Effects of the synthetic cannabinoid nabilone on spatial learning and hippocampal neurotransmission

Pharmacology Biochemistry and Behavior

Volumn 75, Issue 3, 2003, Pages 585-591

  Diana, Giovanni ^a   Malloni, Massimiliano ^a   Pieri, Massimo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cannabinoids; Learning; Long term depression; Long term potentiation; Nabilone; Rat; Water maze

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; DELTA8 TETRAHYDROCANNABINOL; GLUTAMIC ACID; NABILONE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DOSE RESPONSE; FACILITATION; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; SYNAPTIC INHIBITION;

CANNABIS SATIVA;

EID: 0043199789     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(03)00127-8     Document Type: Article

References (41)

1. Ahmedzai S., Carlyle D.L., Calder I.T., Moran F. Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. Br. J. Cancer. 48:1983;657-663.
2. Ameri A., Wilhelm A., Simmet T. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. Br. J. Pharmacol. 126:1999;1831-1839.
3. Arolfo M.P., Brioni J.D. Diazepam impairs place learning in the Morris water maze. Behav. Neural. Biol. 55:1991;131-136.
4. Barinaga M. Neurobiology. How cannabinoids work in the brain. Science. 291:2001;2530-2531.
5. Breivogel C.S., Griffin G., Di Marzo V., Martin B.R. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol. Pharmacol. 60:2001;155-163.
6. Browne R.G., Weissman A. Discriminative stimulus properties of delta 9-tetrahydrocannabinol: mechanistic studies. J. Clin. Pharmacol. 21:1981;227S-234S.
7. Collins D.R., Pertwee R.G., Davies S.N. The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice. Eur. J. Pharmacol. 259:1994;R7-R8.
8. Da S., Takahashi R.N. SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry. 26:2002;321-325.
9. Diana G. Delta-8 and delta-9 tetrahydrocannabinol affect spatial learning in the Morris water maze test in rats. Neurosci. Lett. 1992;S39.
10. Diana G., Pieri M., Valentini G. Effects of Win 55,212-2 on hippocampal CA1 long-term potentiation in experiments controlled for basal glutamatergic synaptic transmission. Eur. J. Pharmacol. 453:2002;251-254.
11. Gilbert P.E. A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J. Clin. Pharmacol. 21:1981;311S-319S.
12. Glass R.M., Uhlenhuth E.H., Hartel F.W., Schuster C.R., Fischman M.W. A single dose study of nabilone, a synthetic cannabinoid. Psychopharmacology (Berl). 71:1980;137-142.
13. Glass R.M., Uhlenhuth E.H., Hartel F.W., Schuster C.R., Fischman M.W. Single-dose study of nabilone in anxious volunteers. J. Clin. Pharmacol. 21:1981;383S-396S.
14. Gong H., Tashkin D.P., Calvarese B. Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects. J. Clin. Pharmacol. 23:1983;127-133.
15. Hajos N., Ledent C., Freund T.F. Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience. 106:2001;1-4.
16. Hamann W., di Vadi P.P. Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors. [letter] Lancet. 353:1999;560.
17. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11:1991;563-583.
18. Herman T.S., Einhorn L.H., Jones S.E., Nagy C., Chester A.B., Dean J.C.et al. Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N. Engl. J. Med. 300:1979;1295-1297.
19. Johansson R., Kilkku P., Groenroos M. A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy. Cancer Treat. Rev. 9(Suppl. B):1982;25-33.
20. Johnson R., Jasinski D. Abuse potential of nabilone. 2nd World Conference on Clinical Pharmacology and Therapeutics, Washington, DC. 1983;90.
21. Kemp N., McQueen J., Faulkes S., Bashir Z.I. Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol. Eur. J. Neurosci. 12:2000;360-366.
22. Levenes C., Daniel H., Soubrie P., Crepel F. Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells. J. Physiol. (Lond.). 510:1998;867-879.
23. London S.W., McCarthy L.E., Borison H.L. Suppression of cancer chemotherapy-induced vomiting in the cat by nabilone, a synthetic cannabinoid. Proc. Soc. Exp. Biol. Med. 160:1979;437-440.
24. McCarthy L.E., Borison H.L. Antiemetic activity of N-methyllevonantradol and nabilone in cisplatin-treated cats. J. Clin. Pharmacol. 21:1981;30S-37S.
25. Misner D.L., Sullivan J.M. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. J. Neurosci. 19:1999;6795-6805.
26. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 11:1984;47-60.
27. Nowicky A.V., Teyler T.J., Vardaris R.M. The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro. Brain Res. Bull. 19:1987;663-672.
28. Onaivi E.S., Green M.R., Martin B.R. Pharmacological characterization of cannabinoids in the elevated plus maze. J. Pharmacol. Exp. Ther. 253:1990;1002-1009.
29. Paton G.S., Pertwee R.G., Davies S.N. Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice. Neuropharmacology. 37:1998;1123-1130.
30. Pearce J.M., Roberts A.D., Good M. Hippocampal lesions disrupt navigation based on cognitive maps but not heading vectors. Nature. 396:1998;75-77.
31. Shen M., Thayer S.A. The cannabinoid agonist Win 55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neurons. Brain Res. 783:1998;77-84.
32. Shen M., Piser T.M., Seybold V.S., Thayer S.A. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. J. Neurosci. 16:1996;4322-4334.
33. Sieradzan K.A., Fox S.H., Hill M., Dick J.P., Crossman A.R., Brotchie J.M. Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. Neurology. 57:2001;2108-2111.
34. Stark P., Dews P.B. Cannabinoids: I. Behavioral effects. J. Pharmacol. Exp. Ther. 214:1980;124-130.
35. Stark P., Henderson J.K. Increased reactivity in rats caused by septal lesions. Int. J. Neuropharmacol. 5:1966;379-383.
36. Sullivan J.M. Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons. J. Neurophysiol. 82:1999;1286-1294.
37. Sullivan J.M. Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids. Learn. Mem. 7:2000;132-139.
38. Terranova J.P., Michaud J.C., Le Fur G., Soubrie P. Inhibition of long-term potentiation in rat hippocampal slices by anandamide and Win 55,212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors. Naunyn Schmiedebergs Arch. Pharmacol. 352:1995;576-579.
39. The Council of the European Communities Council directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposed (86/609/EEC). 1986;1-27.
40. Varvel S.A., Hamm R.J., Martin B.R., Lichtman A.H. Differential effects of delta 9-THC on spatial reference and working memory in mice. Psychopharmacology (Berl). 157:2001;142-150.
41. Ward A., Holmes B. Nabilone. A preliminary review of its pharmacological properties and therapeutic use. Drugs. 30:1985;127-144.