Antagonism of P2X3-containing channels: Commentary on Spelta et al.

British Journal of Pharmacology

Volumn 135, Issue 6, 2002, Pages 1343-1344

  Jarvis, Michael F ^a   Burgard, Edward C ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Competitive antagonism; Ligand association; TNP ATP

Indexed keywords

NF 279; PURINE P2X RECEPTOR; PURINE P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SURAMIN; TRINITROPHENYL; TRINITROPHENYL ADENOSINE TRIPHOSPHATE; UNCLASSIFIED DRUG; 2',3' O (2,4,6 TRINITRO CYCLOHEXADIENYLIDINE)ADENOSINE 5' TRIPHOSPHATE; 2',3'-O-(2,4,6-TRINITRO-CYCLOHEXADIENYLIDINE)ADENOSINE 5'-TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DRUG DERIVATIVE; PURINE P2 RECEPTOR;

DESENSITIZATION; DISSOCIATION; DRUG POTENCY; NOCICEPTION; NOTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; NOCICEPTIVE RECEPTOR; SENSORY NERVE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; NEURONS, AFFERENT; NOCICEPTORS; RECEPTORS, PURINERGIC P2;

EID: 0036009745     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704590     Document Type: Note

References (10)

1. Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine
2. Competitive antagonism of recombinant P2X(2/3) receptors by 2′, 3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)
3. P1 and P2 purine and pyrimidine receptor ligands
4. 3 homomeric and heteromeric channels in nociceptive signaling and behavior
5. Microscopic kinetics and energetics distinguish GABA(a) receptor agonists from antagonists
6. 1 receptors
7. 1 receptor
8. 2/3 heteromeric receptors
9. Pharmacological and electrophysiological properties of a chimeric human P2X2/P2X3 receptor
10. The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium