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Volumn 14, Issue 4, 2003, Pages 285-316

(Q)SARs: Gatekeepers against risk on chemicals?

Author keywords

(Q)SAR; Chemical legislation; DEREK; ECOSAR; Ecotoxicity; Human health

Indexed keywords

ANIMALS; COMPUTATIONAL CHEMISTRY; HEALTH RISKS; INDICATORS (CHEMICAL); LAWS AND LEGISLATION; RISK ASSESSMENT; TOXICITY;

EID: 0141462446     PISSN: 1062936X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1062936032000101510     Document Type: Article
Times cited : (54)

References (36)
  • 3
    • 0842271386 scopus 로고    scopus 로고
    • Ministry of Housing Spatial Planning and Environment, The Hague
    • SOMS (2001) Strategy on Management of Substances. Ministry of Housing Spatial Planning and Environment, The Hague. http://www2.minvrom.nl/Docs/ internationaal/soms_engels.pdf
    • (2001) Strategy on Management of Substances
  • 6
  • 10
    • 85195056024 scopus 로고    scopus 로고
    • ECOSAR (2002). http://www.epa.gov/oppt/newchems/21ecosar.htm
    • (2002)
  • 11
    • 85195026484 scopus 로고    scopus 로고
    • LHASA Limited, School of Chemistry, University of Leeds, UK
    • LHASA (2001). DEREKfW TM for windows version 5.0. LHASA Limited, School of Chemistry, University of Leeds, UK.
    • (2001) DEREKfW TM for Windows Version 5.0
  • 12
    • 0032619762 scopus 로고    scopus 로고
    • Knowledge-based expert systems for toxicity and metabolism prediction: DEREKfW, StAR and METEOR
    • Greene, H., Judson, H.N., Langowski, J.J. and Marchant, C.A. (1999) "Knowledge-based expert systems for toxicity and metabolism prediction: DEREKfW, StAR and METEOR", SAR QSAR Environ. Res. 10, 299-314.
    • (1999) SAR QSAR Environ. Res. , vol.10 , pp. 299-314
    • Greene, H.1    Judson, H.N.2    Langowski, J.J.3    Marchant, C.A.4
  • 13
    • 0025863682 scopus 로고
    • Computer prediction of possible toxic action from chemical structure; the DEREKfW system
    • Sanderson, D.M. and Earnshaw, C.G. (1991) "Computer prediction of possible toxic action from chemical structure; The DEREKfW system", Hum. Exp. Toxicol. 10, 261-273.
    • (1991) Hum. Exp. Toxicol. , vol.10 , pp. 261-273
    • Sanderson, D.M.1    Earnshaw, C.G.2
  • 15
    • 0036319482 scopus 로고    scopus 로고
    • Comparison of the computer programs DEREK and TOPKAT to predict bacterial mutagenicity
    • Cariello, N.D., Wilson, J.D., Britt, B.H., Wedd, D.J., Burlinson, B. and Gombar, V. (2002) "Comparison of the computer programs DEREK and TOPKAT to predict bacterial mutagenicity", Mutagenesis 17, 321-329.
    • (2002) Mutagenesis , vol.17 , pp. 321-329
    • Cariello, N.D.1    Wilson, J.D.2    Britt, B.H.3    Wedd, D.J.4    Burlinson, B.5    Gombar, V.6
  • 16
    • 0142038383 scopus 로고    scopus 로고
    • Implementation of QSARs in ecotoxicological risk assessment
    • Bilthoven, The Netherlands
    • Posthumus, R. and Slooff, W. (2001). Implementation of QSARs in ecotoxicological risk assessment, RIVM report 601516 003, Bilthoven, The Netherlands.
    • (2001) RIVM Report 601516 003
    • Posthumus, R.1    Slooff, W.2
  • 18
    • 0026785215 scopus 로고
    • Classifying environmental pollutants. Structure-activity relationships for predicting aquatic toxicity
    • Verhaar, H.J.M., van Leeuwen, C.J. and Hermens, J.L.M. (1992) "Classifying environmental pollutants. Structure-activity relationships for predicting aquatic toxicity", Chemosphere 25, 471-491.
    • (1992) Chemosphere , vol.25 , pp. 471-491
    • Verhaar, H.J.M.1    Van Leeuwen, C.J.2    Hermens, J.L.M.3
  • 21
    • 0036001299 scopus 로고    scopus 로고
    • A framework for prioritizing fragrance materials for aquatic risk assessment
    • Salvito, D.T., Senna, R.J. and Federle, T.W. (2002) "A framework for prioritizing fragrance materials for aquatic risk assessment", Environ. Toxicol. Chem. 21, 1301-1308.
    • (2002) Environ. Toxicol. Chem. , vol.21 , pp. 1301-1308
    • Salvito, D.T.1    Senna, R.J.2    Federle, T.W.3
  • 23
    • 9644264920 scopus 로고    scopus 로고
    • The evaluation and classification of substances with a defatting action on the skin
    • Working group on Defatting substances, Stockholm, ECB/22/96-Add.10
    • Boman, A. (1996). The evaluation and classification of substances with a defatting action on the skin. Ad-hoc Working group on Defatting substances, Stockholm, ECB/22/96-Add. 10.
    • (1996) Ad-hoc
    • Boman, A.1
  • 24
    • 0142038382 scopus 로고
    • Appendix A: Quantitative structure activity relationships for skin corrosivity
    • Barratt, M. (1995) "Appendix A: quantitative structure activity relationships for skin corrosivity", ATLA 23, 219-255.
    • (1995) ATLA , vol.23 , pp. 219-255
    • Barratt, M.1
  • 25
