Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: In vitro characterization and in vivo factors affecting biodistribution

Pharmaceutical Research

Volumn 20, Issue 8, 2003, Pages 1239-1248

  Park, Chung Gyu ^a,c,d   Thiex, Natalie W ^a   Lee, Kyung Mi ^b   Szot, Gregory L ^c   Bluestone, Jeffery A ^c   Lee, Kyung Dall ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

B7 costimulatory molecules; CTLA4Ig; Islet transplantation; Liposomes; Targeting

Indexed keywords

CHOLESTEROL; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FC RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; LIPOSOME; MALEIMIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; ENCAPSULATION; HYBRIDOMA CELL CULTURE; INTERNALIZATION; ISOTOPE LABELING; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD80; BONE MARROW CELLS; CELLS, CULTURED; DOWN-REGULATION; IMMUNOCONJUGATES; INJECTIONS, INTRAPERITONEAL; ISLETS OF LANGERHANS TRANSPLANTATION; LIPOSOMES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0043127377     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025057216492     Document Type: Article

References (34)

1. D. J. Lenschow, T. L. Walunas, and J. A. Bluestone. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258 (1996).
2. P. S. Linsley, W. Brady, M. Urnes, L. S. Grosmaire, N. K. Damle, and J. A. Ledbetter. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:561-569 (1991).
3. A. V. Collins, D. W. Brodie, R. J. C. Gilbert, A. Iaboni, R. Manso-Sancho, B. Walse, and D. I. Stuart, P. A. v. d. Merwe, and S. J. Davis. The interaction properties of costimulatory molecules revisited. Immunity 17:201-210 (2002).
4. P. S. Linsley, P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792-795 (1992).
5. D. J. Lenschow, Y. Zeng, J. R. Thistlethwaite, A. Montag, W. Brady, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789-792 (1992).
6. L. A. Turka, P. S. Linsley, H. Lin, W. Brady, J. M. Leiden, R. Q. Wei, M. L. Gibson, X. G. Zheng, S. Myrdal, D. Gordon, T. Bailey, S. F. Bolling, and C. B. Thompson. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA 89:11102-11105 (1992).
7. B. K. Finck, P. S. Linsley, and D. Wofsy. Treatment of murine lupus with CTLA4Ig. Science 265:1225-1227 (1994).
8. S. D. Miller, C. L. Vanderlugt, D. J. Lenschow, J. G. Pope, N. J. Karandikar, M. C. Dal Canto, and J. A. Bluestone. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739-745 (1995).
9. P. J. Perrin, D. Scott, L. Quigley, P. S. Albert, O. Feder, G. S. Gray, R. Abe, C. H. June, and M. K. Racke. Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154:1481-1490 (1995).
10. N. D. Griggs, S. S. Agersborg, R. J. Noelle, J. A. Ledbetter, P. S. Linsley, and K. S. Tung. The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells. J. Exp. Med. 183:801-810 (1996).
11. N. Harris, C. Campbell, G. Le Gros, and F. Ronchese. Blockade of CD281B7 co-stimulation by mCTLA4-Hgamma1 inhibits antigen- induced lung eosinophilia but not Th2 cell development or recruitment in the lung. Eur. J. Immunol. 27:155-161 (1997).
12. J. R. Abrams, S. L. Kelley, E. Hayes, T. Kikuchi, M. J. Brown, S. Kang, M. O. Lebwohl, C. A. Guzzo, B. V. Jegasothy, P. S. Linsley, and J. G. Krueger. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J. Exp. Med. 192:681-694 (2000).
13. M. G. Levisetti, P. A. Padrid, G. L. Szot, N. Mittal, S. M. Meehan, C. L. Wardrip, G. S. Gray, D. S. Bruce, J. R. Thistlethwaite Jr., and J. A. Bluestone. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J. Immunol. 159:5187-5191 (1997).
