Identification of adenovirus (Ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative Ad (Addl1520) for treatment of liver tumors

Journal of Virology

Volumn 77, Issue 19, 2003, Pages 10366-10375

  Hong, Saw See ^a   Habib, Nagy A ^b   Franqueville, Laure ^a   Jensen, Steen ^b   Boulanger, Pierre A ^a  

^a UNIVERSITÉ DE LYON   (France)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INTEGRIN; NEUTRALIZING ANTIBODY; ONYX 015; PEPTIDE DERIVATIVE; PROTEIN HEXON; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; ADENOVIRUS DL1520; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY ISOLATION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIOPHAGE; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; INTERNALIZATION; LIVER CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; VIRUS MUTANT;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; CAPSID; CAPSID PROTEINS; EPITOPE MAPPING; GENE THERAPY; HUMANS; LIVER NEOPLASMS; NEUTRALIZATION TESTS; SPODOPTERA;

EID: 0141856338     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.19.10366-10375.2003     Document Type: Article

References (36)

1. Barker, D. D., and A. J. Berk. 1987. Adenovirus proteins from both E1B reading frames are required for the transformation of rodent cells by viral infection and DNA transfection. Virology 156:107-121.
2. Bischoff, J. R., D. H. Kirn, A. Williams, C. Heise, S. Horn, M. Muna, L. Ng, J. A. Nye, A. Sampson-Johannes, A. Fattaey, and F. McCormick. 1996. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274:373-376.
3. Boulanger, P., and F. Puvion. 1973. Large-scale preparation of soluble adenovirus hexon, penton and fiber antigens in highly purified form. Eur. J. Biochem. 39:37-42.
4. Chen, Y., D.-C. Yu, D. Charlton, and D. R. Henderson. 2000. Pre-existent adenovirus antibody inhibits systemic toxicity and antitumor activity of CN706 in the nude mouse LNCaP xenograft model: implications and proposals for human therapy. Hum. Gene Ther. 11:1553-1567.
5. Crawford-Miksza, L., and D. P. Schnurr. 1996. Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues. J. Virol. 70:1836-1844.
6. Fender, P., A. H. Kidd, R. Brebant, M. Oberg, and J. Chroboczek. 1995. Antigenic sites on the receptor-binding domain of human adenovirus type 2 fiber. Virology 214:110-117.
7. Gahéry-Ségard, H., F. Farace, D. Godfrin, J. Gaston, R. Lengagne, T. Tursz, P. Boulauger, and J.-G. Guillet. 1998. Immune response to recombinant capsid proteins of adenovirus in humans: anti-fiber and anti-penton base antibodies have a synergistic effect on neutralizing activity. J. Virol. 72:2388-2397.
8. Ganly, I., D. Kirn, S. G. Eckhardt, G. I. Rodriguez, D. S. Soutar, R. Otto, A. G. Robertson, O. Park, M. L. Gulley, C. Heise, D. Von Hoff, and S. B. Kaye. 2000. A Phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin. Cancer Res. 6:798-806.
9. Habib, N., H. Salama, A. Abd El Latif Abu Median, I. Isac Anis, R. A. Abd Al Aziz, C. Sarraf, R. Mitry, R. Havlik, P. Seth, J. Hartwigsen, R. Bhushan, J. Nicholls, and S. Jensen. 2002. Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma. Cancer Gene Ther. 9:254-259.
10. Habib, N. A., C. E. Sarraf, R. R. Mitry, R. Havlik, J. Nicholls, M. Kell, C. C. Vernon, D. Gueret-Wardle, R. El-Masry, H. Salama, R. Ahmed, N. Michail, E. Edward, and S. L. Jensen. 2001. E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors. Hum. Gene Ther. 12:219-226.
11. Hong, S. S., M. Bardy, M. Monteil, B. Gay, C. Denesvre, J. Tournier, G. Martin, M. Eloit, and P. Boulanger. 2000. Immunoreactive domains and integrin-binding motifs in adenovirus penton base capsomer. Viral Immunol. 13:353-371.
12. Hong, S. S., and P. Boulanger. 1995. Protein ligands of the human adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of wild-type and mutant penton capsomers. EMBO J. 14:4714-4727.
13. Hong, S. S., L. Karayan, J. Tournier, D. T. Curiel, and P. Boulanger. 1997. Adenovirus type 5 fiber knob binds MHC class I a2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J. 16:2294-2306.
