A highly enantioselective benzothiepine synthesis

Journal of Organic Chemistry

Volumn 65, Issue 9, 2000, Pages 2711-2715

  Wang, Ching Cheng ^a   Li, James J ^a,b   Huang, Horng Chih ^a   Lee, Len F ^a   Reitz, David B ^a  

^a MONSANTO COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3 DIBUTYL 7 (DIMETHYLAMINO) 2,3,4,5 TETRAHYDRO 5 (4 METHOXYPHENYL) 1 BENZOTHIEPIN 4 OL 1,1 DIOXIDE; BENZOTHIEPINE; BILE ACID; OXAZIRIDINE DERIVATIVE; SULFOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HYPERCHOLESTEROLEMIA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THERMODYNAMICS; X RAY DIFFRACTION;

EID: 0034608007     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo991786q     Document Type: Article

References (24)

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22. The configuration of 1a was established from the X-ray structure of corresponding phenol.
23. Unpublished results.
24. Monte Carlo conformational search was performed on Macromodel 6.5 with MM3 force field and chloroform as the solvent. Energy calculation was performed on Sybyl 6.5 with Tripos force field and Gasteiger-Huckel charge method.