Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: A positron emission tomography study

Neuroscience

Volumn 121, Issue 2, 2003, Pages 479-486

  Umegaki, H ^a   Ishiwata, K ^b   Ogawa, O ^a   Ingram, D K ^c   Roth, G S ^c   Oda, K ^b   Kurotani, S ^a   Kawamura, K ^b   Wang, W F ^b   Ikari, H ^d   Senda, M ^b   Iguchi, A ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Aging; Autoradiography; Binding potential; Raclopride

Indexed keywords

ADENOVIRUS VECTOR; DOPAMINE 2 RECEPTOR; RACLOPRIDE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; CORPUS STRIATUM; EVALUATION; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; GENE TRANSFER; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

EID: 0141533142     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00489-5     Document Type: Article

References (35)

1. Choi-Lundberg D.L., Lin Q., Chang Y.N., Chiiang Y.L., Hay C.M., Mohajeri H., Davidson B.L., Bohn M.C. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science. 275:1997;838-841.
2. Byrnes A.P., Rusby J.E., Wood M.J., Charlton H.M. Adenovirus gene transfer causes inflammation in the brain. Neuroscience. 66:1995;1015-1024.
3. Davidson B.L., Allen E.D., Kozarsky K.F., Wilson J.M., Roessler B.J. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet. 3:1995;219-223.
4. Gould T.J., Stromberg I., Bickford P.C. Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats. Neurobiol Aging. 17:1996;877-883.
5. Hayakawa N., Uemura K., Ishiwata K., Shimada Y., Ogi N., Nagaoka T., Toyama H., Oda K., Tanaka A., Endo K., Senda M. A PET-MRI registration technique for PET studies of the rat brain. Nucl Med Biol. 27:2000;121-125.
6. Hume S.P., Lammertsma A.A., Myers R., Rajeswaran S., Bloomfield P.M., Ashworth S., Fricker R.A., Torres E.M., Watson I., Jones T. The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease. J Neurosci Methods. 67:1996;103-122.
7. Ikari H., Zhang L., Chernak J., Mastrangeli A., Kato S., Kuo H., Crystal R.G., Ingram D.K., Roth G.S. Adenovirus-mediated gene transfer of dopamine D2 receptor cDNA into rat striatum. Mol Brain Res. 34:1995;315-320.
8. Ingram D.K., Ikari H., Umegaki H., Chernak J.M., Roth G.S. Application of gene therapy to treat age-related loss of dopamine D2 receptor. Exp Gerontol. 33:1998;793-804.
9. 2 receptor. Mech Ageing Dev. 116:2000;77-93.
10. 11C]N-methylspiperone, in rats. Ann Nucl Med. 13:1999;161-167.
11. 11C]raclopride for routine use. Ann Nucl Med. 13:1999;195-197.
12. 11C]nemonapride . Nucl Med Biol. 26:1999;291-296.
13. Joseph J.A., Gupata M., Han Z., Roth G.S. The deleterious effects of aging and kainic acid may be selective for similar striatal neuronal populations. Aging. 3:1991;361-371.
14. Joseph J.A., Roth G.S. Upregulation of striatal dopamine receptors and improvement of motor performance in senescence. Ann NY Acad Sci. 515:1988;355-362.
15. Joseph J.A., Roth G.S. Hormonal regulation of motor behavior in senescence. J Gerontol Biol Sci. 48:1993;51-55.
16. Joseph J.A., Roth G.S., Strong R. The striatum, a microcosm for the examination of age-related alterations in the CNS: a selected review. Rothstein M. Review of biological research in aging. 1990;181-189 Alan R. Liss, New York.
17. Kyrkanides S., O'Banion M.K., Whiteley P.E., Daeschner J.C., Olschowka J.A. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol. 119:2001;269-277.
18. Lawrence M., Foellmer H., Elsworth J., Kim J., Leranth C., Kozlowski D., Bothwell A., Davidson B., Bohn M., Redmond D.R. Jr. Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus. Gene Ther. 6:1999;1368-1379.
19. Lesch K.P. Gene transfer to the brain emerging therapeutic strategy in psychiatry? Biol Psychiatry. 45:1999;247-253.
20. May T., Sugawa M. Altered dopamine receptor mediated signal transmission in the striatum of aged rats. Brain Res. 604:1993;106-111.
21. Merchant K.M., Dobie D.J., Dorsa D.M. Differential loss of dopamine D2 receptor mRNA isoforms during aging in Fischer-344 rats. Neurosci Lett. 154:1993;163-167.
22. Miller A.R. The aging immune system primer and prospectus . Science. 273:1996;70-74.
23. Missale C., Nash S.R., Robinson S.W., Jaber M., Caron M.G. Dopamine receptors from structure to function . Physiol Rev. 78:1998;189-225.
24. Morgan D.G., Finch C.E. Dopaminergic changes in the basal ganglia a generalized phenomenon of aging in mammals . Ann NY Acad Sci. 515:1988;145-160.
25. Mrak R.E., Griffin S.T., Graham D.I. Aging-associated changes in human brain. J Neuropathol Exp Neurol. 56:1997;1269-1275.
26. 2 receptors in rat striatum by positron emission tomography. Neuroreport. 11:2000;743-748.
27. Pawelec G., Solana R. Immunoscenescence. Immunol Today. 18:1997;514-516.
28. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1982;Academic Press, Sydney.
29. Suhr S.T., Gage F.H. Gene therapy for neurologic disease. Arch Neurol. 50:1993;1252-1268.
30. 2-like receptor binding in the F344/N rat striatum revealed by positron emission tomography and in vitro receptor autoradiography. Synapse. 41:2001;285-293.
31. Umegaki H., Chernak J.M., Ikari H., Roth G.S., Ingram D.K. Rotational behavior produced by adenovirus-mediated gene transfer of dopamine D2 receptor into rat striatum. Neuroreport. 8:1997;3553-3558.
32. 2 receptors in the rat striatum by positron emission tomography. Synapse. 43:2002;195-200.
33. Volkow N.D., Gur R.C., Wang G.J., Fowler J.S., Moberg P.J., Ding Y.S., Hitzemann R., Smith G., Logan J. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. Am J Psychiatry. 155:1998;344-349.
34. Watanabe M., Uchida H., Okada H., Shimizu K., Satoh N., Yoshikawa E., Ohmura T., Yamashita T., Tanaka E. A high resolution PET for animal studies. IEEE Trans Med Imag. 11:1992;577-580.
35. Zhang L., Ravipati A., Joseph J., Roth G.S. Aging-related changes in rat striatal D2 receptor mRNA-containing neurons a quantitative nonradioactive in situ hybridization study . J Neurosci. 153:1995;1735-1740.