Sialic acid 9-O-acetylesterase catalyzes the hydrolyzing reaction from alacepril to deacetylalacepril

Pharmaceutical Research

Volumn 20, Issue 8, 2003, Pages 1309-1316

  Usui, Shigeyuki ^a   Kubota, Masafumi ^a   Iguchi, Kazuhiro ^a   Kiho, Tadashi ^a   Sugiyama, Tadashi ^b   Katagiri, Yoshihiro ^b   Hirano, Kazuyuki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Alacepril; Carboxylesterase; Hydrolase; Sialic acid 9 O acetylesterase; Thiolesterase

Indexed keywords

1 NAPHTHYL ACETATE; ALACEPRIL; ALACEPRIL THIOLESTERASE; AMMONIUM SULFATE; ANIRACETAM; BENAZEPRIL; CAMOSTAT; DEACETYLALACEPRIL; DILAZEP; DILTIAZEM; FLAVOXATE; FLUTAMIDE; HYDROXYAPATITE; INDOMETACIN; IRINOTECAN; OXYBUTYNIN; POSATIRELIN; PRANLUKAST; PRAZOSIN; PROPIVERINE; QUINAPRIL; SEPHAROSE; SIALIC ACID; SIALIC ACID 9 O ACETYLESTERASE; SPIRONOLACTONE; TEMOCAPRIL; THIOL ESTER HYDROLASE; TIARAMIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG PURIFICATION; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; LIVER CYTOSOL; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; REACTION ANALYSIS;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CAPTOPRIL; CHROMATOGRAPHY, LIQUID; HYDROLYSIS; LIVER; MALE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE ANALYSIS, PROTEIN; SUBSTRATE SPECIFICITY;

EID: 0043126984     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025073720126     Document Type: Article

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