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Volumn 32, Issue 3, 2003, Pages 223-230

Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice

Author keywords

Atopic dermatitis; Cytokines; Epicutaneous sensitization; Immunoglobulin; T helper cells

Indexed keywords

HEMOCYANIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 13;

EID: 0141625865     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(03)00106-3     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 0033791427 scopus 로고    scopus 로고
    • Transcriptional regulation of Th1/Th2 polarization
    • Rengarajan J., Szabo S.J., Glimcher L.H. Transcriptional regulation of Th1/Th2 polarization. Immunol. Today. 21:2000;479-483.
    • (2000) Immunol. Today , vol.21 , pp. 479-483
    • Rengarajan, J.1    Szabo, S.J.2    Glimcher, L.H.3
  • 2
    • 0034176196 scopus 로고    scopus 로고
    • Localization of Th-cell subsets in inflammation: Differential thresholds for extravasation of Th1 and Th2 cells
    • D'Ambrosio D., Iellem A., Colantonio L., Clissi B., Pardi R., Sinigaglia F. Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells. Immunol. Today. 21:2000;183-186.
    • (2000) Immunol. Today , vol.21 , pp. 183-186
    • D'Ambrosio, D.1    Iellem, A.2    Colantonio, L.3    Clissi, B.4    Pardi, R.5    Sinigaglia, F.6
  • 3
    • 0035919526 scopus 로고    scopus 로고
    • Efficient induction of antigen-specific, T helper type 1-mediated immune responses by intramuscular injection with ovalbumin/interleukin-18 fusion DNA
    • Kim S.H., Cho D., Hwang S.Y., Kim T.S. Efficient induction of antigen-specific, T helper type 1-mediated immune responses by intramuscular injection with ovalbumin/interleukin-18 fusion DNA. Vaccine. 19:2001;4107-4114.
    • (2001) Vaccine , vol.19 , pp. 4107-4114
    • Kim, S.H.1    Cho, D.2    Hwang, S.Y.3    Kim, T.S.4
  • 4
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subset
    • Mosmann T.R., Sad S. The expanding universe of T-cell subset. Immunol. Today. 17:1996;138-146.
    • (1996) Immunol. Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 6
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • Cherwinski H.M., Schumacher J.H., Brown K.D., Mosmann T.R. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1987;1229-1244.
    • (1987) J. Exp. Med. , vol.166 , pp. 1229-1244
    • Cherwinski, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 7
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subset
    • O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subset. Immunity. 8:1998;275-283.
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 8
    • 0026719193 scopus 로고
    • Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse
    • Renz H., Smith H.R., Henson J.E., Ray B.S., Irvin C.G., Gelfand E.W. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89:1992;1127-1138.
    • (1992) J. Allergy Clin. Immunol. , vol.89 , pp. 1127-1138
    • Renz, H.1    Smith, H.R.2    Henson, J.E.3    Ray, B.S.4    Irvin, C.G.5    Gelfand, E.W.6
  • 9
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner S.L., Locksley R.M. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:1995;151-177.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 10
    • 0030963614 scopus 로고    scopus 로고
    • Induction of Th1 and Th2 CD4+ T cell responses: The alternative approaches
    • Constant S.L., Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 151:1997;297-322.
    • (1997) Annu. Rev. Immunol. , vol.151 , pp. 297-322
    • Constant, S.L.1    Bottomly, K.2
  • 11
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th) 2 cells induced by continuous administration of low dose soluble proteins to normal and beta (2)-microglobulin-deficient BALB/c mice
    • Guery J.C., Galbiati F., Smiroldo S., Adorini L. Selective development of T helper (Th) 2 cells induced by continuous administration of low dose soluble proteins to normal and beta (2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:1996;485-497.
    • (1996) J. Exp. Med. , vol.183 , pp. 485-497
    • Guery, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 12
    • 0031227816 scopus 로고    scopus 로고
    • Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection
    • Guery J.C., Galbiati F., Smiroldo S., Adorini L. Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection. J. Immunol. 159:1997;2147-2153.
    • (1997) J. Immunol. , vol.159 , pp. 2147-2153
    • Guery, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 14
