Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: Results of retreatments in a phase 1 and 2 study

Archives of Ophthalmology

Volumn 117, Issue 9, 1999, Pages 1177-1187

  Schmidt Erfurth, Ursula ^a   Miller, Joan W ^b   Sickenberg, Michel ^c   Laqua, Horst ^a   Barbazetto, Irene ^a   Gragoudas, Evangelos S ^b   Zografos, Leonidas ^c   Piguet, Bertrand ^c   Pournaras, Constantin J ^d   Donati, Guy ^d   Lane, Anne Marie ^b   Birngruber, Reginald ^a   Van Den Berg, Hubert ^e   Strong, H Andrew ^f   Manjuris, Ulrike ^f   Gray, Todd ^g   Fsadni, Mario ^h   Bressler, Neil M ⁱ  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HÔPITAL OPHTALMIQUE JULES GONIN   (Switzerland)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e EPFL   (Switzerland)

^f QLT PhotoTherapeutics Inc   (Canada)

^g CIBA Vision Corporation   (United States)

^h CIBA Vision AG   (Switzerland)

ⁱ JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPORPHYRIN DERIVATIVE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; MALE; MULTICENTER STUDY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 0032871253     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.117.9.1177     Document Type: Article

References (25)

1. Klein R, Klein BEK, Linton KLP. Prevalence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1992;99:933-943.
2. Ferris F III, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640-1642.
3. Hyman LG, Lilienfeld AM, Ferris FL III, Fine SL. Senile macular degeneration: a case-control study. Am J Epidemiol. 1983;118:213-227.
4. Macular Photocoagulation Study Group. Argon laser photocoagulation tor neovascular maculopathy [published correction appears in Arch Ophthalmol. 1992; 110:761]. Arch Ophthalmol. 1991;109:1109-1114.
5. Macular Photocoagulation Study Group. Laser photocoagulation tor juxtafoveal choroidal neovascularization. Arch Ophthalmol. 1994;112:500-509.
6. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol. 1991;109:1220-1231.
7. Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal recurrent neovascular lesions in age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol. 1991;109:1232-1241.
8. Macular Photocoagulation Study Group. Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol. 1994;112:480-488.
9. Schmidt-Erfurth U, Hasan T, Schomacker K, Flotte T, Birngruber R. In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascualrization. Lasers Surg Med. 1995;17:178-188.
10. Schmidt-Erfurth U, Hasan T, Gragoudas E, Michaud N, Flotte TJ, Birngruber R. Vascular targeting in photodynamic occlusion of subretinal vessels. Ophthalmology. 1994;101:1953-1961.
11. Miller JW, Walsh AW, Kramer M, et al. Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-derived benzoporphyrin. Arch Ophthalmol. 1995;113:810-818.
12. Kramer M, Miller JW, Michaud N, et al. Liposomal benzoporphyrin derivative verteporfin in photodynamic therapy. Ophthalmology. 1996;103:427-438.
13. Husain D, Miller JW, Michaud N, Connolly E, Flotte TJ, Gragoudas ES. Intravenous infusion of liposomal benzoporphyrin derivative for photodynamic therapy of experimental choroidal neovascularization. Arch Ophthalmol. 1996;114:978-985.
14. Schmidt-Erfurth U, Miller J, Sickenberg M, et al. Photodynamic therapy of subfoveal choroidal neovascularization: clinical and angiographic examples. Graefes Arch Clin Exp Ophthalmol. 1998;236:365-374.
15. Reinke MH, Canakis C, Husain D, et al. Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomologous monkey. Ophthalmology. In press.
16. Miller JW, Schmidt-Erfurth U, Sickenberg M, et al. Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of a single treatment in a phase 1 and 2 study. Arch Ophthalmol. 1999;117:1161-1173.
17. Submacular Surgery Trials Research Group. SST Manual of Procedures. Springfield, Va: National Technical Information Services; 1998. NTIS Accession No. PB98 166648.
18. Macular Photocoagulation Study Group. Subfoveal neovascular lesions in age-related macular degeneration. Arch Ophthalmol. 1991;109:1242-1257.
19. Schmidt-Erfurth U. Indocyanine green angiography and retinal sensitivity after photodynamic therapy of subfoveal choroidal neovascularization. Semin Ophthalmol. 1999;14:35-44.
20. Lutty GA, McLeod DS, Merges C, Diggs A, Plouet J. Localization of vascular endothelial growth factor in human retina and choroid. Arch Ophthalmol. 1996; 114:971-977.
21. Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest Ophthalmol Vis Sci. 1996;37:1929-1934.
22. van der Schaft TL, Mooy CM, de Bruijn WC, Oron FG, Mulder PC, de Jong PTVM. Histologic features of the early stages of age-related macular degeneration. Ophthalmology. 1992;99:278-286.
23. Spraul CW, Lang GE, Grossniklaus HE. Morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci. 1996;37:2724-2735.
24. Green WR, Enger C. Age-related macular degeneration histopathologic studies. Ophthalmology. 1993;100:1519-1535.
25. Miller H, Miller B, Ryan SJ. The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest Ophthalmol Vis Sci. 1986;27:1644-1652.