Ah receptor regulation of mouse Cyp1B1 is additionally modulated by a second novel complex that forms at two AhR response elements

Toxicology and Applied Pharmacology

Volumn 192, Issue 2, 2003, Pages 174-190

  Zhang, Leying ^a   Zheng, Wenchao ^a   Jefcoate, Colin R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Ah receptor; Cyp1A1; Cyp1B1; Promoter; TCDD; XRE

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1B1; LUCIFERASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; DNA TRANSCRIPTION; EMBRYO; ENHANCER REGION; FIBROBLAST; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE CONTROL; GENE MUTATION; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0141459483     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00276-X     Document Type: Article

References (43)

1. Alexander D.L., Zhang L., Foroozesh M., Alworth W.L., Jefcoate C.R. Metabolism-based polycyclic aromatic acetylene inhibition of Cyp1B1 in C3H10T1/ 2 cells potentiates aryl hydrocarbon receptor activity. Toxicol. Appl. Pharmacol. 161:1999;123-139.
2. Asman D.C., Takimoto K., Pitot H.C., Dunn T.J., Lindahl R. Organization and characterization of the rat class 3 aldehyde dehydrogenase gene. J. Biol. Chem. 268:1993;12530-12536.
3. Baba T., Mimura J., Gradin K., Kuroiwa A., Watanabe T., Matsuda Y., Inazawa J., Sogawa K., Fujii-Kuriyama Y. Structure and expression of the Ah receptor repressor gene. J. Biol. Chem. 276:2001;33101-33110.
4. Bhattacharyya K.K., Brake P.B., Eltom S.E., Otto S.A., Jefcoate C.R. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat Cyp1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J. Biol. Chem. 270:1995;11595-11602.
5. Brake P.B., Jefcoate C.R. Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3′,5′-monophosphate and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology. 136:1995;5034-5041.
6. Christou M., Mitchell M.J., Aoyama T., Gelboin H.V., Gonzalez F.J., Jefcoate C.R. Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane modification of this effect by specific amino acid substitutions . Biochemistry. 31:1992;2835-2841.
7. Dolwick K.M., Swanson H.I., Bradfield C.A. In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Proc. Natl. Acad. Sci. USA. 90:1993;8566-8570.
8. Dong L., Ma Q., Whitlock J.P. Jr. DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced Cyp1A1 transcription in vivo. J. Biol. Chem. 271:1996;7942-7948.
9. Elferink C.J., Gasiewicz T.A., Whitlock J.P. Jr. Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric. J. Biol. Chem. 265:1990;20708-20712.
10. Eltom S., Zhang L., Jefcoate C.R. Regulation of cytochrome P-450 (CYP) 1B1 in mouse Hepa-1c1c7 variant cell lines a possible role for aryl hydrocarbon receptor nuclear translocator (ARNT) as a suppressor of Cyp1B1 gene expression . Mol. Pharmacol. 55:1999;594-604.
11. Emi Y., Ikushiro S., Iyanagi T. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J. Biol. Chem. 271:1996;3952-3958.
12. Gonzalez F.J. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:1988;243-288.
13. Heidel S.M., Czuprynski C.J., Jefcoate C.R. Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene. Mol. Pharmacol. 54:1998;1000-1006.
14. Hoffman E.C., Reyes H., Chu F.-F., Sander F., Conley L.H., Brooks B.A., Hankinson O. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science. 252:1991;954-958.
15. Holmes J.L., Pollenz R.S. Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines development of quantitative Western blotting protocols for calculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates . Mol. Pharmacol. 52:1997;202-211.
16. Imataka H., Nakayama K., Yasumoto K., Mizuno A., Fujii-Kuriyama Y., Hayami M. Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5′-ultranslated region. J. Biol. Chem. 269:1994;20668-20673.
17. Imataka H., Sogawa K., Yasumoto K., Kobayashi A., Hayami M., Fujii-Kuriyama Y. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 11:1992;3663-3671.
18. Kawajiri K., Gotoh O., Tagashira Y., Sogawa K., Fuji-Kuriyama Y. Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver. Proc. Natl. Acad. Sci. USA. 81:1984;1649-1653.
19. Ko H.P., Okino S.T., Ma Q., Whitlock J.P. Jr. Dioxin-induced Cyp1A1 transcription in vivo the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure . Mol. Cell. Biol. 16:1996;430-436.
