Studies of the brain specificity of S100B and neuron-specific enolase (NSE) in blood serum of acute care patients

Brain Research Bulletin

Volumn 61, Issue 3, 2003, Pages 265-279

  Kleine, Tilmann O ^a,b   Benes, Ludwig ^b   Zöfel, Peter ^b  

^a Center of Nervous Diseases   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Brain damage; Cerebrospinal fluid; Creatine kinase isoenzymes; Heart damage; S100B non brain specificity; Troponin I

Indexed keywords

2 HYDROXYBUTYRATE DEHYDROGENASE; BIOLOGICAL MARKER; CREATINE KINASE ISOENZYME; NEURON SPECIFIC ENOLASE; PROTEIN S100B; TROPONIN I;

ADOLESCENT; ADULT; AGED; ANEMIA; BRAIN HEMORRHAGE; BRAIN INJURY; COMA; CONFERENCE PAPER; CONTROLLED STUDY; CONVULSION; CORRELATION ANALYSIS; DISEASE MARKER; FEMALE; HEART FAILURE; HUMAN; HYPOXIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN CONTENT; PROTEIN LOCALIZATION; PROTEIN SECRETION; TISSUE DISTRIBUTION; TISSUE INJURY; TISSUE SPECIFICITY;

EID: 0043092030     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(03)00090-X     Document Type: Conference Paper

References (71)

