Dynamic NMR structures of [Rp]- and [Sp]-phosphorothioated DNA-RNA hybrids: Is flexibility required for RNase H recognition?

Biophysical Journal

Volumn 85, Issue 4, 2003, Pages 2525-2538

  Tonelli, Marco ^a   Ulyanov, Nikolai B ^a   Billeci, Todd M ^a   Karwowski, Boleslaw ^b   Guga, Piotr ^b   Stec, Wojciech J ^b   James, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DEOXYRIBOSE; DNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; RIBONUCLEASE H; RNA; SODIUM ION;

ARTICLE; CALCULATION; COMPUTER SIMULATION; CONFORMATION; CRYSTAL STRUCTURE; DIELECTRIC CONSTANT; DNA RNA HYBRIDIZATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; SOLID; STRUCTURE ANALYSIS;

EID: 0141530960     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)74675-X     Document Type: Article

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