    • 0034686578 scopus 로고    scopus 로고
    • Alteration at a single amino acid residue in the T cell receptor α chain complementarily determining region 2 changes the differentiation of naïve CD4T cells in response to antigen from T helper cell type 1 (Th1) to Th2
    • Blander J.M., Sant'Angelo D.B., Bottomly K., Janeway C.A. Alteration at a single amino acid residue in the T cell receptor α chain complementarily determining region 2 changes the differentiation of naïve CD4T cells in response to antigen from T helper cell type 1 (Th1) to Th2. J. Exp. Med. 191:2000;2065-2074.
    • (2000) J. Exp. Med. , vol.191 , pp. 2065-2074
    • Blander, J.M.1    Sant'Angelo, D.B.2    Bottomly, K.3    Janeway, C.A.4
  • 15
    • 0026527867 scopus 로고
    • Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and non-allergic individuals
    • Kapsenberg M.L., Wierenge E.A., Stiekema F.E.M., Tiggelman A.M.B.C., Bos J.D. Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and non-allergic individuals. J. Invest. Dermatol. 98:1992;59-63.
    • (1992) J. Invest. Dermatol. , vol.98 , pp. 59-63
    • Kapsenberg, M.L.1    Wierenge, E.A.2    Stiekema, F.E.M.3    Tiggelman, A.M.B.C.4    Bos, J.D.5
  • 16
    • 0022202912 scopus 로고
    • Isolation and characterization of Ni-specific T cell clone from patients with Ni-contact dermatitis
    • Sinigaglia F., Scheidegger D., Garotta G., Scheper R., Pletscher M., Lanzavecchia A. Isolation and characterization of Ni-specific T cell clone from patients with Ni-contact dermatitis. J. Immunol. 135:1985;3929-3932.
    • (1985) J. Immunol. , vol.135 , pp. 3929-3932
    • Sinigaglia, F.1    Scheidegger, D.2    Garotta, G.3    Scheper, R.4    Pletscher, M.5    Lanzavecchia, A.6
  • 17
    • 0031225486 scopus 로고    scopus 로고
    • Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile
    • Kitagaki H., Ono N., Hayakawa K., Kitazawa T., Watanabe K., Shiohara T. Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J. Immunol. 159:1997;2484-2491.
    • (1997) J. Immunol. , vol.159 , pp. 2484-2491
    • Kitagaki, H.1    Ono, N.2    Hayakawa, K.3    Kitazawa, T.4    Watanabe, K.5    Shiohara, T.6
  • 18
    • 0028351398 scopus 로고
    • The molecular basis of metal recognition by T cells
    • Sinigaglia F. The molecular basis of metal recognition by T cells. J. Invest. Dermatol. 102:1994;398-401.
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 398-401
    • Sinigaglia, F.1
  • 19
    • 0029081178 scopus 로고
    • Contact sensitivity as a model for T-cell activation in skin
    • Enk A.H., Katz S.I. Contact sensitivity as a model for T-cell activation in skin. J. Invest. Dermatol. 105:1995;80S-83S.
    • (1995) J. Invest. Dermatol. , vol.105
    • Enk, A.H.1    Katz, S.I.2
  • 20
    • 0028831456 scopus 로고
    • Characterrization of epitopes recognized by hapten-specific CD4+ T cells
    • Cavani A., Hackett C.J., Wilson K.J., Rothbard J.B., Katz S.I. Characterrization of epitopes recognized by hapten-specific CD4+ T cells. J. Immunol. 154:1995;1232-1238.
    • (1995) J. Immunol. , vol.154 , pp. 1232-1238
    • Cavani, A.1    Hackett, C.J.2    Wilson, K.J.3    Rothbard, J.B.4    Katz, S.I.5
  • 21
    • 0029991646 scopus 로고    scopus 로고
    • Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice
    • Wang L.F., Lin J.Y., Hsieh K.H., Lin R.H. Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J. Immunol. 156:1996;4079-4082.
    • (1996) J. Immunol. , vol.156 , pp. 4079-4082
    • Wang, L.F.1    Lin, J.Y.2    Hsieh, K.H.3    Lin, R.H.4
  • 22
    • 0035871759 scopus 로고    scopus 로고
    • Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung
    • Hurst S.D., Seymour B.W., Muchamuel T., Kurup V.P., Coffman R.L. Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung. J. Immunol. 166:2001;4922-4930.
    • (2001) J. Immunol. , vol.166 , pp. 4922-4930
    • Hurst, S.D.1    Seymour, B.W.2    Muchamuel, T.3    Kurup, V.P.4    Coffman, R.L.5
  • 23
    • 0031881256 scopus 로고    scopus 로고
    • Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response
    • Kondo H., Ichikawa Y., Imokawa G. Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response. Eur. J. Immunol. 28:1998;769-779.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 769-779
    • Kondo, H.1    Ichikawa, Y.2    Imokawa, G.3
  • 24
    • 0032523018 scopus 로고    scopus 로고
    • Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice
