Estimation of the cumulated exposure to polychlorinated dibenzo-p-dioxins/furans and standardized mortality ratio analysis of cancer mortality by dose in an occupationally exposed cohort

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 2, 1998, Pages 655-662

  Flesch Janys, Dieter ^a,d   Steindorf, Karen ^b   Gurn, Petra ^c   Becher, Heiko ^b  

^a Center for Chemical Workers' Health   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF BREMEN   (Germany)

^d Department of Environment and Health   (Germany)

Author keywords

Area under the curve; Cancer mortality; Dose response; Exposure quantification; Occupational exposure; PCDD F; Polychlorinated dibenzo p dioxins furans; Risk assessment

Indexed keywords

POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN;

CANCER MORTALITY; CANCER RISK; COHORT ANALYSIS; CONFERENCE PAPER; FEMALE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0031803559     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106655     Document Type: Conference Paper

References (29)

1. Lucier G, Clark G, Hiermath C, Tritscher A, Sewdl C, Huff J. Carcinogenicity of TCDD in laboratory animals-implications for risk assessment. Toxicol Ind Health 9:631-668 (1993).
2. Zober A, Messerer P, Huber P. Thirty-four year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident. Int Arch Occ Environ Health 62:139-157 (1990).
3. Fingerhut MA, Halperin WE, Marlow DA, Piacitelli LA, Honchar PA, Sweeney MH, Greife A, Dill P, Steenland K, Suruda A. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. New Engl J Med 199:212-218 (1991).
4. Manz A, Berger J, Dwyer JH, Flesch-Janys D, Nagel S, Waltsgott H. Cancer mortality among workers in a chemical plant contaminated with dioxin. Lancet 338:959-964 (1991).
5. Ott M, Zober A. Cause specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident. Occ Environ Med 53:606-612 (1996).
6. Kogevinas M, Becher H, Benn T, Bertazzi PA, Boffetta P, Bas Bueno-de-Mesquita H, Coggon D, Colin D, Flesch-Janys D et al. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols and dioxins. An international cohort study. Am J Epidemiol 145:1061-1075 (1997).
7. Becher H, Flesch-Janys D, Kauppinen T, Kogevinas M, Steindorf K, Manz A, Wahrendorf J. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control 7:312-321 (1996).
8. Bertazzi PA, Zocchetti C, Pesatori AC, Guercilena S, Sanarico M, Radice L. Ten-year mortality study of the population involved in the Seveso incident in 1976. Am J Epidemiol 129:1187-1200 (1989).
9. Bertazzi PA, Pesatori AC, Consonni D, Tironi A, Landi MT, Zocchetti C. Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiology 4:398-406 (1993).
10. Bertazzi PA, Pesatori AC, Landi MT, Zocchetti C, Guercilena S, Consonni D, Tironi A. Cancer mortality, 1976-1991, in the population exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen Compounds 30:294-297 (1996).
11. U.S. EPA. Health Assessment Document for Polychlorinated Dibenzo-p-Dioxins. EPA/600/8-84/014 F. Washington:U.S. Governmental Protection Agency, 1985.
12. World Health Organization. Unpublished data. 13. Health Council of the Netherlands: Committee on the Risk Evaluation of Substances/Dioxins. Polychlorinated Dibenzo-p-dioxins, Dibenzofurans and Dioxin-like Polychlorinated Biphenyls. Publ No 1996/10E. Rijswijk, The Netherlands:Health Council of the Netherlands, 1996.
13. Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, Dittenber DA, Kalins RP, Frauson LE, Park CN, Barnard SD et al. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachloro-dibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46:279-303 (1978).
14. Flesch-Janys D, Berger J, Manz A, Nagel S, Waltsgorr H, Dwyer JH. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide producing plant in Hamburg, FRG. Am J Epidemiol 142(11): 1165-1175 (1995). Erratum: Am J Epidemiol 144(7):716 (1996).
15. Paustenbach D, Karch N, Golden R, Kerger B, Leung HW. The relative susceptibility of animals and humans to carcinogenic hazard posed by exposure to 2,3,7,8-TCDD: an analysis of standard and alternative dosimetric measures. Organohalogen Compounds 26:31-34 (1995).
16. Becher H, Steindorf K, Flesch-Janys D. Quantitative cancer risk assessment for dioxins using an occupational cohort. Environ Health Perspect 106(Suppl 2):663-670 (1998).
17. Stephens RD, Rappe C, Hayward DG, Nygren M, Startin J, Esboll A, Cari, J, Yrjänhheikki E. World Health Organization international intercalibration study on dioxins and furans in human milk and blood. Anal Chem 64:3109-3117 (1992).
18. Beck H, Eckart K, Mathar W, Wittkowski R. Levels of PCDDs and PCDFs in adipose tissue of occupationally exposed workers. Chemosphere 18:507-516 (1989).
19. Ahlborg UG, Brower A, Fingerhut MA, Jacobson JL, Jacobson SW, Kennedv SW, Kettrup AAF, Koeman JH, Poiger H, Rappe C et al. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and byphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. Euro J Pharmacol 228:179-200, 1992.
20. Flesch-Janys D, Berger J, Konietzko J, Manz A, Nagel S, Wahrendorf J. Quantification of exposure to dioxins and furans in a cohort of a herbicide producing plant in Hamburg, FRG. Chemosphere 25(7-10):1021-1028 (1992).
21. Päpke O, Ball M, Lis ZA, Scheunert K. PCDD/PCDF in whole blood samples of unexposed persons. Chemosphere 19:941-948 (1989).
22. Päpke O, Ball M, Lis A. PCDD/PCDF in humans - an update of background data. Dioxin '93. Organohalogen Compounds 13:81-84 (1993).
23. Päpke O, Ball M, Lis A. PCDD/PCDF in humans, a 1993 update of background data. Chemosphere 29:2355-2360 (1994).
24. Breslow NE, Day NE, eds. Statistical Methods in Cancer Research. Volume II: The Design and Analysis of Cohort Studies, IARC Sci Publ No 82. Lyon:International Agency for Research on Cancer, 1987; 1-406.
25. Flesch-Janys D, Becher H, Gurn P, Jung D, Konietzko J, Manz A, Päpke O. Elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in occupationally exposed persons. J Toxicol Environ Health 47:363-378. (1996).
26. Michalek JE, Pirkle JL, Caudill SP, Tripathi RC, Patterson DG, Neediam LL Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J Toxicol Environ Health 47:209-220 (1996).
27. Hooiveld M, Heederik D, Bas Bueno-de-Mesquita H. Preliminary results of the second follow-up of a Dutch cohort of workers occupationally exposed to phenoxy herbicides, chlorophenols and contaminants. Organohalogen Compounds 30:185-189(1996).
28. Jung D, Becher H, Edler L, Flesch-Janys D, Gurn P, Konietzko J, Manz A, Päpke O. Elimination of p-hexachlorocyclohexane in occupationally exposed persons. J Toxicol Environ Health 51:23-34 (1997).
29. Belseley DA, Welsch RE. Regression Diagnostics. New York:John Wiley & Sons, 1980.