Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens

Journal of Medicinal Chemistry

Volumn 46, Issue 17, 2003, Pages 3655-3661

  Hu, X Eric ^a   Kim, Nick K ^a   Gray, Jeffrey L ^a   Almstead, Ji In K ^a   Seibel, William L ^a   Ledoussal, Benoit ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 ETHYLPIPERIDINYLQUINOLONE DERIVATIVE; ANTIINFECTIVE AGENT; BALOFLOXACIN; CIPROFLOXACIN; CLINAFLOXACIN; GATIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; PIPERAZINE DERIVATIVE; PREMAFLOXACIN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIA; DNA GYRASE; DNA, SUPERHELICAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; QUINOLONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0043234175     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030272n     Document Type: Article

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