20. Kobayashi A., Sogawa K., Fujii-Kuriyama Y. Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of Cyp1A1 gene. J. Biol. Chem. 271:1996;12310-12316.
21. Larsen M.C., Angus W.G., Brake P.B., Eltom S.E., Sukow K.A., Jefcoate C.R. Characterization of Cyp1B1 and Cyp1A1 expression in human mammary epithelial cells role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism . Cancer Res. 58:1998;2366-2374.
22. Li H., Dong L., Whitlock J.P. Jr. Transcriptional activation function of the mouse Ah receptor nuclear translocator. J. Biol. Chem. 269:1994;28098-28105.
23. Lusska A., Shen E., Whitlock J.P. Jr. Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor. J. Biol. Chem. 268:1993;6575-6580.
24. Murray G.I. The role of cytochrome P450 in tumour development and progression and its potential in therapy. [Review] [67 refs]. J. Pathol. 192:2000;419-426.
25. Nelson D.R., Kamataki T., Waxman D.J., Guengerich F.P., Estabrook R.W., Feyereisen R., Gonzalez F.J., Coon M.J., Gunsalus I.C., Gotoh O. The P450 superfamily update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. [Review] [605 refs] . DNA Cell Biol. 12:1993;1-51.
26. Otto S.A., Bhattacharyya K.K., Jefcoate C.R. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). Endocrinology. 131:1992;3067-3076.
27. Pollenz R.S., Sattler C.A., Poland A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol. 45:1994;428-438.
28. Reyes H., Reisz-Porszasz S., Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science. 256:1992;1193-1195.
29. Robertson R.W., Zhang L., Pasco D.S., Fagan J.B. Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence - a multicomponent mechanism for activation of cytochrome P4501A1 (Cyp1A1) gene transcription. Nucleic Acids Res. 22:1994;1741-1749.
30. Savas Ü., Bhattacharyya K.K., Christou M., Alexander D.L., Jefcoate C.R. Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. J. Biol. Chem. 269:1994;14905-14911.
31. Shehin S.E., Stephenson R.O., Greenlee W.F. Transcriptional regulation of the human Cyp1B1 gene. Evidence for involvement of an aryl hydrocarbon receptor response element in constitutive expression. J. Biol. Chem. 275:2000;6770-6776.
32. Shen Z., Liu J., Wells R.L., Elkind M.M. DNA. Cell Biol. 13:1994;763-769.
33. Shen Z., Wells R.L., Liu J., Elkind M.M. Identification of a cytochrome P450 gene by reverse transcription - PCR using degenerate primers containing inosine. Proc. Natl. Acad. Sci. USA. 90:1993;11483-11487.
34. Sutter T.R., Tang Y.M., Hayes C.L., Wo Y.-Y.P., Jabs E.W., Li X., Yin H., Cody C.W., Greenlee W.F. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem. 269:1994;13092-13099.
35. Swanson H.I., Bradfield C.A. The AH-receptor genetics, structure and function. [Review] [115 refs] . Pharmacogenetics. 3:1993;213-230.
36. Swanson H.I., Chan W.K., Bradfield C.A. DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J. Biol. Chem. 270:1995;26292-26302.
37. Takahashi Y., Nakayama K., Itoh S., Fuji-Kuriyama Y., Kamataki T. Inhibition of the transcription of Cyp1A1 gene by the upstream stimulatory factor 1 in rabbits. Competitive binding of USF1 with AhR-Arnt complex. J. Biol. Chem. 272:1997;30025-30031.
38. Tang Y.M., Wo Y.-Y.P., Stewart J., Hawkins A.L., Griffin C.A., Sutter T.R., Greenlee W.F. Isolation and characterization of the human cytochrome P450 Cyp1B1 gene. J. Biol. Chem. 271:1996;28324-28330.
39. Wen L.-P., Koeiman N., Whitlock J.P. Jr. Dioxin-inducible, Ah receptor-dependent transcription in vitro. Proc. Natl. Acad. Sci. USA. 87:1990;8545-8549.
40. Wo Y.-Y.P., Stewar J., Greenlee W.F. Functional analysis of the promoter for the human Cyp1B1 gene. J. Biol. Chem. 272:1997;26702-26707.
41. Zhang L., Savas U., Alexander D.L., Jefcoate C.R. Characterization of the mouse Cyp1B1 gene. Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression. J. Biol. Chem. 273:1998;5174-5183.
42. Zhang W., Shields J.M., Sogawa K., Fujii-Kuriyama Y., Yang V.W. The gut-enriched Kruppel-like factor suppresses the activity of the Cyp1A1 promoter in an Spl-dependent fashion. J. Biol. Chem. 273:1998;17917-17925.
43. Zheng W., Brake P.B., Bhattacharyya K.K., Zhang L., Zhao D., Jefcoate C.R. Cell selective cAMP induction of rat CYP1B1 in adrenal and testis cells. Identification of novel cAMP-responsive for upstream enhancer and a second Ah receptor-dependent mechanism. Arch. Biochem. Biophys. 416:2003;53-67.