    • 0029887895 scopus 로고    scopus 로고
    • QSARs for skin corrosivity of organic acids, bases and phenols: Principal components and neural network analysis of extended datasets
    • Barratt, M.D. (1996) "QSARs for skin corrosivity of organic acids, bases and phenols: principal components and neural network analysis of extended datasets", Toxicol. In Vitro 10, 85-94.
    • (1996) Toxicol. In Vitro , vol.10 , pp. 85-94
    • Barratt, M.D.1
  • 26
    • 0031819724 scopus 로고    scopus 로고
    • The ECVAM International validation study on in vitro tests for skin corrosivity. I. Selection and distribution of the test chemicals
    • Barratt, M.D., Brantom, P.G., Fentem, J.H., Gerner, I., Walker, A.P. and Worth, A.P. (1998) "The ECVAM International validation study on In Vitro Tests for Skin Corrosivity. I. Selection and distribution of the test chemicals", Toxicol. In vitro 12, 471-482.
    • (1998) Toxicol. In Vitro , vol.12 , pp. 471-482
    • Barratt, M.D.1    Brantom, P.G.2    Fentem, J.H.3    Gerner, I.4    Walker, A.P.5    Worth, A.P.6
  • 27
    • 0038101436 scopus 로고    scopus 로고
    • Structure-activity rules for skin and eye irritation and corrosion
    • Payne, M.P. and Morley, J. (1997) "Structure-activity rules for skin and eye irritation and corrosion", Hum. Exp. Toxicol. 16, 410.
    • (1997) Hum. Exp. Toxicol. , vol.16 , pp. 410
    • Payne, M.P.1    Morley, J.2
  • 28
    • 0026355090 scopus 로고
    • Chemical selection by the TSCA Interagency Testing Committee: Use of computerized substructure searching to identify chemical groups for health effects, chemical fate and ecological effects testing
    • Walker, J.D. (1991) "Chemical selection by the TSCA Interagency Testing Committee: use of computerized substructure searching to identify chemical groups for health effects, chemical fate and ecological effects testing", Sci. Total Environ. 109/110, 691-700.
    • (1991) Sci. Total Environ. , vol.109-110 , pp. 691-700
    • Walker, J.D.1
  • 29
    • 0029535029 scopus 로고
    • Estimation methods used by the TSCA Interagency Testing Committee to prioritize chemicals for testing: Exposure and biological effects scoring and structure
    • Walker, J.D. (1995) "Estimation methods used by the TSCA Interagency Testing Committee to Prioritize Chemicals for Testing: Exposure and Biological effects scoring and structure", Toxicol. Modelling 1, 123-141.
    • (1995) Toxicol. Modelling , vol.1 , pp. 123-141
    • Walker, J.D.1
  • 30
    • 0033739877 scopus 로고    scopus 로고
    • Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system
    • Gerner, I., Zinke, S., Graetschel, G. and Schlede, E. (2000) "Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system", ATLA 28, 665-698.
    • (2000) ATLA , vol.28 , pp. 665-698
    • Gerner, I.1    Zinke, S.2    Graetschel, G.3    Schlede, E.4
  • 31
    • 0033091308 scopus 로고    scopus 로고
    • Validation and subsequent development of the Derek skin sensitisation rulebase by analysis of the BgVV list of contact allergens
    • Barratt, M.D. and Langowski, J.J. (1999) "Validation and subsequent development of the Derek skin sensitisation rulebase by analysis of the BgVV list of contact allergens", J. Chem. Inf. Comput. Sci. 39, 294-298.
    • (1999) J. Chem. Inf. Comput. Sci. , vol.39 , pp. 294-298
    • Barratt, M.D.1    Langowski, J.J.2
  • 32
    • 0036323878 scopus 로고    scopus 로고
    • Evaluation of a role base for identifying contact allergens by using a regulatory database: Comparison of data on chemicals notified in the European Union with 'structural alerts' used in the DEREK Expert System
    • Zinke, S., Gerner, I. and Schlede, E. (2002) "Evaluation of a role base for identifying contact allergens by using a regulatory database: comparison of data on chemicals notified in the European Union with 'structural alerts' used in the DEREK Expert System", ATLA 30, 285-298.
    • (2002) ATLA , vol.30 , pp. 285-298
    • Zinke, S.1    Gerner, I.2    Schlede, E.3
  • 33
    • 0028054706 scopus 로고
    • Detecting and predicting the activity of rodent carcinogens
    • Parry, J.M. (1994) "Detecting and predicting the activity of rodent carcinogens", Mutagenesis 9, 3-5.
    • (1994) Mutagenesis , vol.9 , pp. 3-5
    • Parry, J.M.1
  • 34
    • 0036491315 scopus 로고    scopus 로고
    • AI and SAR approaches for predicting chemical carcinogenicity: Survey and status report
    • Richard, A.M. and Benignini, R. (2002) "AI and SAR approaches for predicting chemical carcinogenicity: survey and status report", SAR QSAR Environ. Res. 13, 1-19.
    • (2002) SAR QSAR Environ. Res. , vol.13 , pp. 1-19
    • Richard, A.M.1    Benignini, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.