Is there a psychoneuroimmunological pathway between alexithymia and immunity? Immune and physiological correlates of alexithymia

Biomedicine and Pharmacotherapy

Volumn 57, Issue 7, 2003, Pages 292-295

  Guilbaud, Olivier ^a   Corcos, Maurice ^a   Hjalmarsson, Linnea ^a   Loas, Gwenolé ^b   Jeammet, Philippe ^a  

^a INSTITUT MUTUALISTE MONTSOURIS   (France)

^b Hôpital Pinel   (France)

Author keywords

Alexithymia; Immunity; Stress

Indexed keywords

ALEXITHYMIA; CELLULAR IMMUNITY; EMOTION; HORMONE RELEASE; HUMAN; IMMUNITY; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; PSYCHOSOMATIC DISORDER; REVIEW; STRESS; SYMPATHETIC TONE; TH1 CELL; TH2 CELL;

EID: 0141671856     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(03)00085-4     Document Type: Article

References (35)

1. Ackerman K.D., Martino M., Heyman R., Moyna N.M., Rabin B.S. Stressor-induced alteration of cytokine production in multiple sclerosis patients and controls. Psychosom. M. 60:1998;484-491.
2. Agarwal S.K., Marshall G.D. Jr. Dexamethasone promotes type 2 cytokine production primarily through inhibition of type 1 cytokines. J. Interferon Cytokine Res. 21:2001;147-155.
3. Caioppo J.T., Berntson G.C., Malarkey W.B., Kiecolt-Glaser J.K., Sheridan J.F., Poehlmann K.M., Burleson M.H., Ernst J.M., Hawkley L.C., Glaser R. Autonomic, neuroendocrine, and immune responses to psychological stress: the reactivity hypothesis. Ann. New York Acad. Sci. 840:1998;664-673.
4. Corcos M., Guilbaud O., Speranza M., Paterniti S., Loas G., Stephan P., Jeammet P. Alexithymia and depression in eating disorders. Psychiatry Res. 93:(3):2000;265-268.
5. Corcos M., Guilbaud O., Paterniti S., Curt F., Hjalmarsson L., Moussa M., Chambry J., Loas G., Chaouat G., Jeammet P. Correlation between serum levels of interleukin-4 and alexithymia scores in healthy female subjects: preliminary findings. Psychoneuroendocrinology. 2003;. (in press).
6. Dewaraja R., Tanigawa T., Araki S., Nakata A., Kawamura N., Ago Y., Sasaki Y. Decreased cytotoxic lymphocyte counts in alexithymia. Psychother. Psychosom. 66:1997;83-86.
7. Elenkov I.J., Papanicolaou D.A., Wilder R.L., Chrousos G.P. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc. Assoc. Am. Physicians. 108:1996;374-381.
8. Fukunishi I., Sei H., Morita Y., Rahe R.H. Sympathetic activity in alexithymics with mother's low care. J. Psychosom. Res. 46:1999;579-589.
9. Freyberger H. Supportive psychotherapeutic techniques in primary and secondary alexithymia. Psychother. Psychosom. 28:1977;337-342.
10. Friedlander L., Lumley M.A., Farchione T., Doyal G. Testing the alexithymia hypothesis: physiological and subjective responses during relaxation and stress. J. Nerv. Ment. Dis. 185:(4):1997;233-239.
11. Glaser R., MacCallum R.C., Laskowski B.F., Malarkey W.B., Sheridan J.F., Kiecolt-Glaser J.K. Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging. J. Gerontol. A. Biol. Sci. Med. Sci. 56:2001;M477-M482.
12. Goebels M.U., Mills P.J., Irwin M.R., Ziegler M.G. Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways. Psychosom. M. 62:2000;591-598.
13. Gundel H., Greiner A., Ceballos-Baumann A.O., Von Rad M., Forstl H., Jahn T. Increased level of tonic sympathetic arousal in high versus low alexithymic cervical dystonia patients. Psychother. Psychosom. 52:2002;461-468.
14. Haviland M.G., Hendryx M.S., Shaw D.G., Henry J.P. Alexithymia in women and men hospitalized for psychoactive substance dependence. Compr. Psychiatry. 35:(2):1994;124-128.
15. Herbert T.B., Cohen S. Stress and immunity in humans: a meta-analytic review. Psychosom. M. 55:(4):1993;364-379.
