Effect of sildenafil citrate on an orthotopic prostate cancer growth and metastasis model

Journal of Urology

Volumn 170, Issue 3, 2003, Pages 994-997

  Qian, Chao Nan ^a,c   Takahashi, Masayuki ^a,d   Kahnoski, Richard J ^b   Teh, Bin Tean ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b SPECTRUM HEALTH   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Mice, nude; Neoplasm metastasis; Prostate; Prostatic neoplasms

Indexed keywords

CYCLIC GMP; SILDENAFIL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CELL STRAIN; CELL STRAIN PC 3; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; HUMAN; HUMAN CELL; LOW DRUG DOSE; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; SIDE EFFECT; TUMOR GROWTH;

EID: 0042737762     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000080321.99119.df     Document Type: Article

References (20)

1. Boyce, E. G. and Umland, E. M.: Sildenafil citrate: a therapeutic update. Clin Ther, 23: 2, 2001
2. Glossmann, H., Petrischor, G. and Bartsch, G.: Molecular mechanisms of the effects of sildenafil (VIAGRA). Exp Gerontol, 34: 305, 1999
3. Vale, J.: Erectile dysfunction following radical therapy for prostate cancer. Radiother Oncol, 57: 301, 2000
4. Katz, S. D., Balidemaj, K., Homma, S., Wu, H., Wang, J. and Maybaum, S.: Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol, 36: 845, 2000
5. Traverse, J. H., Chen, Y. J., Du, R. and Bache, R. J.: Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise. Circulation, 102: 2997, 2000
6. Ichinose, F., Erana-Garcia, J., Hromi, J., Raveh, Y., Jones, R., Krim, L. et al: Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med, 29: 1000, 2001
7. Pache, M., Meyer, P., Prunte, C., Orgul, S., Nuttli, I. and Flammer, J.: Sildenafil induces retinal vasodilatation in healthy subjects. Br J Ophthalmol, 86: 156, 2002
8. Paris, G., Sponsel, W. E., Sandoval, S. S., Elliott, W. R., Trigo, Y., Sanford, D. K. et al: Sildenafil increases ocular perfusion. Int Ophthalmol, 23: 355, 2001
9. Incrocci, L., Slob, A. K. and Levendag, P. C.: Sexual (dys)function after radiotherapy for prostate cancer: a review. Int J Radiat Oncol Biol Phys, 52: 681, 2002
10. Zelefsky, M. J., McKee, A. B., Lee, H. and Leibel, S. A.: Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. Urology, 53: 775, 1999
11. Kedia, S., Zippe, C. D., Agarwal, A., Nelson, D. R. and Lakin, M. M.: Treatment of erectile dysfunction with sildenafil citrate (Viagra) after radiation therapy for prostate cancer. Urology, 54: 308, 1999
12. Merrick, G. S., Butler, W. M., Lief, J. H., Stipetich, R. L., Abel, L. J. and Dorsey, A. T.: Efficacy of sildenafil citrate in prostate brachytherapy patients with erectile dysfunction. Urology, 53: 1112, 1999
13. Weber, D. C., Bieri, S., Kurtz, J. M. and Miralbell, R.: Prospective pilot study of sildenafil for treatment of postradiotherapy erectile dysfunction in patients with prostate cancer. J Clin Oncol, 17: 3444, 1999
14. Incrocci, L., Koper, P. C., Hop, W. C. and Slob, A. K.: Sildenafil citrate (Viagra) and erectile dysfunction following external beam radiotherapy for prostate cancer: a randomized, double-blind, placebo-controlled, cross-over study. Int J Radiat Oncol Biol Phys, 51: 1190, 2001
15. Baniel, J., Israilov, S., Segenreich, E. and Livne, P. M.: Comparative evaluation of treatments for erectile dysfunction in patients with prostate cancer after radical retropubic prostatectomy. BJU Int, 88: 58, 2001
16. Lala, P. K. and Chakraborty, C.: Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol, 2: 149, 2001
17. Gallo, O., Masini, E., Morbidelli, L., Franchi, A., Fini-Storchi, I., Vergari, W. A. et al: Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst, 90: 587, 1998
18. Kong, L., Dunn, G. D., Keefer, L. K. and Korthuis, R. J.: Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin Exp Metastasis, 14: 335, 1996
19. Rembrink, K., Romijn, J. C., van der Kwast, T. H., Rubben, H. and Schroder, F. H.: Orthotopic implantation of human prostate cancer cell lines: a clinically relevant animal model for metastatic prostate cancer. Prostate, 31: 168, 1997
20. Walker, D. K., Ackland, M. J., James, G. C., Muirhead, G. J., Rance, D. J., Wastall, P. et al: Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica, 29: 297, 1999