Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats

European Journal of Neuroscience

Volumn 18, Issue 4, 2003, Pages 820-828

  Rebola, Nelson ^a   Coelho, Joana E ^b   Costenla, Ana Rita ^b   Lopes, Luísa V ^b   Parada, António ^c   Oliveira, Catarina R ^a   Soares da Silva, Patrício ^c   De Mendonça, Alexandre ^b   Cunha, Rodrigo A ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c DEPARTMENT OF RESEARCH AND DEVELOPMENT   (Portugal)

Author keywords

A1 receptors; Adenosine; Adenosine release; Ecto nucleotidases; Kindling

Indexed keywords

6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE TRIPHOSPHATE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; N (1 METHYL 2 PHENYLETHYL)ADENOSINE; N(6) CYCLOPENTYLADENOSINE; N(6)-CYCLOPENTYLADENOSINE; N-(1-METHYL-2-PHENYLETHYL)ADENOSINE; NEUROPROTECTIVE AGENT; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; EPILEPTOGENESIS; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; KINDLING; LONG TERM POTENTIATION; MALE; NEUROMODULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SYNAPTIC TRANSMISSION; SYNAPTOSOME; WESTERN BLOTTING; WISTAR RAT;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KINDLING, NEUROLOGIC; LONG-TERM POTENTIATION; MALE; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; SYNAPTIC TRANSMISSION; SYNAPTOSOMES; XANTHINES;

EID: 0042819806     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02815.x     Document Type: Article

References (53)

