Genetic variation of the platelet- surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus

Diabetologia

Volumn 46, Issue 7, 2003, Pages 984-989

  Tschoepe, D ^a   Menart, B ^a   Ferber, P ^a   Altmann, C ^b   Haude, M ^b   Haastert, B ^a   Roesen, P ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Fibrinogen receptor PIA1 PIA2 polymorphism; Platelets; Type 2 diabetes mellitus; Vascular complications

Indexed keywords

CHOLESTEROL; DNA; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT; RISK FACTOR; SINGLE STRAND CONFORMATION POLYMORPHISM; THROMBOCYTE; VASCULAR DISEASE;

AMINO ACID SUBSTITUTION; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RISK FACTORS; VARIATION (GENETICS);

EID: 0043073221     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1132-6     Document Type: Article

References (43)

1. Nathan DM, Meigs J, Singer E (1997) The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is... or is it? Lancet 350 [Suppl 1]:4-9
2. Haffner S, Lehto S, Rónnemaa T, Pyorälä K, Laakso M (1998) Mortality from coronary heart disease in subjects with type-2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New Engl J Med 339:229-234
3. Tschoepe D (1998) Coronary artery disease in diabetes mellitus: a challenge for intervention. Exp Clin Endocrinol Diabetes 106:16-24
4. Topol EJ (1998) Toward: new frontier in myocardial reperfusion therapy. Emerging platelet preeminence. Circulation 97:211-218
5. Tschoepe D, Driesch E, Schwippert B, Niewenhuis HK, Gries FA (1995) Exposure of adhesion molecules on activated platelets in patients with newly diagnosed IDDM is not normalized by near- normoglycemia. Diabetes 44:890-895
6. Tschoepe D, Roesen P, Esser J et al. (1990) Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost 17:433-439
7. Tschoepe D (1995) The activated megakaryocyte- platelet system in vascular disease: focus on diabetes. Semin Thromb Hemost 21:152-159
8. Brown A, Hong Y, Belder A de, Beeso HL, Sherword R (1997) Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscl Thromb Vasc Biol 17:802-807
9. Tschoepe D, Schwippert B, Schettler B, Kiesel U, Rothe H, Roesen P (1992) Increased GPIIBIIIA expression and altered DNA-ploidy pattern in megakaryocytes of diabetic BB-rats. Eur J Clin Invest 22:591-598
10. Levkovits J, Plow EF, Topol EJ (1995) Platelet glycoprorein IIb/IIIa receptors in cardiovascular medicine. New Engl J Med 332:1553-1559
11. Zimrin AB, Gidwitz S, Lord S et al. (1990) The genomic organization of platelet glycoprotein IIIa. J Biol Chem 265:8590-8595
12. Kunicki TJ, Newman PJ (1992) The molecular immunology of human platelet proteins. Blood 80:1386-1404
13. Weiss EJ, Bray PF, Tayback M et al. (1996) A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. New Engl J Med 334:1090-1094
14. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1193
15. Newman PJ, Derbes RS, Aster RH (1989) The human platelet alloantigens. PIA1 and PIA2 are associated with a leucine 33/proline 33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing. J Clin Invest 83:1778-1781
16. Horikawa Y, Oda N, Cox NJ et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175
17. Fox JE, Reynolds CC, Austin CD (1990) The role of calpain in stimulus-response coupling: evidence that calpain mediates agonist-induced expression of procoagulant activity in platelets. Blood 76:2510-2519
18. Croce K, Flaumenhaft R, Rivers M et al. (1999) Inhibition of calpain blocks platelet secretion, aggregation, and spreading. J Biol Chem 274:36321-36327
19. Schoenwaelder SM, Yuan Y, Jackson SP (2000) Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets. Platelets 11:189-198
20. Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF (1995) A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes PIA1 from PIA2. Tissue Antigens 46:374-381
21. Schwippert-Houtermans B, Strapatsakis S, Roesen P, Tschoepe D (2001) Evaluation of an antibody-based genotype classification of the platelet fibrinogen receptor (GPIIbIIIa). Comm Clin Cytometry 46:238-242
22. Feng D, Lindpainter K, Larson MG et al. (2001) Platelet glycoprotein IIIa PIA2 polymorphism, fibrinogen and platelet aggregability. The Framingham Heart Study. Circulation 104:140-144
