Convergent enantioselective synthesis of vinigrol, an architecturally novel diterpenoid with potent platelet aggregation inhibitory and antihypertensive properties. 1. Application of anionic sigmatropy to construction of the octalin substructure

Journal of Organic Chemistry

Volumn 68, Issue 16, 2003, Pages 6096-6107

  Paquette, Leo A ^a   Guevel, Ronan ^a,b   Sakamoto, Shuichi ^a,c   Kim In Ho, I H ^a,d   Crawford, Jason ^a,e  

^a OHIO STATE UNIVERSITY   (United States)

^b CRIT Pharma   (France)

^c ASTELLAS PHARMA INC   (Japan)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHY; NEGATIVE IONS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ENANTIOSELECTIVE SYNTHESIS;

MAGNESIUM COMPOUNDS;

ANION; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; DITERPENOID; UNCLASSIFIED DRUG; VINIGROL;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; THROMBOCYTE AGGREGATION INHIBITION; X RAY CRYSTALLOGRAPHY;

ANTIHYPERTENSIVE AGENTS; BICYCLO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; DITERPENES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLATELET AGGREGATION INHIBITORS; STEREOISOMERISM;

EID: 0043032911     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0301301     Document Type: Article

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