Sensitization of adenylate cyclase: A general mechanism of neuroadaptation to persistent activation of Gαi/o-coupled receptors?

Life Sciences

Volumn 73, Issue 23, 2003, Pages 2913-2925

  Johnston, Christopher A ^a   Watts, Val J ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Adenylate cyclase; Drug abuse; G proteins; Heterologous sensitization

Indexed keywords

ADENOSINE RECEPTOR; ADENYLATE CYCLASE; ALPHA 2 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; COCAINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; ISOENZYME; METHAMPHETAMINE; MORPHINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; OPIATE; PERTUSSIS TOXIN; PROTEIN SUBUNIT; SIGMA OPIATE RECEPTOR; SOMATOSTATIN RECEPTOR;

ADAPTATION; ADDICTION; BRAIN REGION; DRUG ABUSE; DRUG DEPENDENCE; DRUG TOLERANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; EXPERIMENTAL MODEL; HUMAN; LOCUS CERULEUS; NERVE CELL PLASTICITY; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENSITIZATION; SHORT SURVEY;

EID: 0141644358     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00703-3     Document Type: Review

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