23. Cannon CP, Bray PF, Ault K, Rizzo MJ, Braunwald E (1998) PIA2 polymorphism of the platelet IIbIIIa receptor: increased risk of early recurrent ischemic events in acute coronary syndromes, increased platelet aggregability, and effective platelet inhibition by an oral IIbIIIa inhibitor: Results from TIMI 12. Circulation 98 [Suppl 1]:A880
24. Ripoll L, Kereveur A, Mazoyer E et al. (1998) PIA platelet GPIIbIIIa polymorphism is associated with increased platelet aggregation and risk of ischemic stroke in the young. Circulation 98 [Suppl 1]:A2409
25. Undas A, Brummel K, Musial J, Mann K, Szczeklik A (2001) PIA2 polymorphism of β3 integrins is associated with enhanced thrombin generation and impaired anti-thrombotic action of aspirin at the site of microvascular injury. Circulation 104:2666-2672
26. Michelson AD, Furman MJ, Goldschmidt-Clermont P et al. (2000) Platelet GPIIIa PIA polymorphisms display different sensitivities to agonists. Circulation 101:1013-1018
27. Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF (2000) The PIA2 polymorphism of integrin β3 enhances outside-in signaling and adhesive functions. J Clin Invest 105:793-802
28. Scherrer U, Sartori C (2000) Defective nitric oxide synthesis: a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity. Eur J Endocrinol 142:315-323
29. Lampeter E, Homber M, Quabeck K et al. (1993) Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet 341:1243-1244
30. Kim HO, Blakemore K, Kwon OH et al. (1995) Gene frequencies of the five major human platelet antigens in African American, white, and Korean populations. Transfusion 35:863-867
31. Gardemann A, Humme J, Stricker J et al. (1998) Association of the platelet glycoprotein IIIa PIA1/A2 gene polymorphism to coronary artery disease but not to nonfatal myocardial infarction in low risk patients. Thromb Haemost 80:214-217
32. Zotz RB, Winkelmann BR, Nauck M et al. (1998) Polymorphism of platelet membrane glycoprotein IIIa: human platelet antigen 1b (HPA-1b/PIA2) is an inherited risk factor for premature myocardial infarction in coronary artery disease. Thromb Haemost 79:731-735
33. Garcia-Ribes M, Gonzales-Lamuno D, Hernandez-Estefania R et al. (1998) Polymorphism of the platelet glycoprotein IIIa gene in patients with coronary stenosis. Thromb Haemost 79:1126-1129
34. Carter AM, Ossei-Gerning N, Wilson IJ, Grant PJ (1997) Association of the platelet PIA polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bβ448 polymorphism with myocardial infarction and extent of coronary artery disease. Circulation 96:1424-1431
35. Walter DH, Schächinger V, Elsner M, Dimmeler S, Zeiher AM (1997) Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis. Lancet 350:1217-1219
36. Ridker PM, Hennekens CH, Schmitz C, Stampfer MJ, Lindpaintner K (1997) PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet 349:385-388
37. Herrmann SM, Porier O, Marques-Vidal P et al. (1997) The Leu 33/Pro polymorphism (PIA1/A2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM study. Thromb Haemost 77:1179-1181
38. Aleksic N, Nuneja H, Folsom AR et al. (2000) Platelet PIA2 allele and incidence of coronary heart disease. Results from the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 102:1901-1905
39. Scaglione L, Bergerones S, Gaschino G et al. (1998) Lack of relationship between the PIA1/PIA2 polymorphism of platelet glycoprotein IIIa and premature myocardial infarction. Eur J Clin Invest 28:385-388
40. Durante-Mangoni E, Davies GJ, Ahmed N, Ruggiero G, Tuddenham EG (1998) Coronary thrombosis and the platelet glycoprotein IIIa gene PLA2 polymorphism. Thromb Haemost 80:218-219
41. Broeckel U, Hengstenberg C, Mayer B et al. (2002) A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 30:210-214
42. Merlini PA, Niguarda O, Ardissimo D et al. (1998) Interactions between environmental and prothrombotic genetic risk factors in young survivors of myocardial infarction. Circulation 98 [Suppl 1]:A2408
43. Carter AM, Mansfield MW, Grant PJ (1998) Polymorphisms of platelet glycoproteins in relation to macrovascular disease in type 2 diabetes mellitus. Diabet Med 15:315-319