    • Spergel J.M., Mizoguchi E., Brewer J.P., Martin T.R., Bhan A.K., Geha R.S. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J. Clin. Invest. 101:1998;1614-1622.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1614-1622
    • Spergel, J.M.1    Mizoguchi, E.2    Brewer, J.P.3    Martin, T.R.4    Bhan, A.K.5    Geha, R.S.6
  • 25
  • 26
    • 0034108370 scopus 로고    scopus 로고
    • Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
    • Herrick C.A., MacLeod H., Glusac E., Tigelaar R.E., Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J. Clin. Invest. 105:2000;765-775.
    • (2000) J. Clin. Invest. , vol.105 , pp. 765-775
    • Herrick, C.A.1    MacLeod, H.2    Glusac, E.3    Tigelaar, R.E.4    Bottomly, K.5
  • 27
    • 0034602670 scopus 로고    scopus 로고
    • Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis
    • Seo N., Tokura Y., Nishijima T., Hashizume H., Furukawa F., Takigawa M. Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis. Proc. Natl. Acad. Sc. 97:2000;371-376.
    • (2000) Proc. Natl. Acad. Sc. , vol.97 , pp. 371-376
    • Seo, N.1    Tokura, Y.2    Nishijima, T.3    Hashizume, H.4    Furukawa, F.5    Takigawa, M.6
  • 29
    • 0033168615 scopus 로고    scopus 로고
    • Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ positive T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
    • Akdis M., Simon H.U., Weigl L., Kreyden O., Blaser K., Akdis C.A. Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ positive T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J. Immunol. 163:1999;466-475.
    • (1999) J. Immunol. , vol.163 , pp. 466-475
    • Akdis, M.1    Simon, H.U.2    Weigl, L.3    Kreyden, O.4    Blaser, K.5    Akdis, C.A.6
  • 30
    • 0034069636 scopus 로고    scopus 로고
    • Atopic dermatitis: New insights and opportunities for therapeutic investigation
    • Leung D.Y. Atopic dermatitis: new insights and opportunities for therapeutic investigation. J. Allergy Clin. Immunol. 105:2000;860-876.
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 860-876
    • Leung, D.Y.1
  • 31
    • 0035721724 scopus 로고    scopus 로고
    • Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells
    • Terui T., Sano K., Okada M., Shirota H., Honda M., Ozawa M., Hirasawa N., Tamura G., Tagami H. Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells. J. Invest. Dermatol. 117:2001;236-243.
    • (2001) J. Invest. Dermatol. , vol.117 , pp. 236-243
    • Terui, T.1    Sano, K.2    Okada, M.3    Shirota, H.4    Honda, M.5    Ozawa, M.6    Hirasawa, N.7    Tamura, G.8    Tagami, H.9
  • 32
    • 0029856251 scopus 로고    scopus 로고
    • Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis
    • Werfel T., Morita A., Grewe M., Renz H., Wahn U., Krutmann J., Kapp A. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107:1996;871-876.
    • (1996) J. Invest. Dermatol. , vol.107 , pp. 871-876
    • Werfel, T.1    Morita, A.2    Grewe, M.3    Renz, H.4    Wahn, U.5    Krutmann, J.6    Kapp, A.7
  • 33
    • 0028176866 scopus 로고
    • Lesional expression of interferon-gamma in atopic eczema
    • Grewe M., Gyufko K., Schopf E., Krutmann J. Lesional expression of interferon-gamma in atopic eczema. Lancet. 343:1994;25-26.
    • (1994) Lancet , vol.343 , pp. 25-26
    • Grewe, M.1    Gyufko, K.2    Schopf, E.3    Krutmann, J.4
  • 34
    • 0029098122 scopus 로고
    • Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients
    • Grewe M., Walther S., Gyufko K., Czech W., Schopf E., Krutmann J. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J. Invest. Dermatol. 105:1995;407-410.
    • (1995) J. Invest. Dermatol. , vol.105 , pp. 407-410
    • Grewe, M.1    Walther, S.2    Gyufko, K.3    Czech, W.4    Schopf, E.5    Krutmann, J.6
  • 35
    • 0035190595 scopus 로고    scopus 로고
    • Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cella from atopic dermatitis patients: Association between IL-13 and mite- specific IgE levels
    • Wakugawa M., Hayashi K., Nakamura K., Tamaki K. Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cella from atopic dermatitis patients: association between IL-13 and mite- specific IgE levels. J. Dermatol. Sci. 25:2001;116-126.
    • (2001) J. Dermatol. Sci. , vol.25 , pp. 116-126
    • Wakugawa, M.1    Hayashi, K.2    Nakamura, K.3    Tamaki, K.4
  • 36
    • 0036398967 scopus 로고    scopus 로고
    • Local but not systemic administration of IFNγ during the sensitization phase of protein antigen immunization suppress Th2 development in a murine model of atopic dermatitis