16. Infrasca R. Alexithymia, neurovegetative arousal and neuroticism. An experimental study. Psychother. Psychosom. 66:(5):1997;276-280.
17. Iwakabe K., Shimada M., Ohta A., Yahata T., Ohmi Y., Habu S., Nishimura T. The restraint stress drives a shift in Th1/Th2 balance toward Th2-dominant immunity mice. Immunol. Lett. 62:1998;39-43.
18. Larson M.R., Ader R., Moynihan J.A. Heart rate, neuroendocrine, and immunological reactivity in response to an acute laboratory stressor. Psychosom. M. 63:2001;493.
19. Lindholm T., Lehtinen V., Hyyppa M.T., Puukka P. Alexithymic features in relation to the dexamethasone suppression test in a Finnish population sample. Am. J. Psychiatry. 147:1990;1216-1219.
20. Loas G., Fremaux D., Otmani O., Lecercle C., Jouvent R. Relationships between the emotional and cognitive components of alexithymia and dependency in alcoholics. Psychiatry Res. 96:2000;63-74.
21. Lumley M.A., Stettner L., Wehmer F. How are alexithymia and physical illness linked? A review and critique of pathways. J. Psychosom. Res. 41:(6):1996;505-518.
22. Madden K.S., Sanders V.M., Felten D.L. Catecholamine influences and sympathetic neural modulation of immune responsiveness. A.R. Pharmacol. Toxicol. 35:1995;417.
23. Marshall G.D., Agarwall S.K., Lloyd C., Cohen L., Henninger E.M., Morris G.J. Cytokine dysregulation associated with exam stress in healthy medical students. Brain Behav. Immun. 12:1998;297-307.
24. Martin J.B., Pihl R.O. Influence of alexithymic characteristics on physiological and subjective stress responses in normal individuals. Psychother. Psychosom. 45:1986;66-67.
25. Newton T.L., Contrada R.J. Repressive coping and verbal-autonomic response dissociation: the influence of social context. J Pers Soc Psychol. 62:1992;159-167.
26. Papciak A.S., Feuerstein M., Spiegel J.A. Stress reactivity in alexithymia: decoupling of physiological and cognitive responses. J. Hum. Stress. 11:(3):1985;135-142.
27. Pert C.B., Ruff M.R., Weber R.J., Herkenham M. Neuropeptides and their receptors: a psychosomatic network. J. Immunol. 135:1985;792-797.
28. Peters M.L., Godaert G.L., Ballieux R.E., Brosschot J.F., Sweep F.C.G., Swinkels L.M.J., Van Vliet M., Heijnen C.J. Immune responses to experimental stress: effects of mental effort and uncontrollability. Psychosom. M. 61:1999;513-524.
29. Rabavilas A.D. Electrodermal activity in low and high alexithymia neurotic patients. Psychother. Psychosom. 47:1987;101-104.
30. Shea J.D., Burton R., Girgis A. Negative affect, absorption, and immunity. Physiol. Behav. 53:1993;449-457.
31. Sifneos P.E. The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother. Psychosom. 22:1973;255-262.
32. Spivak B., Shohat B., Mester R., Avraham S., Gild-Ad I., Bleich A., Valevski A., Weizman A. Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder. Biol. Psychiatry. 42:1997;345-348.
33. Stone L.A., Nielson K.A. Intact physiological response to arousal with impaired emotional recognition in alexithymia. Psychother. Psychosom. 70:(2):2001;92-102.
34. Todarello O., Casamassima A., Marinaccio M., La Pesa M.W., Caradonna L., Valentino L., Marinaccio L. Alexithymia, immunity and cervical intraepithelial neoplasia: a pilot study. Psychother. Psychosom. 61:1994;199-204.
35. Todarello O., Casamassima A., Daniele S., Marinaccio M., Fanciullo F., Valentino L., Tedesco N., Wiesel S., Simone G., Marinaccio L. Alexithymia, immunity and cervical intraepithelial neoplasia: replication. Psychother. Psychosom. 66:1997;208-213.