A genome screen for linkage in Australian sibling-pairs with multiple sclerosis

Genes and Immunity

Volumn 3, Issue 8, 2002, Pages 464-469

  Ban, M ^a,b   Stewart, G J ^b   Bennetts, B H ^b   Heard, R ^b   Simmons, R ^c   Maranian, M ^a   Compston, A ^a   Sawcer, S J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CANBERRA HOSPITAL   (Australia)

Author keywords

Genetic susceptibility; Linkage genome screen; Multiple sclerosis

Indexed keywords

ARTICLE; AUSTRALIA; CHROMOSOME 13Q; CHROMOSOME 16P; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 18P; CHROMOSOME 1Q; CHROMOSOME 20P; CHROMOSOME 2P; CHROMOSOME 3Q; CHROMOSOME 4Q; CHROMOSOME 5Q; CHROMOSOME 6Q; CHROMOSOME 7Q; CHROMOSOME 8P; CHROMOSOME 9Q; CHROMOSOME XP; CHROMOSOME XQ; CONTROLLED STUDY; GENETIC LINKAGE; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HUMAN; LINKAGE ANALYSIS; MICROSATELLITE MARKER; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SIBLING; CHROMOSOME MAP; GENE FREQUENCY; GENETICS; GENOME; METHODOLOGY;

MICROSATELLITE DNA;

AUSTRALIA; CHROMOSOME MAPPING; GENE FREQUENCY; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS); MICROSATELLITE REPEATS; MULTIPLE SCLEROSIS; SIBLINGS;

EID: 0042914324     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6363910     Document Type: Article

References (39)

1. Hogancamp WE, Rodriguez M, Weinshenker BG. The epidemiology of multiple sclerosis. Mayo Clin Proc 1997; 72: 871-878.
2. Sadovnick AD, Armstrong H, Rice GPA et al. A population based study of multiple sclerosis in twins: updated. Ann Neurol 1993; 33: 281-285.
3. Mumford CJ, Wood NW, Kellar-Wood HF et al. The British Isles survey of multiple sclerosis in twins. Neurology 1994; 44: 11-15.
4. Sadovnick AD, Ebers GC, Dyment DA, Risch NJ, the Canadian Collaborative Study Group. Evidence for genetic basis of multiple sclerosis. Lancet 1996; 347: 1728-1731.
5. Ebers GC, Sadovnick AD, Risch NJ, The Canadian Collaborative Study Group. A genetic basis for familial aggregation in multiple sclerosis. Nature 1995; 377: 150-151.
6. Dean G, McLoughlin H, Brady R, Adelstein A, Tallett-Williams J. Multiple sclerosis among immigrants in Greater London. BMJ 1976; 1: 861-864.
7. Hammond SR, de Wytt C, Maxwell IC et al. The epidemiology of multiple sclerosis in Queensland, Australia. J Neurol Sci 1987; 80: 185-204.
8. Hammond SR, McLeod JG, Millingen KS et al. The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain 1988; 111: 1-25.
9. Sawcer SJ, Jones HB, Feakes R et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosomes 6p21 and 17q22. Nat Genet 1996; 13: 464-468.
10. Haines JL, Ter-Minassian M, Bazyk A et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet 1996; 13: 469-471.
11. Ebers GC, Kukay K, Bulman DE et al. A full genome search in multiple sclerosis. Nat Genet 1996; 13: 472-476.
12. Kuokkanen S, Gschwend M, Rioux JD et al. Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 1997; 61: 1379-1387.
13. Åkesson E, Oturai A, Berg J et al. A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis 2002 3: 279-285
14. Broadley S, Sawcer S, D'Alfonso S et al. A genome screen for multiple sclerosis in Italian families. Genes Immun 2001; 2: 205-210.
15. Coraddu F, Sawcer S, D'Alfonso S et al. A genome screen for multiple sclerosis in Sardinian multiplex families. Eur J Hum Genet 2001; 9: 621-662.
16. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
17. Sawcer SJ, Jones HB, Judge D et al. Empirical genomewide significance levels established by whole genome simulations. Genet Epidemiol 1997; 14: 223-229.
18. The Transatlantic Multiple Sclerosis Genetics Cooperative. A meta-analysis of genome screens in multiple sclerosis. Mult Scler 2001; 7: 3-11.
19. Kellar-Wood H, Wood NW, Holmans P et al. Multiple sclerosis and the HLA-D region: linkage and association studies. J Neuroimmunol 1995; 58: 183-190.
20. Stewart GJ, Teutsch SM, Castle M, Heard RN, Bennetts BH. HLA-DR, -DQA1 and -DQB1 associations in Australian multiple sclerosis patients. Eur J Immunogenet 1997; 24: 81-92.
21. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
22. Feakes R, Sawcer S, Smillie B et al. No evidence for the involvement of Interleukin 2 or the immunoglobulin heavy chain cluster in determining susceptibility to multiple sclerosis. J Neurol Neurosurg Psychiat 2000; 68: 679.
23. Broadley SA, Deans J, Sawcer SJ, Clayton D, Compston DA. Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey. Brain 2000; 123: 1102-1111.
24. Becker K, Simon R, Bailey-Wilson J et al. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA 1998; 95: 9979-9984.
25. Jawaheer D, Seldin MF, Amos CI et al. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet 2001; 68: 927-936.
26. Tsao BP, Cantor RM, Kalunian KC et al. Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J Clin Invest 1997; 99: 725-731.
27. Gaffney P, Kearns G, Shark K et al. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA 1998; 95: 14875-14879.
28. Moser K, Neas B, Salmon J et al. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA 1998; 95: 14869-14874.
29. Cho JH, Nicolae DL, Gold LH et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci USA 1998; 95: 7502-7507.
30. Cornelis F, Faure S, Martinez M et al. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA 1998; 95: 10746-10750.
31. Davies JL, Kawaguchi Y, Bennett ST et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
32. Cucca F, Goy JV, Kawaguchi Y et al. A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. Nat Genet 1998; 19: 301-302.
33. Encinas JA, Lees MB, Sobel RA et al. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol 1996; 157: 2186-2192.
34. Encinas JA, Wicker LS, Peterson LB et al. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing IL2. Nat Genet 1999; 21: 158-160.
35. Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13:227-231.
36. Holmans P, Clayton D. Efficiency of typing unaffected relatives in an affected sib-pair linkage study. Am J Hum Genet 1995; 57: 1221-1232.
37. Lahiri DK, Nurnberger Jr JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucl Acids Res 1991; 19: 5444.
38. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 1995; 57: 439-454.
39. Ehm M, Wagner M. A test statistic to detect errors in sib-pair relationships. Am J Hum Genet 1998; 62: 181-188.