Perioperative administration of the α2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression

Pain

Volumn 105, Issue 1-2, 2003, Pages 247-254

  Lavand'homme, P M ^a   Eisenach, J C ^b  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Clonidine; Cytokine; Interleukin 1 ; Neuropathic pain; Tumor necrosis ; 2 Adrenergic agonist

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; CYTOKINE; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; INTERLEUKIN 1; TGFB1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERSENSITIVITY; MALE; NERVE INJURY; NERVE LIGATION; NONHUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SCIATIC NERVE; WOUND CLOSURE; ANIMAL; DRUG COMBINATION; DRUG EFFECT; HYPERALGESIA; INJURY; LIGATION; METABOLISM; MOTOR ACTIVITY; PAIN THRESHOLD; PEROPERATIVE CARE; POSTOPERATIVE CARE; PREOPERATIVE CARE; PSYCHOLOGICAL ASPECT; SPRAGUE DAWLEY RAT; STIMULATION; WISTAR RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BEHAVIOR, ANIMAL; CLONIDINE; CYTOKINES; DRUG COMBINATIONS; HYPERALGESIA; IMIDAZOLES; INDOLES; INTERLEUKIN-1; INTRAOPERATIVE CARE; LIGATION; MALE; MOTOR ACTIVITY; PAIN THRESHOLD; PHYSICAL STIMULATION; POSTOPERATIVE CARE; PREOPERATIVE CARE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SCIATIC NERVE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES;

EID: 0141626843     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(03)00221-5     Document Type: Article

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