Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity

Organic and Biomolecular Chemistry

Volumn 1, Issue 18, 2003, Pages 3139-3141

  Tsuji, Eriko ^a   Ando, Kumiko ^a   Kunitomo, Jun Ichi ^a   Yamashita, Masayuki ^b   Ohta, Shunsaku ^b   Kohno, Shigekatsu ^b   Ohishi, Yoshitaka ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; AROMATIC COMPOUNDS; CARBOXYLIC ACIDS; CHEMICAL MODIFICATION; DERIVATIVES; ISOMERS; MOLECULAR STRUCTURE; PRECIPITATION (CHEMICAL); SOLUTIONS; THERMAL EFFECTS;

CHEMICAL REAGENTS;

BIOCHEMISTRY;

BENZOFURAN; BENZOFURAN DERIVATIVE; CYSTEINYL LEUKOTRIENE RECEPTOR 2; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEMBRANE PROTEIN;

ARTICLE; ASTHMA; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METHODOLOGY; ORGANIC CHEMISTRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ASTHMA; BENZOFURANS; CHEMISTRY, ORGANIC; CRYSTALLOGRAPHY, X-RAY; HUMANS; LEUKOTRIENE ANTAGONISTS; MEMBRANE PROTEINS; MODELS, CHEMICAL; MODELS, MOLECULAR; RECEPTORS, LEUKOTRIENE;

EID: 0141860921     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b307468d     Document Type: Article

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12. 3,5-Diamino-2-ethylbenzo[b]furan was obtained by catalytic hydrogenation of 2-ethyl-3,5-dinitrobenzo[b]furan over Pd/C in EtOH.
13. w = 0.170). CCDC reference number 214287. See http://www.rsc.org/suppdata/ob/b3/b307468d/ for crystallographic data in CIF or other electronic format.
14. The assays were achieved according to the procedure reported by Nothacker et al. (ref. 1a).
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