Determinants of intramyocellular lipid concentrations in rat hindleg muscle

Magnetic Resonance in Medicine

Volumn 50, Issue 2, 2003, Pages 242-248

  Neumann Haefelin, Claudia ^a   Kuhlmann, Johanna ^a   Belz, Ulrich ^a   Kalisch, Juergen ^a   Quint, Manfred ^a   Gerl, Martin ^a   Juretschke, Hans Paul ^a   Herling, Andreas W ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

1H NMR spectroscopy; Age and gender effects; IMCL; Insulin resistance; Rat muscle

Indexed keywords

INSULIN; MUSCLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1H NMR SPECTROSCOPY; AGE AND GENDER EFFECTS; IDENTICAL CONDITIONS; IMCL; INSULIN RESISTANCE; LIPID CONCENTRATION; MATCHED CONTROLS; PROTON MR SPECTROSCOPY;

RATS;

LIPID;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENDER; HINDLIMB; IN VIVO STUDY; INSULIN RESISTANCE; LEG MUSCLE; LIPID ANALYSIS; MALE; MUSCLE CELL; NONHUMAN; OBESITY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN;

EID: 0043093839     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10518     Document Type: Article

References (29)

1. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993;29:158-167.
2. Bottomley PA, Lee Y, Weiss RG. Total creatine in muscle: imaging and quantification with proton MR spectroscopy. Radiology 1997;204:403-410.
3. 1H-MR-spectroscopy. Magn Reson Med 1997;37:484-493.
4. Vock R, Hoppeler H, Claassen H, Wu DX, Billeter R, Weber JM, Taylor CR, Weibel ER. Design of the oxygen and substrate pathways. VI. Structural basis of intracellular substrate supply to mitochondria in muscle cells. J Exp Biol 1996;199(Pt 8):1689-1697.
5. 1H NMR spectroscopy study. Diabetologia 1999;42:113-116.
6. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999;48:1113-1119.
7. Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001;86:5755-5761.
8. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997;46:983-988.
9. 1H-magnetic resonance spectroscopy. Ann NY Acad Sci 2000:904:25-31.
10. Decombaz J, Fleith M, Hoppeler H, Kreis R, Boesch C. Effect of diet on the replenishment of intramyocellular lipids after exercise. Eur J Nutr 2000;39:244-247.
11. 1H-MRS). Horm Metab Res 2001:33:63-66.
12. Bachmann OP, Dahl DB, Brechtel K, Machann J, Haap M. Maier T, Loviscach M, Stumvoll M, Claussen CD, Schick F, Haring HU, Jacob S. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 2001;50:2579-2584.
13. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 1999;276(5 Pt 1):E977-E989.
14. Yokoyama Y, Horikoshi S, Takahashi T, Sato H. Low-capacity cation-exchange chromatography of ultraviolet-absorbing urinary basic metabolites using a reversed-phase column coated with hexadecylsulfonate. J Chromatogr A 2000;886:297-302.
15. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997;129:35-43.
16. 1H MR spectra of skeletal muscle: confirmation in rats at 4.7 T in vivo and observation of changes postmortem. Magn Reson Med 1997;38:33-39.
17. in't Zandt HJ, Klomp DW, Oerlemans F, Wieringa B, Hilbers CW, Heerschap A. Proton MR spectroscopy of wild-type and creatine kinase deficient mouse skeletal muscle: dipole-dipole coupling effects and post-mortem changes. Magn Reson Med 2000;43:517-524.
18. Franke C, Kuhlmann J, Belz U, Herling AW, Juretschke H-P. Orientation dependent splitting of the intra-myocellular lipid resonance in rat muscle: an MRS study at 7T. In: Proceedings of the 9th Annual Meeting of ISMRM, Glasgow, Scotland, 2001. p 1070.
19. 1H-spectroscopic study in Zucker diabetic fatty rats. Diabetes 2003;52:138-144.
20. Guo Z, Mishra P, Macura S. Sampling the intramyocellular triglycerides from skeletal muscle. J Lipid Res 2001;42:1041-1048.
21. Dagenais GR, Tancredi RG, Zierler KL. Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J Clin Invest 1976;58:421-431.
22. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 1991;40:280-289.
23. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 1996;45:947-950.
24. Malmlof K, Din N, Johansen T, Pedersen SB. Growth hormone affects both adiposity and voluntary food intake in old and obese female rats. Eur J Endocrinol 2002;146:121-128.
25. Copeland KC, Nair KS. Acute growth hormone effects on amino acid and lipid metabolism. J Clin Endocrinol Metab 1994;78:1040-1047.
26. Campbell SE, Febbraio MA. Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle. Am J Physiol Endocrinol Metab 2001;281:E803-E808.
27. Hatta H, Atomi Y, Shinohara S, Yamamoto Y, Yamada S. The effects of ovarian hormones on glucose and fatty acid oxidation during exercise in female ovariectomized rats. Horm Metab Res 1988;20:609-611.
28. Kim HJ, Kalkhoff RK. Sex steroid influence on triglyceride metabolism. J Clin Invest 1975;56:888-896.
29. Neumann-Haefelin C, Kuhlmann J, Belz U, Kalisch J, Herling AW, Juretschke H-P. Correlation between IMCL and insulin sensitivity in Zucker diabetic fatty rats. In: Proceedings of the 10th Annual Meeting of ISMRM, Honolulu, 2002. p 1881.