14. A. D. Kirk, D. M. Harlan, N. N. Armstrong, T. A. Davis, Y. Dong, G. S. Gray, X. Hong, D. Thomas, J. H. Fechner Jr., and S. J. Knechtle. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. USA 94:8789-8794 (1997).
15. N. R. Srinivas, R. S. Weiner, G. Warner, W. C. Shyu, T. Davidson, C. G. Fadrowski, L. K. Tay, J. S. Lee, D. S. Greene, and R. H. Barbhaiya. Pharmacokinetics and pharmacodynamics of CTLA4Ig (BMS-188667), a novel immunosuppressive agent, in monkeys following multiple doses. J. Pharm. Sci. 85:1-4 (1996).
16. D. D. Lasic and D. Papahadjopoulos. Liposomes revisited. Science 267:1275-1276 (1995).
17. K.-D. Lee, Y. K. Oh, D. A. Portnoy, and J. A. Swanson. Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes. J. Biol. Chem. 271:7249-7252 (1996).
18. C. Provoda and K.-D. Lee. Bacterial pore-forming hemolysins and their use in the cytosolic delivery of macromolecules. Adv. Drug Deliv. Rev. 41:209-221 (2000).
19. D. Papahadjopoulos, T. M. Allen, A. Gabizon, E. Mayhew, K. Matthay, S. K. Huang, K. D. Lee, M. C. Woodle, D. D. Lasic, C. Redemann, and F. J. Martin. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA 88:11460-11464 (1991)
20. D. Kirpotin, J. W. Park, K. Hong, S. Zalipsky, W. L. Li, P. Carter, C. C. Benz, and D. Papahadjopoulos. Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro. Biochemistry 36:66-75 (1997).
21. C. B. Hansen, G. Y. Kao, E. H. Moase, S. Zalipsky, and T. M. Allen. Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures. Biochim. Biophys. Acta 1239:133-144 (1995).
22. T. M. Allen. Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trends Pharmacol. Sci. 15:215-220 (1994).
23. T. Ishida, D. L. Iden, and T. M. Allen. A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 460:129-133 (1999).
24. J. W. Park, D. B. Kirpotin, K. Hong, R. Shalaby, Y. Shao, U. B. Nielsen, J. D. Marks, D. Papahadjopoulos, and C. C. Benz. Tumor targeting using anti-her2 immunoliposomes. J. Control. Release 74:95-113 (2001).
25. G. Girolomoni, G. Zambruno, R. Manfredini, V. Zacchi, S. Ferrari, A. Cossarizza, and A. Giannetti. Expression of B7 costimulatory molecule in cultured human epidermal Langerhans cells is regulated at the mRNA level. J. Invest. Dermatol. 103:54-59 (1994).
26. E. L. Racoosin and J. A. Swanson. Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J. Exp. Med. 170:1635-1648 (1989).
27. D. D. Spragg, D. R. Alford, R. Greferath, C. E. Larsen, K. D. Lee, G. C. Gurtner, M. I. Cybulsky, P. F. Tosi, C. Nicolau, and M. A. Gimbrone Jr. Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc. Natl. Acad. Sci. USA 94:8795-8800 (1997).
28. D. L. Daleke, K. Hong, and D. Papahadjopoulos. Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assay. Biochim. Biophys. Acta 1024:352-366 (1990).
29. R. M. Straubinger, D. Papahadjopoulos, and K. L. Hong. Endocytosis and intracellular fate of liposomes using pyranine as a probe. Biochemistry 29:4929-4939 (1990).
30. P. E. Lacy and M. Kostianovsky. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39 (1967).
31. T. Allen and A. Chonn. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223:42-46 (1987).
32. T. Allen. Stealth liposomes: avoiding reticuloendothelial uptake. In Liposomes in the Therapy of Infectious Diseases and Cancer, Vol. 89, UCLA Symposium on Molecular and Cellular Biology, Alan R. Liss, Inc., New York, 1989 pp. 405-415.
33. K.-D. Lee, S. Nir, and D. Papahadjopoulos. Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes. Biochemistry 32:889-899 (1993).
34. K. Maruyama, N. Takahashi, T. Tagawa, K. Nagaike, and M. Iwatsuru. Immunoliposomes bearing polyethyleneglycol-coupled Fab' fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo. FEBS Lett. 413:177-180 (1997).