Rh-catalyzed kinetic resolution of enynes and highly enantioselective formation of 4-alkenyl-2,3-disubstituted tetrahydrofurans

Journal of the American Chemical Society

Volumn 125, Issue 38, 2003, Pages 11472-11473

  Lei, Aiwen ^a   He, Minsheng ^a   Zhang, Xumu ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; METAL; TETRAHYDROFURAN DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CYCLIZATION; ENANTIOSELECTIVITY; ISOMERISM; KINETICS; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 0141645606     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0351950     Document Type: Article

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27. The trans configuration of cycloisomerization products was identified by nOe experimentations of compounds 8a, and 8b.
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30. During the investigation of substrate scopes, substrates 3a and 3c were successfully employed in the kinetic resolution protocol with (S)-BINAP. Some others substrates S1, S3, S5 (in Supporting Information 2) were examined. and the excellent selectivity was observed as expected. Please see details in Supporting Information 2.