Purification and partial characterization of an indomethacin hydrolyzing enzyme from pig liver

Pharmaceutical Research

Volumn 13, Issue 9, 1996, Pages 1327-1330

  Terashima, Keisuke ^a   Takai, Satomi ^a   Usami, Yoshiko ^a   Adachi, Tetsuo ^a   Sugiyama, Tadashi ^b   Katagiri, Yoshihiro ^b   Hirano, Kazuyuki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

Author keywords

aniracetam; carboxylesterase; indomethacin; indomethacin hydrolyzing enzyme

Indexed keywords

INDOMETACIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DEACYLATION; DEMETHYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ISOLATION; HUMAN; HUMAN TISSUE; HYDROXYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SWINE;

EID: 0029958427     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016061614399     Document Type: Article

References (15)

1. M. A. Heymann, A. M. Rudolph, and N. H. Silverman. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N. Engl. J. Med. 295:530-533 (1976).
2. N. Futaki, S. Takahashi, M. Yokoyama, I. Arai, S. Higuchi, and S. Otomo. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47:55-59 (1994).
3. M. Clozel, K. Beharry, and J. V. Aranda. Indomethacin metabolism in liver microsomes during postnatal development in the rat. Biol. Neonate 50:83-90 (1986).
4. M. A. Evans, C. Papazafiratou, R. Bhat, and D. Vidyasagar. Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytes. Prdiatr. Res. 15:1406-1410 (1981).
5. R. E. Harman, M. A. P. Meisinger, G. E. Davis, and F. A. Kuehl, Jr. The metabolites of indomethacin. a new anti-inflammatory drug. J. Pharmacol. Exp. Ther. 143:215-220 (1964).
6. D. E. Duggan, A. F. Hogans, K. C. Kwan, and F. G. McMahon. The metabolism of indomethacin in man. J. Pharmacol. Exp. Ther. 181:563-575 (1972).
7. M. Sugiura, Y. Iiizumi, T. Adachi, Y. Ito, K. Hirano, and S. Sawaki. Studies on human urinary and renal esterases that migrate to the γ-globulin region upon cellulose acetate electrophoresis. Chem. Pharm. Bull. 29:2920-2927 (1981).
8. K. Krisch. Reaction of a microsomal esterase from hog-liver with diethyl ρ-nitrophenyl phosphate. Biochim. Biophys. Acta. 122:265-280 (1966).
9. U.K. Laemmli. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685 (1970).
10. M. Matsushima, H. Inoue, M. Ichinose, S. Tsukada, K. Miki, K. Kurokawa, T. Takahashi, K. Takahashi. The nucleotide and deduced amino acid sequences of porcine liver proline-β-naphtylamidase. FEBS Lett. 293:37-41 (1991).
11. K. Aida, R. Moore, and M. Negishi. Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. Biochim. Biophys. Acta. 1174:72-74 (1993).
12. M. Hosokawa, T. Maki, and T. Satoh. Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans. Arch. Biochem. Biophys. 277:219-227 (1990).
13. M. Mishima, S. Kobayashi, R. Hashida, T. Yuzuriha, T. Sato, and T. Satoh. Enzymic hydrolysis of indomethacin famesil, a prodrug of indomethacin, by carboxylesterase in cultured synovial cells. Res. Commun. Chem. Pathol. Pharmacol. 72:183-190 (1991).
14. I. L. Nutoff, J. S. Nixon, R. J. Francis, L. R. Klevans, M. Brewster, J. Budd, A. T. Patel, J. Wenger, and E. Worth. Biological properties of the angiotensin-converting enzyme inhibitor cilazapril. J. Cardiovasc. Pharmacol. 7:569-580 (1985).
15. P. E. O. Williams, A. N. Brown, S. Rajaguru, R. J. Francis, G. E. Walters, J. McEwen, and C. Dumin. The pharmacokinetics and bioavailability of cilazapril in normal man. Brit. J. Clin. Pharmacol. 27:181S-188S (1989).