The angiotensin II receptor (Agtr1a): Functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse

Physiological Genomics

Volumn 14, Issue , 2003, Pages 83-93

  Wong, Clifford ^a   Mahapatra, Nitish R ^a   Chitbangonsyn, Surin ^a   Mahboubi, Payam ^a   Mahata, Manjula ^a   Mahata, Sushil K ^a   O'Connor, Daniel T ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Hypertension

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; MESSENGER RNA; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR;

ADOLESCENT; ADRENAL GLAND; AGTR1A GENE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BLOOD PRESSURE; CELL STRAIN; CHROMAFFIN CELL; CHROMOSOME 13; CONSENSUS SEQUENCE; EXON; GC RICH SEQUENCE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE STRUCTURE; GENETIC LINKAGE; GENETIC POLYMORPHISM; HYPERTENSION; INTRON; MALE; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; MUS MUSCULUS; MUS SPRETUS; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; TATA BOX; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; DBA MOUSE; DNA SEQUENCE; GENETIC MARKER; GENETIC VARIABILITY; GENETICS; METABOLISM; METHODOLOGY; MURIDAE; PHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; MUS; MUS MUSCULUS; MUS SPRETUS; MUSCULUS;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CELL LINE; CHROMAFFIN CELLS; CONSERVED SEQUENCE; EXONS; GENETIC MARKERS; INTRONS; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; MURIDAE; PC12 CELLS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

EID: 0043128521     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00162.2002     Document Type: Article

References (37)

1. Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, and Scott J. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21: 76-83, 1999.
2. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, and Soubrier F. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 24: 63-69, 1994.
3. Curnow KM, Pascoe L, Davies E, White PC, Corvol P, and Clauser E. Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms. Mol Endocrinol 9: 1250-1262, 1995.
4. Furuta H, Guo DF, and Inagami T. Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun 183: 8-13, 1992.
5. Guo DF and Inagami T. The genomic organization of the rat angiotensin II receptor AT1B. Biochim Biophys Acta 1218: 91-94, 1994.
6. Hamet P, Pausova Z, Adarichev V, Adaricheva K, and Tremblay J. Hypertension: genes and environment. J Hypertens 16: 397-418, 1998.
7. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, and Weinberger DR. Serotonin transporter genetic variation and the response of the human amygdala. Science 297: 400-403, 2002.
8. Healy DP, Maciejewski AR, and Printz MP. Autoradiographic localization of [125I]-angiotensin II binding sites in the rat adrenal gland. Endocrinology 116: 1221-1223, 1985.
9. Hilbert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, De Gouyon B, Julier C, Takahasi S, and et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353: 521-529, 1991.
10. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig EH, Sharma AM, Hata A, Jeunemaitre X, and Lalouel JM. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 99: 1786-1797, 1997.
11. Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, Smithies O, and Coffman TM. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 92: 3521-3525, 1995.
12. Iwai N, Yamano Y, Chaki S, Konishi F, Bardhan S, Tibbetts C, Sasaki K, Hasegawa M, Matsuda Y, and Inagami T. Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression. Biochem Biophys Res Commun 177: 299-304, 1991.
13. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, and Lander ES. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67: 213-224, 1991.
14. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, and et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 71: 169-180, 1992.
15. Lathrop GM and Soubrier F. Genetic basis of hypertension. Curr Opin Nephrol Hypertens 3: 200-6, 1994.
16. Leonard WJ and O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 16: 293-322, 1998.
17. Leong DS, Terron JA, Falcon-Neri A, Armando I, Ito T, Johren O, Tonelli LH, Hoe KL, and Saavedra JM. Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT(1A), AT(1B) and AT(2) receptors. Neuroendocrinology 75: 227-240, 2002.
18. Lodish H, Baltimore D, Berk A, Zipursky SL, Matsudaira P, and Darnell J. Molecular Cell Biology. New York: Scientific American Books, Freeman, 1999, p. 500.
19. Martineau D, Yamaguchi N, and Briand R. Inhibition by BMS 186295, a selective nonpeptide AT1 antagonist, of adrenal catecholamine release induced by angiotensin II in the dog in vivo. Can J Physiol Pharmacol 73: 459-464, 1995.
20. Mayor C, Brudno M, Schwartz JR, Poliakov A, Rubin EM, Frazer KA, Pachter LS, and Dubchak I. VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16: 1046-1047, 2000.
21. Murasawa S, Matsubara H, Mori Y, Kijima K, Maruyama K, and Inada M. Identification of a negative cis-regulatory element and trans-acting protein that inhibit transcription of the angiotensin II type la receptor gene. J Biol Chem 270: 24282-24286, 1995.
22. Murphy TJ, Alexander RW, Griendling KK, Runge MS, and Bernstein KE. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 351: 233-236, 1991.
23. Poch E, Gonzalez D, Giner V, Bragulat E, Coca A, and de La Sierra A. Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Hypertension 38: 1204-1209, 2001.
24. Poirier O, Georges JL, Ricard S, Arveiler D, Ruidavets JB, Luc G, Evans A, Cambien F, and Tiret L. New polymorphisms of the angiotensin II type 1 receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Hypertens 16: 1443-1447, 1998.
25. Sasamura H, Hein L, Krieger JE, Pratt RE, Kobilka BK, and Dzau VJ. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun 185: 253-259, 1992.
26. Schlager G. Biometrical genetic analysis of blood pressure level in the genetically hypertensive mouse. Clin Exp Hypertens 16: 809-824, 1994.
27. Schlager G. Genetic hypertension in mice. In: Handbook of Hypertension, edited by Genten D and DeJong W. Amsterdam, Netherlands: Elsevier, 1994, p. 158-172.
28. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, and Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71: 70-77, 2001.
29. Sugiyama F, Churchill GA, Li R, Libby LJM, Carver T, Yagami K, John SWM, and Paigen B. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10: 5-12, 2002. First published April 30, 2002; 10.1152/physiolgenomics.00002.2002.
30. Takahashi N, Murakami H, Kodama K, Kasagi F, Yamada M, Nishishita T, and Inagami T. Association of a polymorphism at the 5′-region of the angiotensin II type 1 receptor with hypertension. Ann Hum Genet 64: 197-205, 2000.
31. Takeuchi K, Alexander RW, Nakamura Y, Tsujino T, and Murphy TJ. Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene. Circ Res 73: 612-621, 1993.
32. Timmermans PB, Wong PC, Chiu AT, and Herblin WF. Nonpeptide angiotensin II receptor antagonists. Trends Pharmacol Sci 12: 55-62, 1991.
33. van Geel PP, Pinto YM, Voors AA, Buikema H, Oosterga M, Crijns HJ, and van Gilst WH. Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased response to angiotensin II in human arteries. Hypertension 35: 717-721, 2000.
34. Wang WY, Zee RY, and Morris BJ. Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Clin Genet 51: 31-34, 1997.
35. Wright FA, O'Connor DT, Roberts E, Kutey G, Berry CC, Yoneda LU, Timberlake D, and Schlager G. Genome scan for blood pressure loci in mice. Hypertension 34: 625-630, 1999.
36. Yoshida H, Kakuchi J, Guo DF, Furuta H, Iwai N, van der Meer-de Jong R, Inagami T, and Ichikawa I. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun 186: 1042-1049, 1992.
37. Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, and Rieder MJ. Localization of a small genomic region associated with elevated ACE. Am J Hum Genet 67: 1144-1153, 2000.