Effects of neutral, cationic, and anionic chromium ascorbate complexes on isolated human mitochondrial and genomic DNA

Journal of Biochemistry and Molecular Biology

Volumn 36, Issue 4, 2003, Pages 403-408

  Ay, Ahmet Nedim ^a   Zümreoglu Karan, Birgül ^a   Öner, Reyhan ^a   Ünaleroglu, Canan ^a   Öner, Cihan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Ascorbate; Chromium; DNA cleavage

Indexed keywords

AMINO ACID; ANION; ASCORBIC ACID DERIVATIVE; CATION; CHROMIUM DERIVATIVE; GENOMIC DNA; MITOCHONDRIAL DNA;

AGAR GEL ELECTROPHORESIS; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA CLEAVAGE; DNA DAMAGE; DNA DRUG COMPLEX; DRUG EFFECT; ELECTRICITY; EXPERIMENT; GENE ISOLATION; HUMAN; INCUBATION TIME;

EID: 0042830869     PISSN: 12258687     EISSN: None     Source Type: Journal    
DOI: 10.5483/bmbrep.2003.36.4.403     Document Type: Article

References (45)

1. 3, with nonenzymatic cellular reductants at physiological conditions. Electronic spectra and magnetic studies. Spectr. Lett. 28, 1259-1273.
2. Arakawa, H., Ahmad, R., Naoui, M. and Tajmir-Riahi, H.A. (2000) A comparative study of calf thymus DNA binding to Cr(III) and Cr(VI) ions. Evidence for the guanine N-7-chromium phosphate chelate formation. J. Biol. Chem. 275, 10150-10153.
3. Beyersmann, D. and Köster, A. (1987) On the role of trivalent chromium in chromium genotoxicity. Toxicol. Environ. Chem. 14, 1159-1166.
4. Blasiak, J. and Kowalik, J. (2001) A comparison of the in vitro genotoxicity of tri- and hexa-valent chromium. Mutat. Res. 469, 135-145.
5. Bose, R. N., Fonkeng, B. S., Moghaddas, S. and Stroup, D. (1998) Mechanism of DNA damage by chromium(V) carcinogens. Nucleic Acids. Res. 26, 1588-1596.
6. Capellmann, M. and Bolt, H. M. (1992) Chromium(VI) reducing capacity of ascorbic acid and of human plasma in vitro. Arch. Toxicol. 66, 45-50.
7. Cieslak-Golonka, M. (1995) Toxic and mutagenic effects of chromium(VI). Polyhedron 15, 3667-3689.
8. Codd, R., Dillon, C. T., Levina, A. and Lay, P. A. (2001) Studies on the genotoxicity of chromium: From the test tube to the cell. Coord. Chem. Rev. 216-217, 537-582.
9. Cohen, M. D., Kargacin, B., Klein, C. B. and Costa, M. (1993) Mechanisms of chromium genotoxicity and toxicity. Crit. Rev. Toxicol. 23, 255-281.
10. Connett, P. H. and Wetterhahn, K. E. (1985) In vitro reaction of the carcinogen chromate with cellular thiols and carboxylic acids. J. Am. Chem. Soc. 107, 4282-4288.
11. Fornace, A. J. Jr., Seres, D. S., Lechner, J. F. and Harris, C. C. (1981) DNA-protein cross-linking by chromium salts. Chem-Biol. Interact. 36, 345-354.
12. Goodgame, D. M. L. and Joy, A. M. (1987) EPR study of the Cr(V) and radical species produced in the reduction. Inorg. Chim. Acta 135, 115-118.
13. Hneihen, A. S., Standeven, M. and Wetterhahn, E. K. (1993) Differential binding of chromium(VI) and chromium(III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA. Carcinogenesis 14, 1795-1803.
14. Horning, D. (1975) Distribution of ascorbic acid metabolites and analogues in man and animals. Ann. N. Y. Acad. Sci. 258, 103-117.
15. IARC. (1990) Chromium, Nickel and Welding. Monogr. Eval. Carcinog. Risks. Hum. 49, 257-445.
16. Kaiwar, S. P., Raghavan, M. S. S. and Rao, C. P. (1995) Transition-metal saccharide chemistry and Biology. Synthesis, characterization, redox behaviour, biointeraction and data correlations of dinuclear chromium(III) complexes and their in-vitro interaction with DNA. J. Chem. Soc. Dalton Trans. 1569-1576.
17. Kaiwar, S. P., Sreedhara, A., Raghavan, M. S. S., Rao, C. P., Jadhaw, V. and Ganesh, K. N. (1996) Synthesis, characterization and DNA interaction studies of Cr(III) products isolated from Cr(VI) reduction with SH-containing molecules. Polyhedron 15, 765-774.
18. Kortenkamp, A. and O'Brien, P. (1991) Studies on the binding of chromium(III) complexes to phosphate groups of adenosine-triphosphate. Carcinogenesis 12, 921-926.
19. Kortenkamp, A., Curran, B. and O'Brien, P. (1992) Defining conditions for the efficient in vitro cross-linking of proteins to DNA by chromium(III) compounds. Carcinogenesis 13, 307-308.
20. Lehninger, A. L. (1982) Principles of Biochemistry. Worth Publishers, New York, USA.
21. Levina, A., Barr-David, G., Codd, R., Lay, P. A., Dixon, N. E., Hammershoi, A. and Hendry, P. (1999) In vitro plasmid DNA cleavage by chromium(V) and (IV)-2-hydroxylato complexes. Chem. Res. Toxicol. 12, 371-381.
22. Luo, H., Lu, Y., Mao, Y., Shi, X. and Dalal, S. (1996) Role of chromium(IV) in the chromium(VI)-related free radical formation, dG hydroxylation and DNA damage. J. Inorg. Biochem. 64, 25-35.
