Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1- yl-benzonitrile as novel farnesyltransferase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 7, 2003, Pages 1293-1296

  Lin, Nan Horng ^a   Wang, Le ^a   Cohen, Jerry ^a   Gu, Wen Zhen ^a   Frost, David ^a   Zhang, Haiying ^a   Rosenberg, Saul ^a   Sham, Hing ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 BIPHENYL 2 YL 1 HYDROXY 1 (3 METHYL 3H IMIDAZOL 4 YL)PROP 2 YNYL] 1 YLBENZONITRILE; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MOUSE; NONHUMAN;

EID: 0037424686     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00122-7     Document Type: Article

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