pKa and volume of residue one influence δ/μ opioid binding: QSAR analysis of tyrosine replacement in a nonselective deltorphin analogue

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 17, 2003, Pages 3761-3768

  Heyl, Deborah L ^a   Schullery, Stephen E ^a   Renganathan, Kutralanathan ^a   Jayamaha, Malika N ^a   Rodgers, David W ^a   Traynor, John R ^b  

^a EASTERN MICHIGAN UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; DELTA OPIATE RECEPTOR; DELTORPHIN; MU OPIATE RECEPTOR; OPIATE PEPTIDE; PHENOL; PHENYLALANINE DERIVATIVE; TYROSINE; OLIGOPEPTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HYDROGEN BOND; NONHUMAN; PROTEIN CONFORMATION; PROTEIN MODIFICATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; SYNTHESIS;

AMPHIBIA; PHYLLOMEDUSA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; TYROSINE;

EID: 0043123440     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00329-8     Document Type: Article

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