23. Mergen, H., Acar, C., Birben, E., Öner, R. and Öner, C. (2000) A safer and relatively shorter method for southern blood hybridization analysis. J. Biochem. Biophys. Methods 44, 73-76.
24. Poncz, M., Solowiejczyk, D., Harpel, B., Mary, Y., Schwartz, E. and Surrey, S. (1982) Construction of human-gene libraries from small amounts of peripheral-blood analysis of beta-like globin genes. Hemoglobin 6, 27-36.
25. Qi, W., Reiter, R. J., Tan, D. -X., Garcia, J. J., Manchester, L. C., Karbownik, M. and Calvo, J. R. (2000) Chromium(III) induced 8-hydroxyguanisine in DNA and its reduction by antioxidants: Comparative effects of melatonin, ascorbate and vitamin E. Environ. Health Perspect. 108, 399-402.
26. Rao, C. P., Kaiwar, S. P. and Raghavan, M. S. S. (1994) Transition-metal saccharide chemistry. Synthesis, spectroscopy, electrochemistry and magnetic studies of chromium hexose complexes and their in-vitro interaction with DNA. Polyhedron 13, 1895-1906.
27. Singh, J. and Snow, E. T. (1998) Chromium(III) decreases the fidelity of human DNA polymerase beta. Biochemistry 37, 9371-9378.
28. Sreedhara, A., Susa, N. and Rao, C. P. (1997) Vanadate and chromate reduction by saccharides and L-ascorbic acid: Effect of the isolated V(IV) and Cr(III) products on DNA nicking, lipid peroxidation, cytotoxicity and on enzymatic and non-enzymatic antioxidants. Inorg. Chim. Acta 263, 189-194.
29. Standeven, A. and Wetterhahn, K. E. (1991) Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, mediates Cr-DNA binding in vitro. Carcinogenesis 12, 1733-1737.
30. Standeven, A. M. and Wetterhahn, K. E. (1992) Ascorbate is the principle reductant of chromium(VI) in rat lung ultrafiltrates and cytosols and mediates chromium-DNA binding in vitro. Carcinogenesis 13, 1319-1324.
31. Stearns, D. M., Kennedy, L. J., Courtney, K. D., Giangrande, P. H., Phieffer, L. S. and Wetterhahn, K. E. (1995) Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro. Biochemistry 34, 910-919.
32. Stearns, D. M. and Wetterhahn, K. E. (1994) Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV) and carbon based radicals. Chem. Res. Toxicol. 7, 219-230.
33. Stearns, D. M. and Wetterhahn, K. E. (1997) Intermediates produced in the reaction of chromium(VI) with dehydroascorbate cause single-strand breaks in plasmid DNA. J. Am. Chem. Soc. 10, 271-278.
34. Sugden, K. D. and Wetterhahn, K. E. (1996) Reaction of chromium(V) with the EPR spin traps 5,5-dimethylpyroline N-oxide and phenyl-N-tert-butyl-nitrone resulting in direct oxidation. J. Am. Chem. Soc. 118, 10811-10818.
35. Sugiyama, M., Tsuzuki, K. and Ogura, R. (1991) Effect of ascorbic acid on DNA damage. Cytotoxicity, glutathione reductase and formation of paramagmetic chromium in Chinese hamster v-75 cells treated with sodium chromate(VI). J. Biol. Chem. 266, 3383-3386.
36. Susa, N., Sreedhara, A. and Rao, C. P. (1997) Vanadate and chromate reduction by saccharides and L-ascorbic acid: Effect of the isolated V(IV) and Cr(III) products on DNA nicking, lipid peroxidation and cytotoxicity. J. Inorg. Biochem. 67, 394-399.
37. Tsou, T C., Lai, H. J. and Yang, J. L. (1999) Effects of mannitol or catalase on the generation of reactive oxygen species leading to DNA damage by chromium(VI) reduction with ascorbate. Chem. Res. Toxicol. 12, 1002-1009.
38. 3+ complexes with DNA. Inorg. Chem. 38, 2683-2687.
39. Wetterhahn, K. E. and Dudek, E. J. (1996) Environmental metal carcinogenesis: Genotoxicity and altered gene expression by direct metal-mediated and indirect oxidative metals. New. J. Chem. 20, 199-203.
40. Zhang, L. and Lay, P. A. (1996) EPR spectroscopic studies of the reactions of chromium(VI) in buffer solutions: Implications for understanding the roles of chromium(V) and chromium(IV) species. J. Am. Chem. Soc. 118, 12624-12637.
41. Zhitkovich, A., Song, Y., Quievryn, G. and Voitkun, V. (2001) Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis. Biochemistry 40, 549-560.
42. Zhitkovich, A., Voitkun, V. and Costa, M. (1996) Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro. Importance of trivalent chromium and phosphate group. Biochemistry 35, 7275-7282.
43. Zümreoglu-Karan, B., to be published.
44. Zümreoglu-Karan, B., Ünaleroolu, C. and Ay, A. N. (2002a) Ascorbic acid as a potential masking agent in the tanning process. Olated Chromium complexes involving ligating ascorbate and bridging sulfate groups. Trans. Met. Chem. 27, 437-441.
45. Zümreoglu-Karan, B., Ay, A. N. and Ünaleroolu, C. (2002b) Monodentate chromium ascorbate complexes prepared via chromate reduction in THF. Syn. React. Inorg. Met. Org. Chem. 32, 1071-1084.