1. Adams J.E., Bodor G.S., Dávila-Román V.G., Delmez J.A., Apple F.S., Ladenson J.H., Jaffe A.S. Cardiac troponin I, a marker with high specificity for cardiac injury. Circulation. 88:1993;101-106.
2. Adams J.E., Sicard G.A., Allen B.T., Bridwell K.H., Lenke L.G., Dávila-Román V.G., Bodor G.S., Ladenson J.H., Jaffe A.S. Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. New Engl. J. Med. 330:1994;670-674.
3. Beaudeux L., Leger P., Dequen L., Gandjbakhch P.C., Foglietti M.-J. Influence of hemolysis on the measurement of S-100β protein and neuron-specific enolase plasma concentrations during coronary artery bypass grafting. Clin. Chem. 46:2000;989-990.
4. Bodor G.S., Porter S., Landt Y., Ladenson J.H. Development of monoclonal antibodies and an assay of cardiac troponin-I and preliminary results in suspected myocardial infarction. Clin. Chem. 38:1992;2203-2214.
5. Bodor G.S., Porterfield D., Voss E.M., Smith S., Apple F.S. Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue. Clin. Chem. 41:1995;1710-1715.
6. 2+ binding S100 proteins in normal human skin and melanocytic lesions. Br. J. Dermatol. 137:1997;39-43.
7. Cooper E.H., Pritchard J., Bailey C.C., Ninane J. Serum neuron-specific enolase in children's cancer. Br. J. Cancer. 56:1987;65-67.
8. Donato R. Functional roles of S-100 proteins, calcium-binding proteins of the EF-hand type. Biochim. Biophys. Acta. 1450:1999;191-231.
9. Elting J.-W., de Jager A.E.J., Teelken A.W., Schaaf M.J., Maurits N.M., van der Naalt J., Smit Sibinga C.Th., Sulter G.A., De Keyser J. Comparison of serum S-100 protein levels following stroke and traumatic brain injury. J. Neurol. Sci. 181:2000;104-110.
10. van Engelen B.G.M., Lamers K.J.B., Gabreels F.J.M., Wevers R.A., van Geel W.J.A., Brom G.F. Age-related changes of neuron-specific enolase, S-100 protein, and myelin basic protein concentrations in cerebrospinal fluid. Clin. Chem. 38:1992;813-816.
11. Fano G., Mariggio M.A., Angelella P., Nicoletti I., Antonica A., Fulle S., Calissano P. The S-100 protein causes an increase of intracellular calcium and death of PC12 cells. Neuroscience. 53:1993;919-925.
12. Gao F., Harries D.N.F., Sapsed-Byrne S. Neuron-specific enolase and Sangtec 100 assays during cardiac surgery: part III. Does haemolysis affect their accuracy? Perfusion. 12:1997;171-177.
13. Gazzolo D., Vinesi P., Geloso M.C., Marcelletti C., Iorio A.C., Cipriani A., Marianeschi S.M., Michetti F. S100 blood concentrations on children subjected to cardiopulmonary by-pass. Clin. Chem. 44:1998;1058-1060.
14. Gerbitz K.D. Wertigkeit der Enolase-Isoenzyme als Tumormarker. Eine Übersicht. Tumor Diagnostik & Therapie. 10:1989;45-53.
15. Gerbitz K.D., Summer J., Schumacher I., Arnold H., Kraft A., Mross K. Enolase isoenzymes as tumor markers. J. Clin. Chem. Clin. Biochem. 24:1986;1009-1016.
16. H. Greiling, A.M. Gressner (Eds.), Lehrbuch der Klinischen Chemie und Pathobiochemie, 2nd ed., Schattauer, Stuttgart, New York, 1989.
17. Haimoto H., Hosoda S., Kato K. Differential distribution of immunoreactive S100-α and S100-β proteins in normal non-nervous human tissues. Lab. Invest. 57:1987;489-498.
18. Haimoto H., Takahashi Y., Koshikawa T., Nagura H., Kato K. Immunohistochemical localisation of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab. Invest. 52:1985;257-263.
19. 2+-binding S100 proteins in the central nervous system. Neurochem. Res. 24:1999;1097-1100.
20. Herrmann M., Jost S., Kutz S., Ebert A.D., Kratz T., Wunderlich M.T., Synowitz H. Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography. J. Neurotrauma. 17:2000;113-122.
21. Hidaka H., Endo T., Kawamoto S., Yamada E., Umekawa H., Tanabe K., Hara K. Purification and characterization of adipose tissue S-100b protein. J. Biol. Chem. 258:1983;2705-2709.
22. Hullin D.A., Brown K., Kynoch P.A.M., Smith C., Thompson R.J. Purification, radioimmunoassay, and distribution of human brain 14-3-2 protein (nervous-system specific enolase) in human tissues. Biochim. Biophys. Acta. 628:1980;98-108.
23. Ishiguro Y., Kato K., Ito T., Nagaya M. Determination of three enolase isoenzymes and S-100 protein in various tumors in children. Cancer Res. 43:1983;6080-6084.
