Liquid chromatography-tandem mass spectrometric quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human peripheral blood mononuclear cells (PBMC): Practical approaches to PBMC preparation and PBMC assay design for high-throughput analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 795, Issue 2, 2003, Pages 273-289

  Jemal, Mohammed ^a   Rao, Satish ^b,d   Gatz, Michael ^c   Whigan, Daisy ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b MDS Inc   (Canada)

^c Bioreclamation Inc   (United States)

^d SCIOS INC   (United States)

Author keywords

Atazanavir; Peripheral blood mononuclear cells

Indexed keywords

BIOASSAY; BLOOD; CALIBRATION; CELLS; COMPOSITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; QUALITY CONTROL;

BLOOD CELLS;

ENZYME KINETICS;

ATAZANAVIR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; BLOOD SAMPLING; CALIBRATION; CELL ASSAY; CELL COUNT; CONTROLLED STUDY; DEVICE; DRUG STRUCTURE; HUMAN; HUMAN CELL; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MOLECULAR WEIGHT; MONONUCLEAR CELL; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; ROOM TEMPERATURE; SAMPLING; SOLID PHASE EXTRACTION; STANDARDIZATION; STEREOCHEMISTRY; SYNTHESIS; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 0141649213     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00589-0     Document Type: Article

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