    • Wang L.-F., Wu J.-T., Sun C.-C. Local but not systemic administration of IFNγ during the sensitization phase of protein antigen immunization suppress Th2 development in a murine model of atopic dermatitis. Cytokaine. 19:2002;147-152.
    • (2002) Cytokaine , vol.19 , pp. 147-152
    • Wang, L.-F.1    Wu, J.-T.2    Sun, C.-C.3
  • 37
    • 0037083291 scopus 로고    scopus 로고
    • Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice
    • Yagi R., Nagai H., Iigo Y., Akimoto T., Arai T., Kubo M. Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. J. Immunol. 168:2002;2020-2027.
    • (2002) J. Immunol. , vol.168 , pp. 2020-2027
    • Yagi, R.1    Nagai, H.2    Iigo, Y.3    Akimoto, T.4    Arai, T.5    Kubo, M.6
  • 39
    • 0034746378 scopus 로고    scopus 로고
    • Intracellular 3′,5′-adenosine cyclic monophosphate level regulates house dust mite-induced Interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis
    • Kanda N., Watanabe S. Intracellular 3′,5′-adenosine cyclic monophosphate level regulates house dust mite-induced Interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis. J. Invest. Dermatol. 116:2001;3-11.
    • (2001) J. Invest. Dermatol. , vol.116 , pp. 3-11
    • Kanda, N.1    Watanabe, S.2
  • 40
    • 0028015581 scopus 로고
    • Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis
    • Hamid Q., Boguniewicz M., Leung D.Y.M. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J. Clin. Invest. 94:1994;870-876.
    • (1994) J. Clin. Invest. , vol.94 , pp. 870-876
    • Hamid, Q.1    Boguniewicz, M.2    Leung, D.Y.M.3
  • 41
    • 0029856251 scopus 로고    scopus 로고
    • Allergen specific of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis
    • Werfel T., Morita A., Grewe M., Renz H., Wahn U., Krutmann J., Kapp A. Allergen specific of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107:1996;871-876.
    • (1996) J. Invest. Dermatol. , vol.107 , pp. 871-876
    • Werfel, T.1    Morita, A.2    Grewe, M.3    Renz, H.4    Wahn, U.5    Krutmann, J.6    Kapp, A.7
  • 42
    • 0344211820 scopus 로고    scopus 로고
    • IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen
    • Herrick C.A., Xu L., McKenzie A.N.J., Tigelaar R.E., Bottomly K. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J. Immunol. 170:2003;2488-2495.
    • (2003) J. Immunol. , vol.170 , pp. 2488-2495
    • Herrick, C.A.1    Xu, L.2    McKenzie, A.N.J.3    Tigelaar, R.E.4    Bottomly, K.5
  • 43
    • 0026706275 scopus 로고
    • Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice
    • Wood L.C., Jackson S.M., Elias P.M., Grunfeld C., Feingold K.R. Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J. Clin. Invest. 90:1992;482-487.
    • (1992) J. Clin. Invest. , vol.90 , pp. 482-487
    • Wood, L.C.1    Jackson, S.M.2    Elias, P.M.3    Grunfeld, C.4    Feingold, K.R.5
  • 44
    • 0030748429 scopus 로고    scopus 로고
    • Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption
    • Nishijima T., Tokura Y., Imokawa G., Seo N., Furukawa F., Takigawa M. Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption. J. Invest. Dermatol. 109:1997;175-182.
    • (1997) J. Invest. Dermatol. , vol.109 , pp. 175-182
    • Nishijima, T.1    Tokura, Y.2    Imokawa, G.3    Seo, N.4    Furukawa, F.5    Takigawa, M.6
  • 46
    • 0026356495 scopus 로고
    • The spectrum of IgE-mediated responses to latex
    • Sussman G.L., Tario S., Dolovich J. The spectrum of IgE-mediated responses to latex. J. Am. Med. Assoc. 265:1991;2844-2847.
    • (1991) J. Am. Med. Assoc. , vol.265 , pp. 2844-2847
    • Sussman, G.L.1    Tario, S.2    Dolovich, J.3
  • 47
    • 0035141737 scopus 로고    scopus 로고
    • The spectrum of immunologic sensitization in latex allergy
    • Kurup V.P., Fink J.N. The spectrum of immunologic sensitization in latex allergy. Allergy. 56:2001;2-12.
    • (2001) Allergy , vol.56 , pp. 2-12
    • Kurup, V.P.1    Fink, J.N.2
  • 49
    • 0037237628 scopus 로고    scopus 로고
    • Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential Toll-like receptor ligation
    • Boonstra A., Asselin-Paturel C., Gilliet M., Crain C., Trinchieri G., Liu Y.J., Oarra A. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J. Exp. Med. 197:2003;101-109.
    • (2003) J. Exp. Med. , vol.197 , pp. 101-109
    • Boonstra, A.1    Asselin-Paturel, C.2    Gilliet, M.3    Crain, C.4    Trinchieri, G.5    Liu, Y.J.6    Oarra, A.7


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