Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201

Antiviral Research

Volumn 52, Issue 3, 2001, Pages 251-259

  Smee, Donald F ^a   Sidwell, Robert W ^a   Morrison, Ann C ^a   Bailey, Kevin W ^a   Baum, Ellen Z ^b   Ly, Linh ^b   Wagaman, Pamela C ^b  

^a UTAH STATE UNIVERSITY   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Antiviral; Drug resistance; Influenza virus; Neuraminidase inhibitor

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; CYCLOPENTANE SIALIDASE INHIBITOR; GLUTAMIC ACID; HEMAGGLUTININ; LYSINE; OSELTAMIVIR; PERAMIVIR; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; CYTOPATHOGENIC EFFECT; DRUG SENSITIVITY; INFLUENZA VIRUS A; INFLUENZA VIRUS B; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; VIRUS CHARACTERIZATION; VIRUS INHIBITION; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL LINE, TRANSFORMED; CYCLOPENTANES; DOGS; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; GUANIDINES; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MUTATION; NEURAMINIDASE; VIRULENCE;

EID: 0034773748     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00168-1     Document Type: Article

References (18)

1. BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
2. Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
3. Biochemical methods for the characterization of influenza viruses with reduced sensitivity to 4-guanidino-Neu5Ac2en
4. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en
5. Phenotypic and genotypic assay of influenza neuraminidase indicates a low incidence of viral drug resistance during treatment with oseltamivir
6. Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus
7. Safety and efficacy of an oral neuraminidase inhibitor RWJ-270201 in treating experimental influenza A and B in healthy adult volunteers
8. Gene structure and replication of influenza virus
9. Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en
10. Resistance of influenza viruses to neuraminidase inhibitors - A review
11. Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection
12. A simple method of estimating fifty percent end points
13. Use of disposable micro tissue culture plates in antiviral and interferon induction studies
14. Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice
15. In vivo influenza-inhibitory effects of the cyclopentane neuraminidase inhibitor RWJ-270201
16. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities
17. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
18. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid