Sildenafil in the treatment of pulmonary hypertension;Sildenafilo en el tratamiento de la hipertensión pulmonar

Anales de Pediatria

Volumn 59, Issue 1, 2003, Pages 110-113

  Garcia Martinez E ^b   Ibarra de la Rosa, I ^b   Perez Navero J L ^a   Tejero Mateo, I ^a   Exposito Montes J F ^b   Suarez de Lezo y Cruz Conde J ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Hospital Universitario Reina Sofia ^*

Author keywords

Mitral stenosis; Persistent ductus arteriosus; Pulmonary hypertension; Sildenafil; Treatment

Indexed keywords

ENDOTHELIN 1; MILRINONE; NITRIC OXIDE; PROSTACYCLIN; SILDENAFIL; THROMBOXANE A2;

ARTICLE; CASE REPORT; CONGESTIVE HEART FAILURE; DRUG EFFICACY; HEART LEFT ATRIUM PRESSURE; HUMAN; HYPOTENSION; INFANT; LUNG ARTERY PRESSURE; MITRAL VALVE STENOSIS; PATENT DUCTUS ARTERIOSUS; PULMONARY HYPERTENSION;

EID: 0043166631     PISSN: 16954033     EISSN: None     Source Type: Journal    
DOI: 10.1157/13048797     Document Type: Article

References (18)

1. Barst RJ, Rubin LJ, Mc Goon. Survival in primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991;115:343-9.
2. Rubin LJ. Primary pulmonary hypertension. N Engl J Med 1997; 336:111-7.
3. Abrams D, Schulze-Neick I, Magee G. Sidenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Heart 2000;84:E2.
4. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific vasodilator in patients with pulmonary arterial hypertension; comparison with inhaled nitric oxide. Circulation 2002;105:2398-403.
5. Bigatello LM, Hess D, Dennehy KC, Medoff BD, Hurford WE. Sidenafil can increase the response to inhaled nitric oxide. Anesthesiology 2000;92:1827-9.
6. Lodato RF. Viagra for impotence of pulmonary vasodilator therapy? Am J Res Crit Care Med 2001;163:312-3.
7. Hipertensión arterial pulmonar: Documento de consenso. Sociedad Española de Cardiología, Sociedad Española de Neumología y Cirugía Torácica. Madrid: Meditex, 2002.
8. Rubin LJ. Therapy of pulmonary hypertension: Targeting mechanism with selective trreatment delivery. Crit Care Med 2001;29:1086.
9. Wheeler W, Hayes S, Nguyen N, Cilla AM, Rybowicz J, Jones CC, et al. Sidenafil- a possible treatment for acute pulmonary hypertension during cardiac surgery. BUMC Proceedings 2002; 15:13-5.
10. Atz AM, Wessel DL. Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. Anesthesiology 1999;91:307-10.
11. Zhao L, Mason NA, Morrell NW, Kojonaztrov B, Sadykov A, Maripov A, et al. Sildenafil inhibits hipoxia-induced pulmonary hypertension. Circulation 2001;104:424.
12. Weimann J, Ullrich R, Hromi J, Fujino Y, Clark MW, Bloch KD, et al. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology 2000;92:1702-12.
13. Ichinoise F, Erana-García J, Hiromi BA, Raveh Y, Jones R, Krim L, et al. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med 2001;29:1000-5.
14. Ghofrani HA, Wiedemann R, Rose F, Olschewski H, Schermuly RT, Weissmann N, et al. Combination therapy with oral sildenafil and inhaled nitric oxide for severe pulmonary hypertension. Ann Intern Med 2002;136:515-22.
15. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: Comparision with nitric oxide. Circulation 2002;105:2398-403.
16. Wilkens H, Guth A, König J, Forestier N, Cremers B, Hennen B, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001;104: 1218.
17. Sayin T, Zenci M. Sildenafil in primary pulmonary hypertension-is there a subset of patient who respond favourably? Can J Cardiol 2002;18:676-8.
18. Sheckerdemian LS, Ravn HB, Penny DJ. Intravenous sildenafil lowers pulmonary vascular resitance in a model of neonatal pulmonary hypertension. Am J Respir Crit Care Med 2002;165: 1098-102.