Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes

Ophthalmic Research

Volumn 31, Issue 3, 1999, Pages 229-235

  Burgalassi, Susi ^a   Panichi, Luana ^a   Chetoni, Patrizia ^a,b   Saettone, M Fabrizio ^a,b   Boldrini, Enrico ^c  

^a UNIVERSITY OF PISA   (Italy)

^b Inter Dept Ctr Ocular P   (Italy)

^c Farmigea SpA   (Italy)

Author keywords

Atropine sulphate; Corneal staining; Dry eye model; Ferning test; Fluorescein; Hydroxypropylmethylcellulose; Rabbits; Schirmer I test; Sodium hyaluronate; Sodium polyacrylate; Tamarind gum; Tear substitutes

Indexed keywords

ARTIFICIAL TEAR; ATROPINE; BENZALKONIUM CHLORIDE; CETRIMIDE; FLUORESCEIN; HYALISTIL; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; LACRISIFI; POLYACRYLIC ACID; POLYSACCHARIDE; THIOMERSAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG FORMULATION; DRY EYE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STAINING; TEAR FILM; TOPICAL DRUG ADMINISTRATION;

ANIMALS; DISEASE MODELS, ANIMAL; DRY EYE SYNDROMES; EVALUATION STUDIES; MALE; OPHTHALMIC SOLUTIONS; POLYMERS; RABBITS; TEARS;

EID: 0032919802     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055537     Document Type: Article

References (27)

1. Holly FJ, Lemp MA: Tear physiology and dry eyes. Surv Ophthalmol 1977;22:69-87.
2. Jaanus SD: Lubricants and other preparations for ocular surface disease; in Bartlett JD, Jaanus SD (eds): Clinical Ocular Pharmacology. Boston, Butterworth-Heinemann, 1995, pp 355-367.
3. Holly FJ, Patten JT, Dohlman CH: Surface activity of aqueous tear components in dry eye patients and normals. Exp Eye Res 1977;24:479-491.
4. Holly FJ: Formation and rupture of the tear film. Exp Eye Res 1973;15: 515-525.
5. Cope C, Dilly PN, Kaura R, Tiffany JM: Wettability of the corneal surface: A reappraisal. Curr Eye Res 1986;5:777-785.
6. Tiffany JM: Composition and biophysical properties of the tear film: Knowledge and uncertainty; in Sullivan DA (ed): Lacrimal Gland, Tear Film, and Dry Eye Syndromes. New York, Plenum Press, 1994, pp 231-238.
7. Lemp MA: Tear substitutes in the treatment of dry eyes. Int Ophthalmol Clin 1973;13:145-152.
8. Shively CD: Development of clinically acceptable artificial tear formulations; in Robinson JR (ed): Ophthalmic Drug Delivery Systems. Washington, American Pharmaceutical Association, 1980, pp 119-137.
9. Shively CD, McDonald T: Simultaneous wetting of corneal and rigid contact lens surfaces through polymer adsorption. III. Ocular irritation and corneal protective studies. Contacto 1977;21:32-36.
10. Gilbard JP, Rossi SR, Gray KL: A new rabbit model for keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 1987;28:225-228.
11. Gilbard JP, Rossi SR, Gray KL, Hanninen LA, Kenyon KR: Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 1988;29:374-378.
12. Fujihara T, Nagano T, Nakamura M, Shirasawa E: Establishment of a rabbit short-term dry eye model. J Ocul Pharmacol 1995;11:503-508.
13. Caruso P, Cavaliere S, Spampinato D, Dal Bello A, Franco L, Cavallaro F, Drago F, Reibaldi A: Uso di una frazione dell'acido ialuronico nella sindrome dell'occhio secco e nella patologia corneale: uno studio sperimentale e clinico. Atti I° Congr Naz Farmacol Ocul, Firenze, 1988, pp 177-182.
14. Kaswan RL, Salisbury MA, Ward DA: Spontaneous canine keratoconjunctivitis sicca: A useful model for human keratoconjunctivitis sicca: Treatment with cyclosporine eye drops. Arch Ophthalmol 1989;107: 1210-1216.
15. Jabs DA, Enger C, Prendergast RA: Murine models of Sjögren's syndrome. Invest Ophthalmol Vis Sci 1991;32:371-380.
16. Berman ER: Tears; in Berman ER (ed): Biochemistry of the Eye. New York, Plenum Press, 1991, p 70.
17. Schirmer O: Studien zur Physiologie und Pathologie der Tränenabsonderung und Tränenabfuhr. Arch Klin Ophthalmol 1903;56:197-291.
18. Crandall DC, Leopold IH: The influence of systemic drugs on tear constituents. Ophthalmology 1979; 86:115-125.
19. Erickson OF: Drug influences on lacrimal lysozyme production. Stanford Med Bull 1960;18:34-39.
20. Mader TH, Stulting RD: Keratoconjunctivitis sicca caused by diphenoxylate hydrochloride with atropine sulphate (Lomotil). Am J Ophthalmol 1991;11:377-378.
21. Nagai T, Machida Y, Suzuki Y, Ikura H: Method and preparation for administration to the mucosa of the oral or nasal cavity. US Patent 4,226,848; October 7, 1980.
22. Smart JD, Kellaway IW, Worthington HEC: An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J Pharm Pharmacol 1984;36:295-299.
23. Kogbe O, Liotet S, Tiffany JM: Factors responsible for tear ferning. Cornea 1991;10:433-444.
24. Tabbara KF, Okumoto M: Ocular ferning test: A qualitative test for mucus deficiency. Ophthalmology 1982;89:712-714.
25. Rolando M: Tear mucus ferning test in normal and keratoconjunctivitis sicca eyes. Chibret Int J Ophthalmol 1984;2:32-41.
26. Filippello M, Scimone G, Mazzone MG, Santocono M, Pantaleoni GC: Ferning test and artificial tears: Comparative evaluation; in Hurwitz J, Miglior M, Spinelli D, van Bijsterveld OP (eds): Lacrimal System, Proc Symp Lacrimal System, Toronto, June 25, 1994. Amsterdam, Kugler & Ghedini, 1995, pp 97-106.
27. Burgalassi S, Panichi L, Saettone MF, Jacobsen J, Rassing MR: Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine. Int J Pharm 1996;133:1-7.