Significant issues raised by meta-analysis of cancer mortability and dioxin exposure

Environmental Health Perspectives

Volumn 111, Issue 12, 2003, Pages 1443-1447

  Starr, Thomas B ^a  

^a TBS Associates   (United States)

Author keywords

Dioxin; Direct acting carcinogen; Dose response assessment; Meta analysis; Occupational cohort; Promoter

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CARCINOGEN; DIOXIN;

ADULT; ARTICLE; CANCER MORTALITY; CARCINOGENICITY; CONCENTRATION (PARAMETERS); DIETARY INTAKE; DOSE RESPONSE; FOOD SAFETY; GOVERNMENT; HALF LIFE TIME; HUMAN; LONG TERM EXPOSURE; MALE; META ANALYSIS; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; UNITED STATES; WORK ENVIRONMENT; WORKPLACE;

EID: 0141852142     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6219     Document Type: Article

References (28)

1. Adami H-O, Cole P, Mandel J, Pastides H, Starr TB, Trichopoulos D. 2000, Dioxin and Cancer. Menlo Park, CA:Exponent.
2. Aylward LL, Hays SM, Karch NJ, Paustenbach DJ, 1996. Relative susceptibility of animals and humans to the cancer hazard posed by 2,3,7,8-tetrachloradibenzo-p-dioxin using internal measures of dose. Environ Sci Technol 30:3534-3543.
3. Berenblum I, Shubik P. 1947. A new, quantitative approach to the study of the stages of chemical carcinogenesis in the mouse's skin. Br J Cancer 1:383-391.
4. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Herrmann R. 1984. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5(4):453-458.
5. Collins JJ, Acquavella JF, Friedlander BR. 1992. Reconciling old and new findings on dioxin. Epidemiology 3(1):65-69.
6. Crump KS, Canady R, Kogevinas M. 2003. Meta-analysis of dioxin cancer dose-response for three occupational cohorts. Environ Health Perspect 111:681-687; doi:10.1289/ehp.5831 [Online 30 October 2002].
7. Emmelot P, Scherer E. 1980. The first relevant cell stage in rat liver carcinogenesis: a quantitative approach. Biochim Biophys Acta 605:247-304.
8. Farber E. 1982. Sequential events in chemical carcinogenesis. In: Cancer: A Comprehensive Treatise, Vol 1 (Becker FF, ed). 2nd ed. New York:Plenum, 485-506.
9. Fingerhut M, Halperin WE, Marlow DA, Piacitelli LA, Honchar PA, Sweeney MH, et al. 1991. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med 324:212-218.
10. Flesch-Janys D, Becher H, Gurn P, Jung D, Konietzko J, Manz A, et al. 1996. Elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans (OCDD/F) in occupationally exposed persons. J Toxicol Environ Health 47:363-378.
11. Flesch-Janys D, Steindorf K, Gurn P, Becher H. 1998. Estimation of the cumulated exposure to polychlorinated dibenzo-p-dioxins/furans and standardized mortality ratio analysis of cancer mortality by dose in an occupationally exposed cohort. Environ Health Perspect 106(suppl 2):655-662.
12. McGregor DB, Partensky C, Wilbourn J, Rice JM. 1998. An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ Health Perspect 106(suppl 2):755-760.
13. Michalek M, Pirkle J, Caudill S, Tripathi RC, Patterson DG Jr, Needham LL. 1996. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J Toxicol Environ Health 47(3):209-220.
14. Michalek M, Tripathi RC. 1999. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 15-year follow-up. J Toxicol Environ Health 57:369-378.
15. Ott MG, Messerer P, Zober A. 1993. Assessment of past occupation exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin using blood lipid analyses. Int Arch Occup Environ Health 65:1-8.
16. Ott MG, Zober A. 1996. Cause specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident. Occup Environ Med 53:606-612.
17. Paustenbach DJ. 2002. The U.S. EPA Science Advisory Board Evaluation (2001) of the EPA dioxin reassessment. Regul Toxicol Pharmacol 36:211-219.
18. Piacitelli L, Marlow D, Fingerhut M, Steenland K, Sweeney MH. 2000. A restrospective job exposure matrix estimating exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Am J Ind Med 38:28-39.
19. Starr TB. 2001. Significant shortcomings of the U.S. Environmental Protection Agency's latest draft risk characterization for dioxin-like compounds. Toxicol Sci 64:7-13.
20. Starr TB, Greenlee WF, Neal RA, Poland A, Sutter TR. 1999. The trouble with TEFs [Letter]. Environ Health Perspect 107:A492-A493.
21. Starr TB, Zacharewski T, Sutter T, Safe S, Greenlee W, Connolly R. 1997. Concerns with the use of a toxic equivalency factor (TEF) approach for risk assessment of "dioxin-like" compounds. Organohalogen Compounds 34:91-94.
22. Steenland K, Deddens J, Piacitelli. 2001. Risk assessment for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on an epidemiologic study. Am J Epidemiol 154:451-458.
23. Steenland K, Piacitelli L, Deddens J, Fingerhut M, Chang LI. 1999. Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Natl Cancer Inst 91:779-786.
24. U.S. EPA. 2000. Draft Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds. Part III: Integrated Summary and Risk Characterization for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds. EPA/600/P-00/001 Bg. Washington DC:U.S. Environmental Protection Agency. Available: http://cfpub.epa.gov/ncea/cfm/part3.cfm?ActType=default [accessed 25 June 2003].
25. U.S. EPA. 2001. Dioxin Reassessment - An SAB Review of the Office of Research and Development's Reassessment of Dioxin. EPA-SAB-EC-01-006. Washington DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/sab/pdf/ec01006.pdf [accessed 25 June 2003].
26. Van den Berg M, Birnbaum L, Bosveld ATC, Brunström B, Cook P, Feeley M, et al. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775-792.
27. Whittemore A, Keller JB. 1978. Quantitative theories of carcinogenesis. SIAM Rev 20:1-30.
28. Xu YH, Maronpot R, Pitot HC. 1990. Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis. Carcinogenesis 11(2):267-272.