The activator-binding site of Onchocerca volvulus s-adenosylmethionine decarboxylase, a potential drug target

Biological Chemistry

Volumn 384, Issue 8, 2003, Pages 1195-1201

  Ndjonka, Dieudonne ^a   Zou, Yu ^b   Bi, Xiangdong ^b   Woster, Patrick ^b   Walter, Rolf D ^a   Lüersen, Kai ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Enzyme inhibition; Nematodes; Onchocerca volvulus; Polyamine analogues; S Adenosylmethionine decarboxylase

Indexed keywords

1,15 DIAMINO 4,12 DIAZAPENTADECANE; 1,3 PROPANEDIAMINE; 1,6 HEXANEDIAMINE; 1,7 DIAMINOHEPTANE; 1,8 OCTANEDIAMINE; ADENOSYLMETHIONINE DECARBOXYLASE; AMINO ACID; BW 1; CADAVERINE; DIAMINE; ENZYME INHIBITOR; ETHYLENEDIAMINE; N,N' BIS(3 BENZYLAMINOPROPYL) 1,7 HEPTANEDIAMINE; N1 ACETYLSPERMIDINE; N8 ACETYLSPERMIDINE; ORNITHINE; PMW 2000 11 13 1; PMW 2000 11 13 5; POLYAMINE; POLYAMINE DERIVATIVE; PUTRESCINE; PUTRESCINE DERIVATIVE; RHW 17 69 75; SPERMIDINE; SPERMINE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; YZ 33 003; YZ 33 046; YZ 33 050C;

ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; ONCHOCERCA VOLVULUS; PRIORITY JOURNAL;

ADENOSYLMETHIONINE DECARBOXYLASE; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATORS; ENZYME INHIBITORS; HUMANS; ONCHOCERCA VOLVULUS; POLYAMINES; PUTRESCINE;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; EUKARYOTA; NEMATODA; ONCHOCERCA; ONCHOCERCA VOLVULUS;

EID: 0141850264     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.132     Document Type: Article

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