Overexpression of NSAID-activated gene product in prostate cancer

International Journal of Surgical Pathology

Volumn 11, Issue 3, 2003, Pages 159-166

  Iczkowski, Kenneth A ^a,b   Pantazis, Cooley G ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Immunohistochemistry; NAG 1; Prostate cancer; Prostatic intraepithelial neoplasia; PTGF

Indexed keywords

GENE PRODUCT; POLYCLONAL ANTIBODY; PROSTATE SPECIFIC ANTIGEN; PROTEIN NAG 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOPSY; CANCER GRADING; CANCER TISSUE; COMORBIDITY; CONTROLLED STUDY; CYTOPLASM; DNA MICROARRAY; ENUCLEATION; EPITHELIUM; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATECTOMY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; TRANSURETHRAL RESECTION; WESTERN BLOTTING;

EID: 0043246661     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/106689690301100302     Document Type: Article

References (25)

1. Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, Moskaluk CA, Frierson HF, Hampton GM. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 61:5974-5978, 2001
2. Lawton LN, Bonaldo MF, Jelenc PC, Qiu L, Baumes SA, Marcelino RA, Jesus GM, Wellington S, Knowles JA, Warburton D, Brown S, Soares MB. Identification of a novel member of the TGF-beta family highly expressed in human placenta. Gene 203:17-26, 1997
3. Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, He XY, Zhang HP, Donnellan M, Mahler S, Pryor K, Walsh BJ, Nicholson RC, Fairlie WD, Por SB, Rubbins JM, Breit SN. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily. Proc Natl Acad Sci USA 94:11514-11519, 1997
4. Baek SJ, Kim K-S, Nixon JB, Wilson LC, Eling TE. Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol 59:901-908, 2001
5. Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, Ke HZ, Qi H, Owen TA, Thompson DD. Cloning and characterization of a novel member of the transforming growth factor-β/bone morphogenetic protein family. J Biol Chem 273:13760-13767, 1998
6. Chan TY, Partin AW, Walsh PC, Epstein JI. Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy. Urology 56:823-827, 2000
7. Sakr WA, Tefilli MV, Grignon DJ, Banerjee M, Dey J, Gheiler EL, Tiguert R, Powell IJ, Wood DP. Gleason score 7 prostate cancer: A heterogeneous entity? Correlation with pathologic parameters and disease-free survival. Urology 56:730-734, 2000
8. Sobin LH, Wittekind C (eds). TNM classification of malignant tumors. 5th ed. Wiley-Liss, New York, pp. 170-173, 1997
9. Li PX, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C, Austin RC, Klamut HJ. Placental TGF-β is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J Biol Chem 275:20127-20135, 2000
10. Tan M, Wang Y, Guan K, Sun Y. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci USA 97:109-114, 2000
11. Shi Y, Simmons MN, Seki T, Oh SP, Sugrue SP. Change in gene expression subsequent to induction of PNN/DRS/memA: Increase in p21 cip1/waf1. Oncogene 20:4007-4018, 2001
12. Sommerfeld H-J, Meeker AK, Piatyszek MA, Bova GS, Shay JW, Coffey DS. Telomerase activity: A prevalent marker of malignant human prostate tissue. Cancer Res 56:218-222, 1996
13. Iczkowski KA, Pantazis CG, McGregor D, Wu Y, Tawfik OW. Telomerase subunit hTERT immunoreactivity: A marker for high-grade prostate cancer. Cancer 95:2487-2493, 2002
14. Ramnani DM, Bostwick DG, deMarzo AM. Basal cell-specific anti-keratin antibody 34βE12: Optimizing its use in distinguishing benign prostate and cancer [editorial]. Mod Pathol 12:443-444, 1999
15. Abrahams N, Ormsby A, Brainard J. Cytokeratin 5/6 is a basal cell-specific marker in benign prostatic glandular proliferations and in prostate tissue with androgen deprivation effect. Mod Pathol 15:150A, 2002
16. Parsons JK, Gage WR, Nelson WG. p63 protein is rare in prostate adenocarcinoma; implications for cancer diagnosis and carcinogenesis. Urology 58:619-624, 2001
17. Cohen RJ, Beales MP, McNeal JE. Prostate secretory granules in normal and neoplastic prostate glands: A diagnostic aid to needle biopsy. Hum Pathol 31:1515-1519, 2000
18. Beach R, Gown AM, Folpe AL. Immunohistochemical expression of P540S gene protein in 367 18-gauge prostatic needle biopsies: Potential adjunctive marker for the diagnosis of adenocarcinoma. Mod Pathol 15:155A, 2002
19. Luo J, Gage WR, Hick JL. Overexpression of alpha methyl acyl-CoA racemase in prostate cancer analyzed by cDNA microarrays and high density tissue microarrays. Mod Pathol 15:171A, 2002
20. Jiang Z, Woda BA, Yang XJ. Alpha-methylacyl coenzyme A racemase as a marker for prostate cancer. JAMA 287:3080-3081, 2002
21. Shah R, Mucci NR, Amin A, Macoska JA, Rubin MA. Postatrophic hyperplasia of the prostate: Neoplastic precursor or innocent bystander? Am J Pathol 158:1767-1773, 2001
22. Nieburgs HE, Zak RG, Allen DC, Reisman H, Clardy T. Systemic cellular changes in material from human and animal tissues in presence of tumors. In: Transactions of the Seventh Annual Meeting of the Inter-Society Cytology Council, pp. 137-144, 1959
23. Mairinger T, Mikuz G, Gschwendtner A. Nuclear chromatin texture analysis of nonmalignant tissue can detect adjacent prostatic adenocarcinoma. Prostate 41:12-19, 1999
24. Moore AG, Brown DA, Fairlie WD, Bauskin MW, Brown PK, Munier ML, Russell PK, Salamonsen LA, Wallace EM, Breit SN. The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J Clin Endocrinol Metab 85:4781-4788, 2000
25. 1 strongly predict clinical outcome in patients with bladder carcinoma. Cancer 92:2985-2992, 2001