Leukemia in severe congenital neutropenia: Defective proteolysis suggests new pathways to malignancy and opportunities for therapy

Cancer Investigation

Volumn 21, Issue 4, 2003, Pages 579-587

  Horwitz, Marshall ^a   Li, Feng Qian ^a   Albani, Dalila ^a   Duan, Zhijun ^a   Person, Richard E ^a   Meade White, Kimberly ^a   Benson, Kathleen F ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Agranulocytosis; ELA2; Kostmann Syndrome; Leukemia; Neutropenia; Neutrophilelastase

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; LEUKOCYTE ELASTASE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; AUTOSOMAL DOMINANT DISORDER; CARCINOGENESIS; CELLULAR DISTRIBUTION; CHROMOSOME 19P; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ELA2 GENE; ENZYME LOCALIZATION; GENE; GENE MUTATION; HEMATOPOIESIS; HUMAN; MALIGNANT TRANSFORMATION; MOLECULAR GENETICS; MYELODYSPLASIA; NEUTROPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SEVERE CONGENITAL NEUTROPENIA; TREATMENT PLANNING; WISKOTT ALDRICH SYNDROME;

DIAGNOSIS, DIFFERENTIAL; HEMATOPOIESIS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKOCYTE ELASTASE; NEURAL TUBE DEFECTS; NEUTROPENIA; PROTEINS; RISK FACTORS;

EID: 0141676665     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1081/CNV-120022378     Document Type: Review

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