1. 1 receptor-mediated inhibitory tonus: pre- and postsynaptic components. Neuroscience, 57, 565-575.
2. Anderson, W.W. & Collingridge, G.L. (1997) A data acquisition program for on-line analysis of long-term potentiation and long-term depression. Soc. Neurosci. Abstr., 23, 665.
3. 1 adenosine receptors in different mouse brain areas afer pentylenetetrazol-induced seizures, but not in the epileptic mutant mouse 'tottering'. Brain Res., 534, 251-256.
4. Angelatou, F., Pagonopoulou, O., Maraziotis, T., Olivier, A., Villemeure, J.G., Avoli, M. & Kostopoulos, G. (1993) Upregulation of A1 adenosine receptors in human temporal lobe epilepsy: a quantitative autoradiographic study. Neurosci. Lett., 163, 11-14.
5. Ault, B., Olney, M.A., Joyne, J.L., Boyer, C.E., Notrica, M.A., Soroko, F.E. & Wang, C.M. (1987) Pro-convulsant actions of theophylline and caffeine in the hippocampus: implications for the management of temporal lobe epilepsy. Brain Res., 426, 93-102.
6. Benes, J., Parada, A., Figueiredo, A.A., Alves, P.C., Freitas, A.P., Learmonth, D.A., Cunha, R.A., Garrett, J. & Soares-da-Silva, P. (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J. Med. Chem., 42, 2582-2587.
7. Berman, R.F., Fredholm, B.B., Aden, U. & O'Connor, W.T. (2000) Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. Brain Res., 872, 44-53.
8. Bonan, C.D., Amaral, O.B., Rockenbach, I.C., Walz, R., Battastini, A.M., Izquierdo, I. & Sarkis, J.J. (2000a) Altered ATP hydrolysis induced by pentylenetetrazol kindling in rat brain synaptosomes. Neurochem. Res., 25, 775-779.
9. Bonan, C.D., Walz, R., Pereira, G.S., Worm, P.V., Battastini, A.M., Cavalheiro, E.A., Izquierdo, I. & Sarkis, J.J. (2000b) Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy. Epilepsy Res., 39, 229-238.
10. Brodie, M.S., Lee, K.S., Fredholm, B.B., Stahle, L. & Dunwiddie, T.V. (1987) Central versus peripheral mediation of responses to adenosine receptor agonists: evidence against a central mode of action. Brain Res., 415, 323-330.
11. Costenla, A.R., de Mendonça, A. & Ribeiro, J.A. (1999) Adenosine modulates synaptic plasticity in hippocampal slices from aged rats. Brain Res., 851, 228-234.
12. Cunha, R.A. (2001) Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem. Int., 38, 107-125.
13. Cunha, R.A., Almeida, T. & Ribeiro, J.A. (2000) Modification by arachidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus. J. Biol. Chem., 275, 37 572-37 581.
14. Cunha, R.A., Almeida, T. & Ribeiro, J.A. (2001b) Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. J. Neurochem., 76, 372-382.
15. 1 receptor binding sites in the rat brain: effect of cis-unsaturated free fatty acids. Eur. J. Biochem., 268, 2939-2947.
16. 1 receptors. J. Neurosci., 18, 1987-1995.
17. Cunha, R.A., Vizi, E.S., Ribeiro, J.A. & Sebastião, A.M. (1996) Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J. Neurochem., 67, 2180-2187.
18. Daval, J.L. & Sarfati, A. (1987) Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain. Life Sci., 41, 1685-1693.
19. 1 receptors and their coupling to G proteins following seizures in the developing rat. Dev. Brain Res., 59, 237-247.
20. Dragunow, M. (1988) Purinergic mechanisms in epilepsy. Prog. Neurobiol., 31, 85-108.
21. Dragunow, M. & Robertson, H.A. (1987) 8-Cyclopentyl-1,3-dimethylxanthine prolongs epileptic seizures in rats. Brain Res., 417, 377-379.
22. Dunwiddie, T.V. (1980) Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia, 21, 541-548.
23. Dunwiddie, T.V. (1999) Adenosine and suppression of seizures. In Delgado-Escueta, A.V., Wilson, W.A., Olsen, R.W. & Porter, R.J. (Eds), Jasper's Basic Mechanisms of the Epilepsies, 3rd edn. Advances in Neurology, Vol. 79. Lippincott, Williams & Wilkins, Philadelphia, pp. 1001-1010.
24. Dunwiddie, T.V. & Masino, S.A. (2001) The role and regulation of adenosine in the central nervous system. Ann. Rev. Neurosci, 24, 31-55.
25. During, M.J. & Spencer, D.D. (1992) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann. Neurol., 32, 618-624.
26. 1 adenosine receptors in nucleus reticularis thalami in rats with genetic absence epilepsy. Neuroreport, 9, 2135-2140.
27. Ekonomou, A., Sperk, G., Kostopoulos, G. & Angelatou, F. (2000) Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-reduced limbic seizures. Neurosci. Lett., 284, 49-52.
28. Eldridge, F.L., Paydarfar, D., Scott, S.C. & Dowell, R.T. (1989) Role of endogenous adenosine in recurrent generalized seizures. Exp. Neurol., 103, 179-185.
29. Glass, M., Faull, R.L.M., Bullock, J.Y., Jansen, K., Mee, E.W., Walker, E.B., Synek, B.J.L. & Dragunow, M. (1996) Loss of A1 adenosine receptors in human temporal lobe epilepsy. Brain Res., 710, 56-68.
30. Gleiter, C.H., Deckert, J., Nutt, D.J. & Marangos, P.J. (1989) Electroconvulsive shock (ECS) and the adenosine neuromodulatory system: effect of single and repeated ECS on the adenosine A1 and A2 receptors, adenylate cyclase, and the adenosine uptake site. J. Neurochem., 52, 641-646.
31. Huber, A., Padrum, V., Déglon, N., Aebischer, P., Mölher, H. & Boison, D. (2001) Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc. Natl Acad. Sci. USA, 98, 7611-7616.
32. 1 receptor. Proc. Natl Acad. Sci. USA, 98, 9407-9412.
33. Kulkarni, S.K. & George, B. (1994) Kindling model of epilepsy. Meth. Find. Exp. Clin. Pharmacol., 16, 735-745.
34. Latini, S. & Pedata, F. (2001) Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J. Neurochem., 79, 463-484.
35. Lewin, E. & Bleck, V. (1981) Electroshock seizures in mice: effect on brain adenosine and its metabolites. Epilepsia, 22, 577-581.
36. Malhotra, J. & Gupta, Y.K. (1997) Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. Br. J. Pharmacol., 120, 282-288.
37. de Mendonça, A., Sebastião, A.M. & Ribeiro, J.A. (2000) Adenosine: does it have a neuroprotective role after all? Brain Res. Rev., 33, 258-274.
38. Nagy, A.K., Houser, C.R. & Delgado-Escueta, A.V. (1990) Synaptosomal ATPase activities in temporal cortex and hippocampal formation of humans with focal epilepsy. Brain Res., 529, 192-201.
39. Ochiisshi, T., Takita, M., Ikemoto, M., Nakata, H. & Suzuki, S.S. (1999) Immunohistochemical analysis on the role of adenosine A1 receptors in epilepsy. Neuroreport, 10, 3535-3541.
40. 3H]nitrobenzylthioinosine adenosine uptake binding in the mouse brain after acute pentylenetetrazol-induced seizures. J. Neurosci. Res., 53, 433-442.
41. Paxinos, G. & Watson, C. (1997) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
42. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol., 32, 281-294.
43. 2A receptors to facilitate acetylcholine release in the rat hippocampus. Eur. J. Pharmacol., 454, 31-38.
44. Schoen, S.W., Ebert, U. & Loscher, W. (1999) 5′-Nucleotidase activity in mossy fibers in the dentate gyms of normal and epileptic rats. Neuroscience, 93, 519-526.
45. Sebastião, A.M., Cunha, R.A., de Mendonça, A. & Ribeiro, J.A. (2000) Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats. Br. J. Pharmacol., 131, 1629-1634.
46. 1 receptors in the rat brain in the kindling model of epilepsy. Eur. J. Pharmacol., 265, 121-124.
47. Suzuki, Y., Wang, L., Edge, J., Mimaki, T. & Walson, P.D. (1994) Anticonvulsant tolerance to clonazepam in amygdala kindled rats: clonazepam concentrations and benzodiazepine receptor binding. Neuropharmacology, 33, 869-874.
48. 1 receptors within rat hippocampus. Neurochem. Res., 26, 225-230.
49. Whitcomb, K., Lupica, C.R., Rosen, J.B. & Berman, R.F. (1990) Adenosine involvement in postictal events in amygdala-kindled rats. Epilepsy Res., 6, 171-179.
50. Wiesner, J.B., Ugarkar, B.G., Castellino, A.J., Barankiewicz, J., Dumas, D.P., Gruber, H.E., Foster, A.C. & Erion, M.D. (1999) Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy. J. Pharmacol. Exp. Ther., 289, 1669-1677.
51. Winn, H.R., Welsh, J.E., Bryner, C., Rubio, R. & Berne, R.N. (1979) Brain adenosine production during the initial 60 seconds of bicuculline seizures in rats. Acta Physiol. Scand., 72, 536-537.
52. Young, D. & Dragunow, M. (1994) Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms. Neuroscience, 58, 245-261.
53. Zhang, G., Franklin, P.H. & Murray, T.F. (1993) Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. J. Pharmacol. Exp. Ther., 264, 1415-1424.