrao G., D'albasio G., Gioieni A., Assuero Lanfranchi G., Paladini I., Pallone F., Ponti V., Rigo G.P., Rossini F.P., Sturniolo G.C., Tonelli F., Valpiani D. Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of Crohn's disease. Aliment. Pharamacol. Ther. 8:1994;35-43.
20. Pellicclari R., Garzon-Aburbeh A., Natalini B., Marinozzi M., Clerici C., Gentili G., Moreili A. Brush-border-enzyme-mediated intestine-specific drug delivery. Amino acid prodrugs of 5-aminosalicylic acid. J. Med. Chem. 36:1993;4201-4207.
21. Peppercorn M.A., Goldman P. Distribution studies of salicylazosulfapyridine and its metabolises. Gastroenterology. 64:1973;240-245.
22. Wadworth A.N., Fitton A. Olsalazine. A review of its pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs. 41:1991;647-664.
23. S.S. Davis, Small intestinal transit, in: J.G. Hardy, S.S. Davis and C.G. Willson (Eds.), Drug delivery to the gastrointestinal tract, Ellis Horwood Limited, Chichester, England, 1989, p. 49.
24. Dressman J.B. Comparison of canine and human gastrointestinal physiology. Pharm. Res. 3:1986;123-131.
25. Riad L.E., Sawchuk R.J. Absorptive clearance of carbamazepine and selected metabolises in rabbit intestine. Pharm. Res. 8:1991;1050-1055.
26. 12N-labelled drug to healthy volunteers. Br. J. Clin. Pharmacol. 32:1991;573-579.