Loss of nectin-2 at sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration

Biology of Reproduction

Volumn 69, Issue 4, 2003, Pages 1330-1340

  Mueller, Steffen ^a   Rosenquist, Thomas A ^b   Takai, Yoshimi ^c   Bronson, Richard A ^a   Wimmer, Eckard ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fertilization; Sertoli cells; Sperm; Spermatid; Spermatogenesis

Indexed keywords

CELL ADHESION MOLECULE; ESPIN; IMMUNOGLOBULIN; NECTIN 2; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CD155 GENE; CELL FUSION; CELL JUNCTION; CELL LINE; CONTROLLED STUDY; EPIDIDYMIS; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; HAMSTER; KNOCKIN GENE; KNOCKOUT GENE; MALE; MALE INFERTILITY; MOUSE; NECTIN 2 LACZ LACZ GENE; NECTIN 3 GENE; NECTIN GENE; NONHUMAN; OOCYTE; OOCYTE PENETRATION; OVIDUCT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; SERTOLI CELL; SPERMATID; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON MIGRATION; SPERMATOZOON MOTILITY; TESTIS; ZONA PELLUCIDA;

ANIMALS; CELL ADHESION MOLECULES; EPIDIDYMIS; FEMALE; GENETIC ENGINEERING; INFERTILITY, MALE; INTERCELLULAR JUNCTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; OOCYTES; SERTOLI CELLS; SPERM MOTILITY; SPERM-OVUM INTERACTIONS; SPERMATIDS; SPERMATOZOA; ZONA PELLUCIDA;

ANIMALIA; CRICETINAE;

EID: 0141460514     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.102.014670     Document Type: Article

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