A structural analysis of the interaction between ncd tail and tubulin protofilaments

Journal of Molecular Biology

Volumn 333, Issue 3, 2003, Pages 541-552

  Wendt, Thomas ^a   Karabay, Arzu ^b,d   Krebs, Angelika ^a   Gross, Heinz ^c   Walker, Richard ^b   Hoenger, Andreas ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c ETH ZURICH   (Switzerland)

^d ISTANBUL TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Kinesin; Microtubules; ncd tail domain; Non claret disjunctional (ncd)

Indexed keywords

KINESIN; MICROTUBULE ASSOCIATED PROTEIN; TAU PROTEIN; TUBULIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CRYOELECTRON MICROSCOPY; MICROTUBULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

STAPHYLOCOCCUS PHAGE 187;

EID: 0141750616     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.08.051     Document Type: Article

References (32)

1. Goldstein L.S., Philp A.V. The road less traveled: emerging principles of kinesin motor utilization. Annu. Rev. Cell Dev. Biol. 15:1999;141-183.
2. Hirokawa N. Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science. 279:1998;519-526.
3. Vale R.D., Milligan R.A. The way things move: looking under the hood of molecular motor proteins. Science. 288:2000;88-95.
4. Mandelkow E., Hoenger A. Structures of kinesin and kinesin-microtubule interactions. Curr. Opin. Cell Biol. 11:1999;34-44.
5. Vale R.D. The molecular motor toolbox for intracellular transport. Cell. 112:2003;467-480.
6. McDonald H.B., Stewart R.J., Goldstein L.S. The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell. 63:1990;1159-1165.
7. Chandra R., Salmon E.D., Erickson H.P., Lockhart A., Endow S.A. Structural and functional domains of the Drosophila ncd microtubule motor protein. J. Biol. Chem. 268:1993;9005-9013.
8. Walker R.A., Salmon E.D., Endow S.A. The Drosophila claret segregation protein is a minus-end directed motor molecule. Nature. 347:1990;780-782.
9. Hoenger A., Milligan R.A. Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry. J. Mol. Biol. 265:1997;553-564.
10. Hirose K., Lockhart A., Cross R.A., Amos L.A. Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules. Proc. Natl Acad. Sci. USA. 93:1996;9539-9544.
11. Foster K.A., Gilbert S.P. Kinetic studies of dimeric Ncd: evidence that Ncd is not processive. Biochemistry. 39:2000;1784-1791.
12. Wendt T.G., Volkmann N., Skiniotis G., Goldie K.N., Muller J., Mandelkow E., Hoenger A. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J. 21:2002;5969-5978.
13. Karabay A., Walker R.A. Identification of microtubule binding sites in the Ncd tail domain. Biochemistry. 38:1999;1838-1849.
14. Karabay A., Walker R.A. The Ncd tail domain promotes microtubule assembly and stability. Biochem. Biophys. Res. Commun. 258:1999;39-43.
15. Beuron F., Hoenger A. Structural analysis of the microtubule-kinesin complex by cryo-electron microscopy. Methods Mol. Biol. 164:2001;235-254.
16. Karabay A., Walker R.A. Identification of Ncd tail domain-binding sites on the tubulin dimer. Biochem. Biophys. Res. Commun. 305:2003;523-528.
17. Crepeau R.H., McEwen B., Dykes G., Edelstein S.J. Structural studies on porcine brain tubulin in extended sheets. J. Mol. Biol. 116:1977;301-315.
18. Hoenger A., Sablin E.P., Vale R.D., Fletterick R.J., Milligan R.A. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 376:1995;271-274.
19. Hoenger A., Doerhoefer M., Woehlke G., Tittmann P., Gross H., Song Y.H., Mandelkow E. Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs. Biol. Chem. 381:2000;1001-1011.
20. Mandelkow E.M., Mandelkow E. Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly. J. Mol. Biol. 181:1985;123-135.
21. Sablin E.P., Kull F.J., Cooke R., Vale R.D., Fletterick R.J. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 380:1996;555-559.
22. Sosa H., Dias D.P., Hoenger A., Whittaker M., Wilson-Kubalek E., Sablin E., et al. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 90:1997;217-224.
23. Hoenger A., Thormahlen M., Diaz-Avalos R., Doerhoefer M., Goldie K.N., Muller J., Mandelkow E. A new look at the microtubule binding patterns of dimeric kinesins. J. Mol. Biol. 297:2000;1087-1103.
24. Kar S., Fan J., Smith M.J., Goedert M., Amos L.A. Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. EMBO J. 22:2003;70-77.
25. Al-Bassam J., Ozer R.S., Safer D., Halpain S., Milligan R.A. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J. Cell Biol. 157:2002;1187-1196.
26. Sablin E.P., Case R.B., Dai S.C., Hart C.L., Ruby A., Vale R.D., Fletterick R.J. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 395:1998;813-816.
27. Dubochet J., Adrian M., Chang J.J., Homo J.C., Lepault J., McDowall A.W., Schultz P. Cryo-electron microscopy of vitrified specimens. Quart. Rev. Biophys. 21:1988;129-228.
28. Gross H., Krusche K., Tittmann P. Recent Progress in High-resolution Shadowing for Biological Transmission Electron Microscopy. Proceedings XII-th International Congress on Electron Microscopy, Seattle. 1990;San Francisco Press, San Francisco, CA. pp. 510-511.
29. Whittaker M., Carragher B.O., Milligan R.A. PHOELIX: a package for semi-automated helical reconstruction. Ultramicroscopy. 58:1995;245-259.
30. Schroeter J.P., Bretaudiere J.P. SUPRIM: easily modified image processing software. J. Struct. Biol. 116:1996;131-137.
31. Milligan R.A., Flicker P.F. Structural relationships of actin, myosin and tropomyosin reveals by cryo-electron microscopy. J. Cell Biol. 105:1987;29-39.
32. Esnouf R.M. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. Model. 15:1997;132-134.