Potent antimalarial febrifugine analogues against the Plasmodium malaria parasite

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2563-2570

  Kikuchi, Haruhisa ^a   Tasaka, Hidehisa ^a   Hirai, Shingo ^a   Takaya, Yoshiaki ^a   Iwabuchi, Yoshiharu ^b   Ooi, Hidenori ^b   Hatakeyama, Susumi ^b   Kim, Hye Sook ^c   Wataya, Yusuke ^c   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 HYDROXYHEXAHYDROPYRIDO[1,2 C][1,3]OXAZIN 3 YLMETHYL) 4(3H) QUINAZOLINONE; 3 (5 METHOXYMETHYLOXYHEXAHYDROPYRIDO[1,2 C][1,3]OXAZIN 3 YLMETHYL) 4(3H) QUINAZOLINONE; 3 [3 (3 HYDROXY 2 PIPERIDINYL) 2 HYDROXYPROPYL] 4(3H) QUINAZOLINONE; 3 [3 (3 OXO 2 PIPERIDINYL) 2 OXOPROPYL] 4(3H) QUINAZOLINONE; ALKALOID; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; DICHROA FEBRIFUGA EXTRACT 1; DICHROA FEBRIFUGA EXTRACT 2; FEBRIFUGINE; FEBRIFUGINE DERIVATIVE; ISOFEBRIFUGINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DICHROA FEBRIFUGA; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MEDICINAL PLANT; MOUSE; NONHUMAN; OXIDATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RACEMIC MIXTURE; REDUCTION; STRUCTURE ACTIVITY RELATION; VOMITING;

ANIMALS; ANTIMALARIALS; CELL LINE; MALARIA; MICE; PIPERIDINES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037030685     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010448q     Document Type: Article

References (16)

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