6-Formylpterin protects retinal neurons from transient ischemia-reperfusion injury in rats: A morphological and immunohistochemical study

Neuropathology

Volumn 23, Issue 3, 2003, Pages 161-168

  Funakoshi, Taisaku ^a   Miyata, Hajime ^a   Imoto, Toshiaki ^a   Arai, Toshiyuki ^b   Endo, Nobuyuki ^c   Makino, Keisuke ^d   Yang, Chun Hui ^a   Ohama, Eisaku ^a,e  

^a TOTTORI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c WAKASA WAN ENERGY RESEARCH CENTER   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e TOTTORI UNIVERSITY   (Japan)

Author keywords

6 formylpterin; Neuroprotection; Rats; Retina; Transient ischemia reperfusion injury

Indexed keywords

PTERIN 6 ALDEHYDE; PTERIN DERIVATIVE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MALE; MORPHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA ISCHEMIA; RETINA NERVE CELL; THICKNESS;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; NEUROPROTECTIVE AGENTS; PTERINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINAL GANGLION CELLS; TIME FACTORS;

EID: 0141534401     PISSN: 09196544     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1789.2003.00493.x     Document Type: Article

References (35)

1. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982; 239: 57-69.
2. Selles-Navarro I, Villegas-Perez MP, Salvador-Silva M, Ruiz-Gomez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. A quantitative in vivo study. Invest Ophthalmol Vis Sci 1996; 37: 2002-2014.
3. Lam TT, Abler AS, Tso MO. Apoptosis and caspases after ischemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci 1999; 40: 967-975.
4. Netland PA, Chaturvedi N, Dreyer EB. Calcium channel blockers in the management of low-tension and open-angle glaucoma. Am J Ophthalmol 1993; 115: 608-613.
5. Osborne NN, DeSantis L, Bae JH et al. Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retina. Exp Eye Res 1999; 69: 331-342.
6. Siliprandi R, Canella R, Carmignoto G. Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia. Invest Ophthalmol Vis Sci 1993; 34: 3232-3245.
7. Unoki K, LaVail MM. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest Ophthalmol Vis Sci 1994; 35: 907-915.
8. Lagreze WA, Knorle R, Bach M, Feuerstein TJ. Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci 1998; 39: 1063-1066.
9. Lee MC, Chung YT, Lee JH, Jung JJ, Kim HS, Kim SU. Antioxidant effect of melatonin in human retinal neuron cultures. Exp Neurol 2001; 172: 407-415.
10. Peachey NS, Green DJ, Ripps H. Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye. Invest Ophthalmol Vis Sci 1993; 34: 58-65.
11. Dawson DA, Wadsworth G, Palmer AM. A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke. Brain Res 2001; 892: 344-350.
12. Windisch M, Gschanes A, Hutter-Paier B. Neurotrophic activities and therapeutic experience with a brain derived peptide preparation. J Neural Transm Suppl 1998; 53: 289-298.
13. Ishii K, Tomidokoro A, Nagahara M et al. Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans. Invest Ophthalmol Vis Sci 2001; 42: 2957-2963.
14. Mizuno K, Koide T, Saito N et al. Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys. Invest Ophthalmol Vis Sci 2002; 43: 3243-3250.
15. Watanabe K, Arai T, Mori H et al. Pterin-6-aldehyde, an inhibitor of xanthine oxidase, has superoxide anion radical scavenging activity. Biochem Biophys Res Commun 1997; 233: 447-450.
16. Oettl K, Reibnegger G. Pteridines as inhibitors of xanthine oxidase: structural requirements. Biochim Biophys Acta 1999; 1430: 387-395.
17. Mori H, Arai T, Ishii H et al. Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone. Neurosci Lett 1998; 241: 99-102.
18. Mori H, Arai T, Hirota K et al. Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 Macrophages. Biochim Biophys Acta 2000; 1474: 93-99.
19. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163.
20. Ishihara M, Nakano T, Ohama E, Kawai Y. Postischemic reperfusion in the eyes of young and aged rats. Jpn J Physiol 2000; 50: 125-132.
21. Katano H, Ishihara M, Shiraishi Y, Kawai Y. Effects of aging on the electroretinogram during ischemia-reperfusion in rats. Jpn J Physiol 2001; 51: 89-97.
22. Fox NE, van Kuijk FJ. Immunohistochemical localization of xanthine oxidase in human retina. Free Radic Biol Med 1998; 24: 900-905.
23. Kobayashi M, Kuroiwa T, Shimokawa R, Okeda R, Tokoro T. Nitric oxide synthase expression in ischemic rat retinas. Jpn J Ophthalmol 2000; 44: 235-244.
24. Koeberle PD, Ball AK. Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells. Exp Neurol 1999; 158: 366-381.
25. Arai T, Endo N, Yamashita K et al. 6-Formylpterin, a xanthine oxidase inhibitor, intracellularly generates reactive oxygen species involved in apoptosis and cell proliferation. Free Radic Biol Med 2001; 30: 248-259.
26. Yamashita K, Arai T, Fukuda K et al. 6-Formylpterin intracellularly generates hydrogen peroxide and restores the impaired bactericidal activity of human neutrophils. Biochem Biophys Res Commun 2001; 289: 85-90.
27. Hangai M, Miyamoto K, Hiroi K et al. Roles of constitutive nitric oxide synthase in postischemic rat retina. Invest Ophthalmol Vis Sci 1999; 40: 450-458.
28. Chiang SK, Lam TT. Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage. Invest Ophthalmol Vis Sci 2000; 41: 3210-3214.
29. Chun MH, Kim IB, Ju WK et al. Horizontal cells of the rat retina are resistant to degenerative processes induced by ischemia-reperfusion. Neurosci Lett 1999; 260: 125-128.
30. Shibuki H, Katai N, Kuroiwa S, Kurokawa T, Yodoi J, Yoshimura N. Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat. Invest Ophthalmol Vis Sci 1998; 39: 1470-1477.
31. Shibuki H, Katai N, Kuroiwa S et al. Expression and neuroprotective effect of hepatocyte growth factor in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 2002; 43: 528-536.
32. Ettaiche M, Fillacier K, Widmann C, Heurteaux C, Lazdunski M. Riluzole improves functional recovery after ischemia in the rat retina. Invest Ophthalmol Vis Sci 1999; 40: 729-736.
33. Watanabe I, Toyoda M, Okuda J et al. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: antibody against single-stranded DNA and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) methods. Jpn J Cancer Res 1999; 90: 188-193.
34. Maeda M, Sugiyama T, Akai F, Jikihara I, Hayashi Y, Takagi H. Single stranded DNA as an immunocytochemical marker for apoptotic change of ischemia in the gerbil hippocampus. Neurosci Lett 1998; 240: 69-72.
35. Naruse I, Keino H, Kawarada Y. Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis. Histochemistry 1994; 101: 73-78.