The 5-HT1A receptor antagonist WAY 100635 improves rats performance in different models of amnesia evaluated by the object recognition task

Brain Research

Volumn 983, Issue 1-2, 2003, Pages 215-222

  Pitsikas, Nikolaos ^a   Rigamonti, Antonello E ^b   Cella, Silvano G ^b   Muller, Eugenio E ^b  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

5 HT1A receptor; Acquisition; Object recognition; Scopolamine; Storage; WAY 100635

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SCOPOLAMINE; SEROTONIN 1A ANTAGONIST;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; INFORMATION RETRIEVAL; MALE; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; REINFORCEMENT; SEROTONINERGIC SYSTEM; TASK PERFORMANCE; TREATMENT OUTCOME;

EID: 0043162028     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)03091-9     Document Type: Article

References (28)

1. Altman H.J., Normile H.J. What is the nature of the role of the serotonergic nervous system in learning and memory? Prospects for development of an effective treatment strategy for senile dementia. Neurobiol. Aging. 9:1988;627-638.
2. Bartolini L., Casamenti F., Pepeu G. Aniracetam restores object recognition impaired by age, scopolamine and nucleus basalis lesions. Pharmacol. Biochem. Behav. 53:1996;277-283.
3. Bianchi C., Siniscalchi A., Beani L. 5-HT1A agonists increase and 5-HT3 agonists decrease acetylcholine efflux from the cerebral cortex of freely-moving guinea-pigs. Br. J. Pharmacol. 101:1990;448-452.
4. Boast C., Bartolomeo A.C., Morris H., Moyer J.A. 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. Neurobiol. Learn. Mem. 71:1999;259-271.
5. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur. J. Pharmacol. 283:1995;133-139.
6. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid. Brain Res. 774:1997;167-174.
7. Cassel J.C., Jeltsch H. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience. 69:1995;1-41.
8. Cavoy A., Delacour J. Spatial but not object recognition is impaired by aging in rats. Physiol. Behav. 53:1993;527-530.
9. Consolo S., Ramponi S., Ladinsky H., Baldi G. A critical role for D1 receptors in the 5HT1A-mediated facilitation of in vivo acetylcholine release in rat frontal cortex. Brain Res. 707:1996;320-323.
10. Deschaux O., Bizot J.C., Goyffon M. Apamin improves learning in an object recognition task in rats. Neurosci. Lett. 222:1997;159-162.
11. Dringenberg H.C., Zalan R.M. Serotonin-dependent maintenance of spatial performance and electroencephalography activation after cholinergic blockade: effects of serotonergic receptor antagonists. Brain Res. 837:1999;242-253.
12. Ennaceur A., Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1. Behavioral data. Behav. Brain Res. 31:1988;47-59.
13. 1A receptor antagonist. Behav. Brain Res. 73:1996;337-353.
14. 1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281:1995;81-88.
15. 1A receptors in a mouse passive avoidance paradigm. Jpn. J. Pharmacol. 84:2000;418-424.
16. 1A receptor in working memory. Psychopharmacology. 9:1995;242-250.
17. Hunter B., Zornetzer S.F., Jarvik M.E., McGaugh J.L. Modulation of learning and memory: effects of drugs influencing neurotransmitters. Iversen L.L., Iversen S.D., Snyder S.H. Handbook of Psychopharmacology. Vol. 19:1988;531-577 Plenum, New York.
18. 1A receptor enhances acetylcholine release in conscious rats. J. Neurochem. 62:1994;1804-1808.
19. Koyama T., Nakajima Y., Fujii T., Kawashima K. Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY×3702 in freely moving rats. Neurosci. Lett. 265:1999;33-36.
20. McEntee W.J., Crook T.H. Serotonin, memory and the aging brain. Psychopharmacology. 103:1991;143-149.
21. Meneses A., Hong E. 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats. Neurobiol. Learn. Mem. 71:1999;207-218.
22. Pitsikas N., Rigamonti A.E., Cella S.G., Locatelli V., Sala M.E., Muller E.E. Effects of molsidomine on scopolamine-induced amnesia and hypermotility in the rat. Eur. J. Pharmacol. 426:2001;193-200.
23. Pitsikas N., Rigamonti A.E., Cella S.G., Muller E.E. Effects of the nitric oxide donor molsidomine on different memory components as assessed in the object-recognition task in the rat. Psychopharmacology. 162:2002;239-245.
24. Robbins T.W. Arousal systems and attentional processes. Biol. Psychol. 45:1997;57-71.
25. Saxena P.R. Serotonin receptors: subtypes, functional responses and therapeutic relevance. Pharmacol. Ther. 66:1995;339-368.
26. Steckler T., Drinkenburg W.H.I.M., Sahgal A., Aggleton J.P. Recognition memory in rats.-I Concepts and classification. Prog. Neurobiol. 54:1998;289-311.
27. Wilkinson L.O., Dourish C.T. Serotonin and animal behavior. Peroutka S.J. Serotonin Receptor Subtypes: Basic and Clinical Aspects. 1991;147-210 Wiley Liss, New York.
28. Wilkinson L.O., Middlemiss D.N., Hutson P.H. 5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo. J. Pharmacol. Exp. Ther. 270:1994;656-664.