Binding to δ and μ opioid receptors by deltorphin I/II analogues modified at the Phe3 and Asp4/Glu4 side chains: A report of 32 new analogues and a QSAR study

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 12, 1997, Pages 2221-2234

  Schullery, Stephen E ^a   Mohammedshah, Tasneem ^a   Makhlouf, Hafida ^a   Marks, Eleanor L ^a   Wilenkin, Benjamin S ^a   Escobar, Sharleen ^a   Mousigian, Carol ^b   Heyl, Deborah L ^a  

^a EASTERN MICHIGAN UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Binding; Deltorphin; Opioid; Peptide; QSAR

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN; DELTORPHIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN HOMOGENATE; CHEMICAL MODIFICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; MULTIPLE REGRESSION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALGORITHMS; AMINO ACID SUBSTITUTION; ANALGESICS, OPIOID; KINETICS; LIGANDS; OLIGOPEPTIDES; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031450774     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00163-6     Document Type: Article

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