24. Ishiguro Y., Kato K., Shimizu A., Ito T., Nagaya M. High levels of immunoreactive nervous system-specific enolase in sera of patients with neuroblastoma. Clin. Chim. Acta. 121:1982;173-180.
25. Jimi T., Wakayama Y., Shibuva S., Nakata H., Tomaru T., Takahashi Y., Kosaka K., Asano T., Kato K. High levels of nervous system-specific proteins in cerebrospinal fluid in patients with early stage Creutzfeldt-Jakob disease. Clin. Chim. Acta. 211:1992;37-46.
26. Johnsson P. Markers of cerebral ischemia after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 10:1996;120-126.
27. Johnsson P., Lundqvist C., Lindgren A., Ferencz I., Alling C., Stahl E. Cerebral complications after cardiac surgery assessed by S-100 and NSE levels in blood. J. Cardiothorac. Vasc. Anesth. 9:1995;694-699.
28. Jönsson H., Johnsson P., Alling C., Bäckström M., Bergh C., Blomquist S. S100β after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome. Ann. Thorac. Surg. 68:1999;2202-2208.
29. Kärkelä J., Bock E., Kaukinen S. CSF and serum brain-specific creatine kinase isoenzyme (CK-BB), neuron-specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man. J. Neurol. Sci. 116:1993;100-109.
30. Kato K., Asai R., Shimizu A., Suzuki F., Ariyashi Y. Immunoassay of three enolase isoenzymes in human serum and in blood cells. Clin. Chim. Acta. 127:1983;353-363.
31. Kato K., Ishiguro Y., Suzuki F., Ito A., Semba R. Distribution of nervous system-specific forms of enolase in peripheral tissues. Brain Res. 237:1982;441-448.
32. o (αα) protein is mainly located in the heart and striated muscles. Biochim. Biophys. Acta. 842:1985;146-150.
33. Kato K., Suzuki F., Shimizu A., Shinohara H., Semba R. Highly sensitive immunoassay for rat brain-type creatine kinase: determination in isolated Purkinje cells. J. Neurochem. 46:1986;1783-1788.
34. T.O. Kleine, Nervensystem, in: H. Greiling, A.M. Gressner (Eds.), Lehrbuch der Klinischen Chemie und Pathobiochemie, Schattauer Verlag, Stuttgart, 1989, pp. 859-893.
35. Kleine T.O. Mechanisierte Zählung und Differenzierung von Liquorzellen. Lab. Med. 51:1991;51-59.
36. Kleine T.O., Naumann C. Quality assurance of clinical chemistry analytes of the daily routine: comparison with three analysers using different reagents. Le Medecin Biopathologiste. 54:1997;43-44. (Abstract).
37. T.O. Kleine, C. Naumann, Glucose-Bestimmung im Vollblut mit der Hämolysatmethode: Vergleiche zwischen manueller und vollmechanisieter Technik, in: W. Günther, H. Gunz, G. Wulff (Eds.), Instrumentalized Analytical Chemistry and Computer Technology, InComR-Bureau mit IAS mbH, Moers, 1997, p. 389.
38. Kleine T.O., Naumann C. Quality assurance of enzyme measurement: comparison of Hitachi 911 and Cobas FARA determinations at two different temperatures. Le Medecin Biopathologiste. 54:1997;43-44. (Abstract).
39. Kohira I., Tsuji T., Ishizu H., Takao Y., Wake A., Abe K., Kuroda S. Elevation of neuron-specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease. Acta Neurol. Scand. 102:2000;385-387.
40. H. Lang, Creatine Kinase Isoenzymes, Springer, Berlin, Heidelberg, New York, 1981.
41. Marangos P.J., Campbell I.C., Schmechel D.E., Murphy D.L., Goodwin F.K. Blood platelets contain a neuron-specific enolase subunit. J. Neurochem. 34:1980;1254-1258.
42. McKeating E.G., Andrews P.J.D., Mascia L. Relationship of neuron specific enolase and protein S-100 concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury. Acta Neurochir. 71:1998;117-119.
43. McNutt N.S. The S100 family of multipurpose calcium-binding proteins. J. Cutan. Pathol. 25:1998;521-529.
44. Missler U., Wiesmann M., Ehlermann P., Tronnier M., Nötzold A., Steinmeier E., Wood W.G. Validation and comparison of two solid-phase immunoassays for the quantification of S-100β in human blood. Clin. Chem. 46:2000;993-996.
45. Mokuno K., Kato K., Kawai K., Mtsuoka Y., Yanagi T., Sobue I. Neuron-specific enolase and s-100 protein levels in cerebrospinal fluid of patients with various neurological diseases. J. Neurol. Sci. 60:1983;443-451.
