Kinetics of degradation of 4-imidazolidinone prodrug types obtained from reacting prilocaine with formaldehyde and acetaldehyde

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 2, 2003, Pages 233-240

  Larsen, Susan Weng ^a   Sidenius, Martin ^a   Ankersen, Michael ^b   Larsen, Claus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

4 Imidazolidinones; Cyclic N Mannich base; Isomeric form; Kinetics of decomposition; Prilocaine; Prodrugs

Indexed keywords

DEGRADATION; FORMALDEHYDE; HYDROLYSIS; KETONES; PH EFFECTS; REACTION KINETICS;

BUFFER SOLUTIONS;

DRUG PRODUCTS;

4 IMIDAZOLIDINONE; ACETALDEHYDE; FORMALDEHYDE; MANNICH BASE; PRILOCAINE; PRODRUG; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; DIASTEREOISOMER; DRUG ACTIVATION; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG MONITORING; EQUILIBRIUM CONSTANT; HALF LIFE TIME; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PHYSIOLOGY; PRIORITY JOURNAL;

EID: 0141447807     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00198-2     Document Type: Article

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