A concise building block approach to a diverse multi-arrayed library of the circumdatin family of natural products

Synthesis

Volumn , Issue 11, 2003, Pages 1707-1711

  Grieder, Alfred ^a   Thomas, Andrew W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

aza Wittig reaction; Natural product libraries; Polymer supported triphenylphosphine; Privileged scaffolds

Indexed keywords

CARBOXYLIC ACIDS; PURIFICATION;

ANTHRANILIC ACIDS;

AROMATIC COMPOUNDS;

ALKALOID; ANTHRANILIC ACID; ASPERLICIN; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; BENZOMALVIN; NATURAL PRODUCT; PHOSPHINE; POLYMER; QUINAZOLINONE DERIVATIVE; SCLEROTIGENIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS; WITTIG REACTION;

EID: 0042739212     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-40870     Document Type: Article

References (13)

1. Dai, J.-R.; Carte, B. K.; Sidebottom, P. J.; Yew, A. L. S.; Ng, S.-W.; Huang, Y.; Butler, M. S. J. Nat. Prod. 2001, 64, 125.
2. Raebaek, L.; Breinholt, J. J. Nat. Prod. 1999, 62, 904.
3. Raebaek, L.; Breinholt, J.; Frisvald, J. C.; Christopherson, C. J. Org. Chem. 1999, 64, 1689.
4. Sun, H. H.; Barrow, C. J.; Sedlock, D. M.; Gillum, A. M.; Cooper, R. J. Antibiotics 1994, 47, 515.
5. (a) Sugimori, T.; Okawa, T.; Eguchi, S.; Yashima, E.; Kakehi, A.; Okamoto, Y. Tetrahedron 1998, 54, 7997.
6. (b) Sugimori, T.; Okawa, T.; Eguchi, S.; Yashima, E.; Okamoto, Y. Chem. Lett. 1997, 869.
7. He, F.; Foxman, B. M.; Snider, B. B. J. Am. Chem. Soc. 1998, 120, 6417.
8. (a) Joshi, B. K.; Gloer, J. B.; Wicklow, D. T.; Dowd, P. F. J. Nat. Prod. 1999, 62, 650.
9. (b) Total synthesis of Circumdatin F and Sclerotigenin: Snider, B. B.; Busuyek, M. N. Tetrahedron 2001, 57, 3301.
10. Herpin, T. F.; Van Kirk, K. G.; Salvino, J. M.; Yu, S. T.; Labaudiniere, R. F. J. Comb. Chem. 2000, 2, 513.
11. Thomas, A. W. Bioorg. Med. Chem. Lett. 2002, 12, 1881.
12. Masciadri, R.; Thomas, A. W.; Wichmann, J. PCT WO 200240487, 2002.
13. For a more detailed discussion of workflow procedures and automation technology utilized for synthetic arrays, see: Nettekoven, M.; Thomas, A. W. Curr. Med. Chem. 2002, 9, 2179.