Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors

Lancet

Volumn 353, Issue 9152, 1999, Pages 560-

  Hamann, W ^a   Di Vadi, P P ^b  

^a GUY S HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL LEWISHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTOR; NABILONE; NALOXONE;

ANALGESIA; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; PRIORITY JOURNAL; TREMOR;

EID: 0344527711     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)05429-4     Document Type: Article

References (5)

1. Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365: 61-65.
2. Herzberg U, Eliav E, Bennet GJ, Kopin IJ. The analgesic effects of R (+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett 1997; 221: 157-60.
3. Reche I, Fuentes JA, Ruiz-Gayo M. Potentiation of Δ-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of μ- and κ-opioid receptors. Eur J Pharmacol 1996; 318:11-16.
4. Tanda G, Pontieri FE, Di Chiara G. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μ opioid receptor mechanism. Science 1997; 276: 2048-50.
5. Meng ID, Manning BH, Martin WJ, Fields HL. An analgesia circuit activated by cannabinoids. Nature 1998; 395: 381-83.