Expression of PKC β1 and PKC β2 in early gastric carcinoma

World Chinese Journal of Digestology

Volumn 11, Issue 9, 2003, Pages 1286-1289

  Feng, Rui E ^a   Chen, Jie ^a   Cui, Quan Cai ^a   Zhan, Yang ^a   Wang, Zhen Yu ^b  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C BETA2; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; DYSPLASIA; EPITHELIUM CELL; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; LYMPHOID CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RANDOMIZATION; STOMACH; STOMACH CARCINOMA; STOMACH MUCOSA;

EID: 0141683496     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Buchner K. The role of protein kinase C in the regulation of cell growth and in signalling to the cell nucleus. J Cancer Res Clin Oncol 2000;126:1-11
2. Way D, Smith S, Sivendran S, Chie L, Kanovsky M, Brandt-Rauf PW, Chung DL, Michl J, Pincus MR. A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti-ras peptide. Cancer Chemother Pharmacol 2002;49:429-437
3. Goekjian PG, Jirousek MR. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin Investig Drugs 2001;10:2117-2140
4. Carter CA. Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer. Curr Drug Targets 2000;1:163-183
5. Garcia-Fernandez LF, Losada A, Alcaide V, Alvarez AM, Cuadrado A, Gonzalez L, Nakayama K, Nakayama KI, Fernandez-Sousa JM, Munoz A, Sanchez-Puelles JM. Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene 2002;21:7533-7544
6. Sagawa N, Fujita H, Banno Y, Nozawa Y, Katoh H, Kuzumaki N. Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10. Br J Cancer 2003;88:606-612
7. Jarzabek K, Laudanski P, Dzieciol J, Dabrowska M, Wolczynski S. Protein kinase C involvement in proliferation and survival of breast cancer cells. Folia Histochem Cytobiol 2002;40:193-194
8. Masanek U, Stammler G, Volm M. Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides. J Exp Ther Oncol 2002;2:37-41
9. Cornford P, Evans J, Dodson A, Parsons K, Woolfenden A, Neoptolemos J, Foster CS. Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer. Am J Pathol 1999;154:137-144
10. Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 2001;61:1375-1381
11. Zhu GH, Wong BC, Slosberg ED, Eggo MC, Ching CK, Yuen ST, Lai KC, Soh JW, Weinstein IB, Lam SK. Overexpression of protein kinase C-beta1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 2000;118:507-514
12. Atten MJ, Attar BM, Milson T, Holian O. Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C: mediated mechanism. Biochem Pharmacol 2001;62:1423-1432
13. Teicher BA, Menon K, Alvarez E, Galbreath E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human HT-29 colon carcinoma and human CaKi1 renal cell carcinoma xenografts. Anticancer Res 2001;21:3175-3184
14. Han Y, Han ZY, Zhou XM, Shi R, Zheng Y, Shi YQ, Miao JY, Pan BR, Fan DM. Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines. World J Gastroenterol 2002;8:441-445
15. Uchida N, Okamura S, Kuwano H. Protein kinase C activity in human gastric carcinoma. Oncol Rep 2000;7:793-796
16. Wu D, Foreman TL, Gregory CW, McJilton MA, Wescott GG, Ford OH, Alvey RF, Mohler JL, Terrian DM. Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res 2002;62:2423-2429
17. Schondorf T, Kurbacher CM, Becker M, Warm M, Kolhagen H, Gohring UJ. Heterogeneity of protein kinase C activity and PKC-zeta expression in clinical breast carcinomas. Clin Exp Med 2001;1:1-8
18. Masso-Welch PA, Winston JS, Edge S, Darcy KM, Asch H, Vaughan MM, Ip MM. Altered expression and localization of PKC eta in human breast tumors. Breast Cancer Res Treat 2001;68:211-223
19. Clark AS, West KA, Blumberg PM, Dennis PA. Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells:PKCdelta promotes cellular survival and chemotherapeutic resistance. Cancer Res 2003;63:780-786
20. Ding L, Wang H, Lang W, Xiao L. Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. J Biol Chem 2002;277:35305-35313
21. Langzam L, Koren R, Gal R, Kugel V, Paz A, Farkas A, Sampson SR. Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. Am J Clin Pathol 2001;116:377-385
22. Izawa M, Teramachi K. Down-regulation of protein kinase C activity by sorbitol rapidly induces apoptosis in human gastric cancer cell lines. Apoptosis 2001;6:353-358