14. Karayan, L., S. S. Hong, B. Gay, J. Tournier, A. Dupuy d'Angeac, and P. Boulanger. 1997. Structural and functional determinants in adenovirus type 2 penton base recombinant protein. J. Virol. 71:8678-8689.
15. Kirn, D. 2001. Clinical research results with dl1520 (ONYX-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? Gene Ther. 8:89-98.
16. Kirn, D., R. L. Maurtuza, and J. Zwiebel. 2001. Replication-selective virotherapy for cancer: biological principles, risk management and future directions. Nat. Med. 7:781-787.
17. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
18. 1 is an adenovirus coreceptor. J. Virol. 75:5405-5409.
19. Liebermann, H., K. Lotz, R. Mentel, U. Bauer, and W. Seidel. 2001. Mapping of linear epitopes on fibre knob of human adenovirus serotype 5. Virus Res. 73:145-151.
20. Liebermann, H., K. Lotz, and W. Seidel. 2002. Mapping of epitopes on the fiber knobs of human adenovirus serotypes 8 and 15. Intervirology 45:59-66.
21. Mei, Y. F., and G. Wadell. 1996. Epitopes and hemagglutination binding domain on subgenus B:2 adenovirus fibers. J. Virol. 70:3688-3697.
22. Mittal, S. K., M. R. McDermott, D. C. Johnson, L. Prevec, and F. L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res. 28:67-90.
23. Molinier-Frenkel, V., R. Lengagne, F. Gaden, S. S. Hong, J. Choppin, H. Gahery-Ségard, P. Boulanger, and J.-G. Guillet. 2002. Adenovirus hexon protein is a potent adjuvant for activation of a cellular immune response. J. Virol. 76:127-135.
24. Nakano, M. Y., K. Boucke, M. Souomalainan, R. P. Stidwill, and U. F. Greber. 2000. The first step of adenovirus type 2 disassembly occurs at the cell surface, independently of endocytosis and escape to the cytosol. J. Virol. 74:7085-7095.
25. Rahman, A., V. Tsai, A. Goudreau, J. Y. Shinoda, S. F. Wen, M. Ramachandra, R. Ralson, D. Maneval, D. LaFace, and P. Shabram. 2001. Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy. Mol. Ther. 3:768-778.
26. Rux, J. J., and R. M. Burnett. 2000. Type-specific epitope locations revealed by x-ray crystallographic study of adenovirus type 5 hexon. Mol. Ther. 1:18-30.
27. Schoehn, G., P. Fender, J. Chroboczek, and E. A. Hewat. 1996. Adenovirus 3 penton dodecahedron exhibits structural changes of the base on fibre binding. EMBO J. 15:6841-6846.
28. Schulick, A. H., G. Vassalli, P. F. Dunn, G. Dong, J. J. Rade, C. Zamarron, and D. A. Dichek. 1977. Established immunity precludes adenovirus-mediated gene transfer rat carotid arteries: potential for immunosuppression and vector engineering to overcome barriers of immunity. J. Clin. Investig. 99:209-219.
29. Stallwood, Y., K. D. Fisher, P. H. Gallimore, and V. Mautner. 2000. Neutralization of adenovirus infectivity by ascitic fluid from ovarian cancer patients. Gene Ther. 7:637-643.
30. Stewart, P. L., C. Y. Chiu, S. Huang, T. Muir, Y. Zhao, B. Chait, P. Mathias, and G. R. Nemerow. 1997. Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization. EMBO J. 16:1189-1198.
31. Sung, M. W., H.-C. Yeh, S. N. Thung, M. E. Schwartz, J. P. Mandeli, S.-H. Chen, and S. L Woo. 2001. Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a Phase I Clinical Trial. Mol. Ther. 4:182-190.
32. Toogood, C. I., J. Crompton, and R. T. Hay. 1992. Antipeptide antisera define neutralizing epitopes on the adenovirus hexon. J. Gen. Virol. 73:1429-1435.
33. van Raaij, J. M., A. Mitraki, G. Lavigne, and S. Cusack. 1999. A triple beta-spiral in the adenovirus fiber shaft reveals a new structural motif for a fibrous protein. Nature 401:935-938.
34. Vincent, T., B.-G. Harvey, S. M. Hogan, C. J. Bailey, R. G. Crystal, and P. L. Leopold. 2001. Rapid assessment of adenovirus serum neutralizing antibody titer based on quantitative, morphometric evaluation of capsid binding and intracellular trafficking: population analysis of adenovirus capsid association with cells is predictive of adenovirus infectivity. J. Virol. 75:1516-1521.
35. 5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
36. Wohlfart, C. 1988. Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms. J. Virol. 62:2321-2328.