46. Nordby H.K., Urdal P. Creatine kinase BB in blood as index of prognosis and effect of treatment after severe head injury. Acta Neurochir. 76:1985;131-136.
47. Pahlman S., Esscher T., Bergvall P., Odelstad L. Purification and characterization of human neuron-specific enolase: radioimmunoassay development. Tumor Biol. 5:1984;127-139.
48. Persson L., Hardemark H.-G., Gustafsson J., Rundström G., Mendel-Hartvig I., Esscher T. S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke. 18:1987;911-918.
49. Raabe A., Grolms C., Keller M., Döhnert J., Sorge O., Seifert V. Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir. (Wien). 140:1998;787-792.
50. Schäfer B.W., Heizmann C.W. The S100 family of EF-hand calcium-binding proteins: functions and pathology. TIBS. 21:1996;134-140.
51. Sindic C.J.M., Chalon M.P., Cambiaso C.L., Laterre E.C., Masson P.L. Assessment of damage of the central nervous system by determination of S-100 protein in the cerebrospinal fluid. J. Neurol. Neurosurg. Psychiatry. 45:1982;1130-1135.
52. Skogseid I.M., Nordby H.K., Urdal P., Paus E., Lilleaas F. Increased serum creatine kinase BB and neuron specific enolase following head injury indicates brain damage. Acta Neurochir. (Wien). 115:1992;106-111.
53. Stefansson K., Wollmann R.L., Moore B.W., Arnason B.G.W. S-100 protein in human chondrocytes. Nature. 295:1982;63-64.
54. W. Stein, Laboratory Diagnosis of Acute Myocardial Infarction, GIT Verlag, Darmstadt, 1988.
55. Suzuki F., Kato K. Induction of adipose S-100 protein release by free fatty acids in adipocytes. Biochim. Biophys. Acta. 889:1986;84-90.
56. Suzuki F., Kato K., Nakajima T. Enhancement of adipose S-100 protein release by catecholamines. J. Biochem. 94:1983;1707-1710.
57. Suzuki F., Kato K., Nakajima T. Regulation of nervous system-specific S-100 protein and enolase levels in adipose tissue by catecholamines. J. Neurochem. 42:1984;130-134.
58. Takahashi K., Isobe T., Ohtsuki Y., Akagi T., Sonobe H., Okuyama T. Immunohistochemical study on the distribution of α and β subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch. [Cell Pathol.]. 45:1984;385-396.
59. Takahashi K., Isobe T., Ohtsuki Y., Sonobe H., Takeda I., Akagi T. Immunohistochemical localization and distribution of S-100 proteins in the human lymphoreticular system. Am. J. Pathol. 116:1984;497-503.
60. L. Thomas (Ed.), Labor und Diagnose, 5th ed., TH-Books Verlagsgesellschaft, Frankfurt/Main, 1998.
61. Thompson R.J., Graham J.G., McQueen I.N.F., Kynoch P.A.M., Brown K.W. Radioimmunoassay of brain-type creatine kinase-BB isoenzyme in human tissues and in serum of patients with neurologic disorders. J. Neurol. Sci. 47:1980;241-254.
62. o protein in blood and urine during open-heart surgery. Clin. Chem. 35:1989;1942-1944.
63. oα, 28-kDa calbindin D, S100b and CK-BB) in serum and cerebrospinal fluid after cardiac arrest. J. Neurol. Sci. 123:1994;134-139.
64. Vermuyten K., Lowenthal A., Karcher D. Detection of neuron-specific enolase concentrations in cerebrospinal fluid from patients with neurological disorders by means of a sensitive enzyme immunoassay. Clin. Chim. Acta. 187:1990;69-78.
65. K. Werdan, H.P. Schuster (Eds.), Intensivtherapie bei Sepsis und Multiorganversagen, Springer, Berlin, Heidelberg, 2000.
66. Wiesmann M., Missler U., Gottmann D., Gehring S. Plasma S-100 protein concentration in healthy adults is age- and sex-independent. Clin. Chem. 44:1998;1056-1058.
67. Witthaut R., Werdan K., Schuster H.P. Multiorgandysfunktions-Syndrom und Multiorganversagen. Internist. 39:1998;493-501.
68. Woertgen C., Rothoerl R.D., Holzschuh M., Metz C., Brawanski A. Comparison of serial S-100 and NSE serum measurements after severe head injury. Acta Neurochir. (Wien). 139:1997;1161-1165.
69. P.L. Wood (Ed.), Neuroinflammation, Mechanisms and Management, Human Press, Totowa, NJ, 1998.
70. Zimmer D.B., Cornwall E.H., Landar A., Song W. The S100 protein family: history, function, and expression. Brain Res. 37:1995;417-429.
71. P. Zöfel, Statistik verstehen. Ein Begleitbuch zur computergestützten Anwendung, Addison-Wesley, München, Boston, 2001.